基本情報
- CAS
71395-14-7- 標準SMILES
Cc1cccc(C)c1NC(=O)C(C)N.Cl- InChIKey
AMZACPWEJDQXGW-UHFFFAOYSA-N- 分子式
- C11H17ClN2O
- 平均分子量
- 228.72 g/mol
- 単同位体質量
- 228.1029409
概要
Tocainide Hydrochloride is the hydrochloride salt form of tocainide, a primary amine analog of lidocaine exhibiting class 1b antiarrhythmic property. Tocainide hydrochloride stabilizes the neuronal membrane by reversibly binding to and blocking open and inactivated voltage-gated sodium channels. This inhibits the inward sodium current required for the initiation and conduction of impulses and reduces the excitability of myocardial cells. This agent reduces the rate of rise and amplitude, and shortens the action-potential duration (APD) in both the Purkinje and muscle fibers. Tocainide also shortens the effective refractory period (ERP) of Purkinje fibers resulting in an increased the ERP/APD ratio. Overall these effects lead to the slowing of nerve impulses and stabilization of the heartbeat.
名称と識別子
- 優先名称
- Tocainide Hydrochloride
- IUPAC
- 2-amino-N-(2,6-dimethylphenyl)propanamide;hydrochloride
- 現地名
- rac-(R*)-2-アミノ-N-(2,6-ジメチルフェニル)プロパンアミド·塩酸塩
- 英語名
- TOCAINIDE
- 分子式
- C11H16N2O
- 分子量
- 192.26
名称と別名
Tocainide hydrochloride71395-14-7Tocainide HClTonocardTaquidilXylotocanTocainide MonohydrochlorideDTXSID50455402K7I38CKN5Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, monohydrochlorideDTXCID3025540Hydrochloride, Tocainide
名称をさらに表示
rac-(R*)-2-アミノ-N-(2,6-ジメチルフェニル)プロパンアミド·塩酸塩TOCAINIDE 塩酸塩rac-(R*)-2-アミノ-N-(2,6-ジメチルフェニル)プロパンアミド・塩酸塩Einecs 275-361-2(±)-Form hydrochlorideTocainide HCl - Bio-X ?Tocainide (+-)-form hydrochloride2-Amino-2',6'-propionoxylidide hydrochloride(1)-2-Amino-N-(2,6-dimethylphenyl)propionamide hydrochloride(±)-2-amino-N-(2,6-dimethylphenyl)propionamide hydrochloridePropanamide,2-amino-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)rac-(R*)-2-Amino-N-(2,6-dimethylphenyl)propanamide·hydrochloride
RefChem:56137275-361-2NSC130820NSC169863NSC6210335891-93-1Tocainide.HClTocainide (hydrochloride)
物性
構造計算による物性
- 極性表面積
- 55.1 Ų
- 水素結合供与体数
- 3
- 水素結合受容体数
- 2
- 回転可能結合数
- 2
- 重原子数
- 15
- 形式電荷
- 0
- 複雑度
- 195
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
- 融点
- 246 · 246-247°
- 貯蔵温度
- 2 · 2-8°C
- 溶解性
- 20 mg/mL · DMSO：>20mg/mL
- 外見
- 個体
- 色
- 白い
- InChI
- 1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H
- InChIKey
- AMZACPWEJDQXGW-UHFFFAOYSA-N
- SMILES
- Cl[H].CC(N)C(=O)Nc1c(C)cccc1C
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 1 notifications to the ECHA C&L Inventory.
危険有害性情報
Hazard Classes and CategoriesAcute Tox. 4 (100%)
安全データ
- wgk
- 3
- ridadr
- UN1230 - class 3 - PG 2 - Methanol, solution
- risk_code
- 22
- hazard_code
- Xn
- Hazard Classifications
- Acute Tox. 4 Oral
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.
応用分野
使用Tocainide Hydrochloride is used as an anti-arrythmic drug as myocardial depressants.
サプライヤー18 社
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
Aladdin Scientific[email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
湖北扬信医药科技有限公司0714-3999001 19171453112 · [email protected]
上海陶素生化科技有限公司021-33632979 · [email protected]
上海喀露蓝科技有限公司18149758185 18149758185 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
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