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化工社化工社 化学情報印刷レポート · 研究参考用
HCID 11040作成日：2026年10月27日

乳酸メチル

乳酸メチル · 2-ヒドロキシプロピオン酸メチル · 2-ヒドロキシプロパン酸メチル · メチル 2-ヒドロキシプロパノアート · Methyl 2-hydroxypropanoate · LACTIC ACID METHYL ESTER · Propanoicacid,2-hydroxy-,methylester · METHYL LACTATE

https://huagongshe.com/ja/chemical/11040

乳酸メチル の分子構造式

識別子と物理属性

CAS No.2155-30-8
分子式C4H8O3
平均分子量104.1 g/mol
単同位体質量104.04734412 g/mol
SMILESCOC(=O)C(C)O
InChIKeyLPEKGGXMPWTOCB-UHFFFAOYSA-N
PubChem CID11040
ChEMBLCHEMBL3183351
ChEBICHEBI:83221
EC No.208-930-0
DTXSIDDTXSID0027197
現地名乳酸メチル

化学・物理的性質

XLogP-0.1
極性表面積46.5
水素結合供与体数1
水素結合受容体数3
回転可能結合数2
重原子数7
形式電荷0
複雑度69.3
SolventsSolvents -> Esters (<C12)
化粧品Cosmetic ingredients (Methyl Lactate) -> CIR (Cosmetic Ingredient Review)
密度1.09 at 19 °C/Bulk density/ (wt/gal)= 9 LB @ 68 °F1.093 g/mL at 20 °C(lit.)
Viscosity2.94 cP at 20 °C
Color/FormColorless, transparent liquid
溶解度Miscible in water with decompositionSoluble in alcohol, etherMiscible with most organic solvents混和性、加水分解
引火点51 °C (124 °F) - closed cup121 °F (49 °C) (closed cup)
沸点144-145 °C35 °C (6 mmHg)
DecompositionWhen heated to decomposition it emits acrid smoke and irritating vapors.
融点Freezing Point: approximately -66 °C-66°C
蒸気密度3.6 (Air = 1)
蒸気圧1.85 [mmHg]3.5 mm Hg at 25 °C
比旋光度[α]D20+1.410～+1.418
屈折率n20/D 1.413
貯蔵条件Flammables area
外観・状態液体
pKa（酸解離定数）13.07±0.20(Predicted)
色無色透明～淡黄色
比重1.09
Merck14,6094
BRN1720586
ヘンリー定数9.1×100 mol/(m3Pa) at 25℃, Sanz and Gmehling (2005)
化粧品成分の機能溶媒香料香料
InChI1S/C4H8O3/c1-3(5)4(6)7-2/h3,5H,1-2H3
InChIKeyLPEKGGXMPWTOCB-UHFFFAOYSA-N
SMILESCOC(=O)C(C)O
LogP（分配係数）-0.670 (est)
CAS データベース547-64-8(CAS DataBase Reference)
NISTの化学物質情報Propanoic acid, 2-hydroxy-, methyl ester(547-64-8)
EPAの化学物質情報Methyl lactate (547-64-8)

化学的特性

Methyl lactate is a colorless transparent liquid. It is soluble/miscible in water, acetone, ethyl alcohol, and other organic solvents. It is used as a cellulose acetate solvent.

安全性と法規制

GHS 分類WarningH226: Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
規制情報Methyl lactate: Does not have an individual approval but may be used under an appropriate group standard
火災の可能性Moderate fire risk.
有害性の概要Decomposed by water[Hawley] Mildly irritating[HSDB] An eye and respiratory tract irritant[eChemPortal: ESIS]See ORGANIC SOLVENTS.
Flammable LimitsLower flammable limit: : 2.2% by vol @ 212 °F (100 °C)
NFPA Hazard Classification1 - Materials that, under emergency conditions, can cause significant irritation.2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.0 - Materials that in themselves are normally stable, even under fire conditions.
Toxic Combustion ProductsSpecial hazards arising from the substance or mixture: Carbon oxides
Hazard Classes and CategoriesFlam. Liq. 3 (100%)Flammable liquid - category 3Flammable liquids - Category 3
Skin, Eye, and Respiratory IrritationsMethyl Lactate was not irritating to guinea pig eyes./Methyl lactate/ dropped into the eyes of rabbits ... was classified as non-irritating.
Hazardous Reactivities and IncompatibilitiesIncompatible materials: Oxidizing agents, acids, Bases
Firefighting Hazards

用途

用途

セルロースアセテート溶剤、ラッカー,印刷インキなどの配合剤,医薬や農薬の合成原料

説明

Methyl lactate is a compound with many uses. It can be used as a solvent, as a starting material for the manufacture of polyiactic acid, or as a starting material for numerous other reactions. For example, it can be used as intermediate in lactic acid purification, and as building block in the synthesis of chiral components, e.g., pesticides, and as a starting material for lactide manufacture.

使用

Methyl lactate is used as a solvent for nitrocellulose, cellulase acetate, cellulase acetobutyrote and cellulase acetaprapionate. It is used in the manufacture of lacquers and dopes where it contributes high tolerance for diluents, good flaw and blush resistance.

製法・合成法

純化方法

Methyl lactate is easily hydrolyzed and often contains impurities such as free lactic acid, methanol and water. Free acid can be removed by washing after neutralization with alkali. Moisture can be removed by azeotropic distillation of an azeotropic mixture with benzene. Then, it was purified by distillation under reduced pressure. Since calcium chloride and the like form molecular compounds with methyl lactate, they cannot be used as desiccants. When the methyl lactate is mixed with water, it can be extracted and recovered with benzene, ether, etc.

Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. ... Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
消火手順Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.Use water spray to cool unopened containers.For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT get water inside containers. Do NOT use straight streams of water.
保管条件Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Moisture sensitive.
清掃方法ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areasEnvironmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drainsMethods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.
処分方法SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this materialContaminated packaging: Dispose of as unused product.
Preventive MeasuresPrecautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Personal Protective Equipment (PPE)Eye/face protection: Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).Skin protection: Handle with gloves.Body Protection: Impervious clothing. Flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
生態毒性値EC50Species: Daphnia magna (Water flea)Conditions: freshwater, staticConcentration: 780000 ug/L for 48 hr (95% confidence interval: 689000-882000 ug/L)Effect: intoxication, decreased mobility /97% purity/
環境中動態TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that methyl lactate is expected to have very high mobility in soil(SRC). Volatilization of methyl lactate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.8X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 3.5 mm Hg(3), and an assigned value for water solubility of 1.0X10+6 mg/L (miscible)(4). Methyl lactate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). A 76% of theoretical BOD using activated sludge in a 28-day OECD 301D closed-bottle test indicates methyl lactate is readily biodegradable(5) and suggests that biodegradation is an important environmental fate process in soil(SRC). The lactate ester group of compounds are generally considered to be readily biodegradable(5,6). Hydrolysis may be an important fate process in moist alkaline soils(SRC). A base-catalyzed second-order hydrolysis rate constant of 1.18 L/mole-sec(SRC) was estimated using a structure estimation method for 25 °C(2)this corresponds to half-lives of 68, 6.8 and 0.68 days at pH values of 7, 8 and 9, respectively(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that methyl lactate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 4.8X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 3.5 mm Hg(4), and an assigned value for water solubility of 1.0X10+6 mg/L (miscible)(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from an estimated log Kow of -0.67(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 76% of theoretical BOD using activated sludge in a 28-day OECD 301D closed-bottle test indicates methyl lactate acid is readily biodegradable(7) and suggests that biodegradation is an important environmental fate process in water(SRC). The lactate ester group of compounds are generally considered to be readily biodegradable(7,8). Hydrolysis may be an important fate process in alkaline waters(SRC). A base-catalyzed second-order hydrolysis rate constant of 1.18 L/mole-sec(SRC) was estimated using a structure estimation method for 25 °C(2)ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyl lactate, which has a vapor pressure of 3.5 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methyl lactate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 6 days(SRC), calculated from its rate constant of 2.8X10-12 cu cm/molecule-sec at 25 °C(3). Methyl lactate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).
有害作用Neurotoxin - Acute solvent syndrome
毒性の概要Based on the available information included in this report, the CIR Expert Panel concludes that Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations less than or equal to 10%, at final formulation pH greater than or equal to 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations less than or equal to 30%, at final formulation pH greater than or equal to 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection...Methyl Lactate...Safe for use in cosmetics, with qualificationsIDENTIFICATION AND USE: Methyl lactate is a colorless, transparent liquid. It is used as a solvent. HUMAN EXPOSURE AND TOXICITY: There is no data. ANIMAL STUDIES: Methyl Lactate was not irritating to guinea pig and rabbit eyes. The estimated average lethal dose for the female rat following ip injection of laboratory grade methyl lactate was >2000 mg/kg. Observations included narcosis, respiratory distress, and peritoneal adhesions. Hydrolysis of lactate esters to lactic acid and alcohol has been reported to occur after both skin application and oral administration. Lactic acid is a naturally occurring metabolite, and its toxicity is mostly a result of its acidity.
Ongoing Test StatusEPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPAICSS Dashboard ApplicationAvailable from, as of December 17, 2015: http://actor.epa.gov/dashboard/]
Soil Adsorption/MobilityUsing a structure estimation method based on molecular connectivity indices(1), the Koc of methyl lactate can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that methyl lactate is expected to have very high mobility in soil.
Artificial Pollution SourcesMethyl lactate's production and use as a solvent for cellulose acetate, nitrocellulose, cellulose acetobutyrate, cellulose acetopropionate, lacquers and stains(1) as well as an ingredient in some cosmetics(2) and development as a possible "green" solvent(3) may result in its release to the environment through various waste streams(SRC).
Environmental BiodegradationAEROBIC: Methyl lactate, present at 2.04 mg/L, reached 76% of its theoretical BOD in 28 days using an activated sludge inoculum in the OECD 301D Method (Closed Bottle Test) which classified the compound as readily biodegradable(1). The similar compound ethyl lactate was found to be readily biodegradable using the Japanese MITI test(2). The lactate ester group of compounds are generally considered to be readily biodegradable(1,3).
Environmental BioconcentrationAn estimated BCF of 3 was calculated in fish for methyl lactate(SRC), using an estimated log Kow of -0.67(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Volatilization from Water/SoilThe Henry's Law constant for methyl lactate is estimated as 4.8X10-7 atm-cu m/mole(SRC) derived from its vapor pressure, 3.5 mm Hg(1), and an assigned value for water solubility of 1.00X10+6 mg/L (miscible)(2). This Henry's Law constant indicates that methyl lactate is expected to be essentially nonvolatile from water surfaces(3). Methyl lactate's estimated Henry's Law constant indicates that volatilization from moist soil surfaces is not expected to occur(SRC). Methyl lactate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).
Non-Human Toxicity Excerpts/LABORATORY ANIMALS: Acute Exposure/ Methyl Lactate was not irritating to guinea pig eyes./LABORATORY ANIMALS: Acute Exposure/ Methyl Lactate. The estimated average lethal dose for the female rat (either albino, Wistar, or Glaxo-Wistar) following IP injection of laboratory grade Methyl Lactate was >2000 mg/kg. Observations included /CNS depression/, respiratory distress, and peritoneal adhesions. The estimated maximum nontoxic dose and estimated maximum dose without gross lesions at necropsy was 500 mg/kg./LABORATORY ANIMALS: Acute Exposure/ Lactate esters dropped into the eyes of rabbits caused eye irritation. Tested esters that yielded a positive response were ethyl, n-propyl, n-butyl, lauryl, and myristyl lactate. Methyl lactate, however, was classified as non-irritating.
Environmental Abiotic DegradationThe rate constant for the vapor-phase reaction of methyl lactate with photochemically-produced hydroxyl radicals has been measured as 2.8X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 6 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). Methyl lactate is reported to be miscible in water with decomposition(3). A base-catalyzed second-order hydrolysis rate constant of 1.18 L/mole-sec(SRC) was estimated using a structure estimation method for 25 °C(2)this corresponds to half-lives of 68 and 6.8 days at pH values of 7 and 8, respectively(2). Methyl lactate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).
F21
水環境危害等級（WGK）1
TSCA 収載状態TSCA listed
RTECS 番号OD5670000
輸送番号（UN）UN 3272 3/PG 3
税関コード29181100
危険文句（R）10-36/37
化審法(2)-1370
消防法危-4-2-III
危険表示Xi
安全措置（S）24-24/25
危険等級3.2Eye Irrit. 2Flam. Liq. 3STOT SE 3
包装等級III
貯蔵分類3 - Flammable liquids
有害物質データ547-64-8(Hazardous Substances Data)