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HCID 11089作成日：2026年10月27日

トリメリット酸無水物

トリメリット酸無水物 · 1,2,5-ベンゼントリカルボン酸1,2-無水物 · 4-カルボキシフタル酸1,2-無水物 · 4-カルボキシフタル酸1,2-アンヒドリド · トリメリト酸無水物 · 1,3-ジヒドロ-1,3-ジオキソイソベンゾフラン-5-カルボン酸 · 1,3-ジオキソイソベンゾフラン-5-カルボン酸 · 1,2,4-ベンゼントリカルボン酸1,2-無水物

https://huagongshe.com/ja/chemical/11089

トリメリット酸無水物 の分子構造式

識別子と物理属性

CAS No.552-30-7
分子式C9H4O5
平均分子量192.12 g/mol
単同位体質量192.00587323 g/mol
SMILESO=C(O)c1ccc2c(c1)C(=O)OC2=O
InChIKeySRPWOOOHEPICQU-UHFFFAOYSA-N
PubChem CID11089
ChEMBLCHEMBL2137687
ChEBICHEBI:53050
EC No.209-008-0
DTXSIDDTXSID7026235
現地名トリメリット酸無水物

化学・物理的性質

XLogP0.8
極性表面積80.7
水素結合供与体数1
水素結合受容体数5
回転可能結合数1
重原子数14
形式電荷0
複雑度308
PolymersPlastics & Rubber -> Acid Anhydrides, Cyclic
SpringerMaterials PropertiesBoiling point
密度1.55 at 68 °F (NTP, 1992) - Denser than waterwill sink1.54
Color/FormCrystalsColorless solid
溶解度less than 1 mg/mL at 68 °F (NTP, 1992)Sol at 25 °C: 0.002 g/100 g carbon tetrachloride0.06 g/100 g ligroin0.4 g/100 g mixed xylenes15.5 g/100 g dimethyl formamide49.6 g/100 g acetone21.6 g/100 g ethyl acetate36.5 g/100 g 2-butanone at 25 °C38.4 g/100 g cyclohexanone at 25 °C0.06 g/100 g mineral spirits at 25 °CSolubility in water: reaction24.4g/l（分解）分解する
引火点440.6 °F (NTP, 1992)227 °C o.c.
沸点464 to 473 °F at 14 mmHg (NTP, 1992)390 °CBoiling point: 240-245 °C at 14 mm HgBoiling point 240-245 °C at 14 mm Hgat 1.87kPa: 240-245 °C464-473 °F at 14 mmHg
DecompositionWhen heated to decomposition it emits acrid smoke and irritating fumes.
融点329 to 336 °F (NTP, 1992)161-163.5 °C329-336 °F322 °F163-166 °C (lit.)
蒸気密度6.6 (NTP, 1992) - Heavier than airwill sink (Relative to Air)Relative vapor density = 6.6 (air =1)Relative vapor density (air = 1): 6.66.6 (vs air)
蒸気圧4e-06 mmHg at 77 °F (NTP, 1992)0.00000986 [mmHg]Vapor pressure: 4X10-6 mm HgVapor pressure of liquid trimellitic anhydride = 2.25 mm Hg at 200 °CVapor pressure at 25 °C: negligible0.000004 mmHg<0.01 mm Hg ( 20 °C)
Food Contact SubstancesFCS -> FDA Cumulative Estimated Daily Intake (CEDI)FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFRFCS -> FDA Inventory of Effective Food Contact Substance (FCS) Notifications
屈折率1.4717 (estimate)
貯蔵条件Store below +30°C.
pKa（酸解離定数）3.11±0.20(Predicted)
外観・状態フレーク
色ホワイトからオフホワイト
pH2 (21g/l, H2O, 20℃)
爆発限界1-7%(V)
Merck14,9703
BRN9394
安定性安定。湿気に敏感。
InChI1S/C9H4O5/c10-7(11)4-1-2-5-6(3-4)9(13)14-8(5)12/h1-3H,(H,10,11)
InChIKeySRPWOOOHEPICQU-UHFFFAOYSA-N
SMILESOC(=O)c1ccc2C(=O)OC(=O)c2c1
LogP（分配係数）0.06-0.54 at 20℃
CAS データベース552-30-7(CAS DataBase Reference)
NISTの化学物質情報Trimellitic anhydride(552-30-7)
EPAの化学物質情報Trimellitic anhydride (552-30-7)

化学的特性

Trimellitic anhydride is a white powder or flakes. It is the anhydride of trimellitic acid (1,2,4-benzenetricarboxylic acid). It is soluble in water, ethanol, acetone and other general organic solvents.

化学性质

有機酸のなかで耐熱性，耐薬品性が優れており，樹脂原料として工業的に重要である。

安全性と法規制

GHS 分類DangerH317: May cause an allergic skin reaction [Warning Sensitization, Skin]P233, P260, P261, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P333+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1477) of reports.H317 (99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]
規制情報Chemical: 5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo-Hazard Traits - Respiratory ToxicityCouncil Directive (EEC) No 109/1989 (Repealed by Reg. EC No 1935/2004 (amended))5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 05-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15095Substance: Benzene-1,2,4-tricarboxylic acid 1,2 anhydride
その他の安全情報IMAP assessments - 5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo-: Environment tier I assessment
火災危険This chemical is combustible. (NTP, 1992)Combustible. Finely dispersed particles form explosive mixtures in air.
火災の可能性Combustible.
健康有害性Excerpt from NIOSH Pocket Guide for Trimellitic anhydride:
有害性の概要There are three syndromes caused by trimellitic anhydride (TMA) based on its ability to irritate and sensitize lung tissue. Sensitized workers can develop upon re-exposure 1) asthma-rhinitis2) late respiratory systemic syndrome (LRSS)or very rarely 3) pulmonary disease anemia syndrome (PDA). [Grammer LC et al. Review of trimellitic anhydride (TMA) induced respiratory response. Allergy Asthma Proc 1997 Jul-Aug18(4):235-7] Workers exposed to less than 0.002 mg/m3 are at low risk for developing disease. [Grammer LC et al. A Clinical and Immunologic Study to Assess Risk of TMA-Induced Lung Disease as Related to Exposure. JOEM 1999 Dec

用途

解説

C9H4O5(192.13)．トリメリト酸無水物，無水トリメリット酸ともいう．ベンゼン核に3個のカルボキシル基が1,2,4の位置についたものをトリメリト酸といい，このうち隣接したカルボキシル基から水を除去したものをいう．工業的製法には，1,2,4-トリメチルベンゼン(プソイドクメン)を酸化する方法，およびパラキシレンをクロロメチル化して酸化する方法などがある．白色の固体．融点166～168 ℃，沸点200 ℃(0.27 kPa)，250 ℃(2.1 kPa)．d"1.54．アセトンに可溶，キシレンに微溶．おもに塩化ビニル樹脂用可塑剤，耐熱性ポリイミド樹脂および水溶性塗料の原料として用いられる．森北出版「化学辞典（第2版）

用途

水溶性塗料、樹脂原料

用途

有機合成(可塑剤)原料。

用途

水溶性塗料、エステル系耐熱性可塑剤原料、ポリアミドイミド原料、エポキシ樹脂硬化剤、接着剤、安定剤、繊維処理剤、界面活性剤、染料、顔料

使用

Trimellitic Anhydride is mainly used as raw material for polyester resin,polyimide resin,plasticizer TOTM ,and also be used for producing heatproof & insulating,adhesive,surfactant, paint,synthesize dye materials etc. Trimellitic anhydride is used as an embossing agent for vinyl flooring and as a curing agent for epoxy resins. It is also used as an intermediate for the synthesis of surface coatings chemicals, adhesives, polymers, dyes printing inks, pharmaceuticals .

一般的な説明

1,2,4-Benzenetricarboxylic anhydride(TA) is a hydrophilic monomer with multipurpose usage; as a curing agent for epoxy based resins and as a plasticizer for polyvinyl chloride(PVC).

製法・合成法

合成方法

m-キシレンあるいはプソイドクメンのHF-BF触媒存在下でのCOによるカルボニル化反応により得られる2,4-ジメチルベンズアルデヒドを経由して合成される。

41(12):1048-51] TMAN is a potent sensitizer after inhalation of either dust or fume. It causes IgE and IgG mediated disease (asthma/rhinitis, late respiratory systemic syndrome, pulmonary disease anemia, and late arthralgia myalgia). Symptoms include sneezing, rhinitis, dry throat, watery eyes, conjunctivitis, and dyspnea. Dermal contact may cause or exacerbate respiratory sensitization. When workers are not exposed to >2 ug/m3, there are no cases of disease or IgG against TM-HAS (Human Serum Albumin), but there are still cases of non-diseased workers with IgE against TM-HAS (9% incidence). TMAN cause both immediate and delayed dermal sensitization in animal studies. [ACGIH] Danger of airway sensitization
[MAK] TMA skin testing provides an alternative and potentially more practical method for monitoring TMA-exposed workers for developing IgE sensitization. [PMID 21915071] See ACID ANHYDRIDES.
反応性グループAcids, Carboxylic
EC 分類Symbol: XnR: 37-41-42/43S: (2)-22-26-36/37/39
Special ReportsEuropean Chemicals BureauIUCLID Dataset, Benzene-1,2,4-tricarboxylic acid 1,2-anhydride (CAS No.552-30-7) (2000 CD-ROM edition). Contains information on usage patterns, toxicology, and ecological effects submitted by industry to the European Union. Available from the database query page: http://ecb.jrc.it/esis/esis.php as of August 28, 2006.
Reactivity ProfileTRIMELLITIC ANHYDRIDE reacts exothermically with water. This reaction is expected to be slow, but can become vigorous if local heating accelerates it. Reaction with water is accelerated by acids. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. Incompatible with strong oxidizing agents, strong acids or strong bases. (NTP, 1992).
Chemical DangersReacts violently with bases and oxidants. Reacts slowly with water. This produces trimellitic acid.
Flammable LimitsCombustible Solid
消火Fires involving this material should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)Use water spray, powder.
応急処置措置Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .
応急処置EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.(General first aid procedures)
安全保管Dry. Separated from bases and strong oxidants. Ventilation along the floor.
Firefighting Hazards... If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc ... A harmful concentration of airborne particles can be reached quickly when dispersed.
暴露管理・個人防護0.04 [mg/m3]
消火手順Water spray, powder.
保管条件Dry. Separated from bases and strong oxidants. Ventilation along the floor.
清掃方法Personal protection: P3 filter respirator for toxic particles. Sweep spilled substance into containersif appropriate, moisten first to prevent dusting. Carefully collect remainder.
非火災時の漏出対応SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
処分方法SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.
漏出処分Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder.
体内負荷Personal breathing zone samples from two workers in a 55-gallon drum manufacturing plant had an 8 hour exposure to trimellitic anhydride of 3.6 mg/cu-m and 1.7 mg/cu-m(1).
相互作用... Ozone (3 ppm for 3 hr) caused an increase in -log PC300 at 1 hr after exposure, with return of -log PC300 to control levels at 8 hr. Ozone also increased baseline RL at 8 hr. trimellitic anhydride (TMA) challenge increase -log PC300 in TMA-sensitized guinea pigs at 8 hr after challenge from 3.85 +/- 0.09 to 4.11 +/- 0.09. Ozone exposure prior to TMA challenge prevented the induction of airway hyperresponsiveness with a mean -log PC300 of 3.51 +/- 0.20, which was not different from that of control TMA-sensitized group. Baseline lung resistance was significantly higher in ozone-pretreated animals after TMA challenge when compared to those of either control or challenged with TMA alone. Ozone had no effect on TMA challenge-induced BAL eosinophilia and neutrophilia.... Before challenge, sensitized animals were pretreated iv with inhibitors of different mediators: pyrilamine (antihistamine: 2 mg/kg, indomethacin (cyclooxygenase inhibitor: 10 mg/kg), OKY-046 (thromboxane synthetase inhibitor: 30 mg/kg), ICI-198,615 (leukotriene receptor antagonist: 10-6 mol/kg), ketanserin (5-HT2 receptor antagonist: 1 mg/kg), or azelastine ("antiallergic agent": 1 mg/kg). Intratracheal instillation of trimellitic anhydride conjugated to guinea pig serum albumin (TMA-GPSA) induced a slowly progressing increase in lung resistance (RL) and produced extravasation of Evans blue dye at all airway levels in sensitized animals. Pyrilamine and azelastine abolished the increase in RL induced by TMA-GPSA until 2.5 min after the challenge. Indomethacin and OKY-046 significantly attenuated the increase in RL 3 min after the challenge. ICI-198,615 and ketanserin did not significantly affect the increase in RL. Extravasation of Evans blue dye induced by TMA-GPSA was decreased by pyrilamine, azelastine and ICI-198,615 in main bronchi and intrapulmonary airways. Indomethacin, OKY-046 and ketanserin did not significantly affect the extravasation of dye into the airway tissue.... Both IgE and IgG anti-trimellitic anhydride antibodies started to rise between weeks 1 and 3 after immunisation, reached their highest levels 7 weeks after sensitisation with 3% of TMA and then started to decline. Betamethasone and cyclosporin A (CsA) given orally over the time of sensitisation (8 days in total) inhibited the development of specific IgE and IgG anti-TMA antibodies. Betamethasone given 10-17 days after sensitisation attenuated the IgE and IgG antibody responses as well while treatment with CsA after sensitisation had no effect on the production of specific antibodies. Levels of total IgE and IgG were not affected except for a small decrease in total IgE using medium-dose betamethasone after sensitisation.... Guinea pigs pretreated with cobra venom factor (CVF) had significantly reduced amounts of complement component C3 in the lavage fluid 24 hours after trimellitic anhydride (TMA) conjugated to guinea pig serum albumin challenge. Pretreatment with CVF did not affect the immediate TMA-induced bronchoconstriction nor the TMA-induced microvascular leakage. In animals depleted of the complement system by pretreatment with CVF the TMA-induced increase in mononuclear cells, total white blood cells, red blood cells, and EPO activity in the bronchoalveolar lavage was significantly reduced.... Exposure to 0.5 mg/cu m trimellitic anhydride produced hemorrhagic foci of the lung and increased antibody levels in rats treated for six hours/day, five days/week for two weeks ... Estrogen treatment reduced the number of lung foci in both male and female rats, while testosterone treatment had no effect.
標的器官Eyes, skin, respiratory system
環境中動態TERRESTRIAL FATE: Based on the structural similarities to phthalic anhydride, trimellitic anhydride is expected to have a similar hydrolysis rate(SRC). Phthalic anhydride has been reported to hydrolyze rapidly in water(1) and estimated half-lives of approximately 1.5 minutes and 2.7 minutes were calculated(SRC) using reported observed rate constants of 7.9X10-3/sec(2) and 4.3X10-3/sec(3), respectively. Based upon this hydrolysis rate, trimellitic anhydride is expected to hydrolyze in moist soils(SRC). Volatilization from soil surfaces and adsorption to soil are not expected to be important processes because of hydrolysis(SRC).AQUATIC FATE: Based on the structural similarities to phthalic anhydride, trimellitic anhydride is expected to have a similar hydrolysis rate(SRC). Phthalic anhydride has been reported to hydrolyze rapidly in water(1) and estimated half-lives of approximately 1.5 minutes and 2.7 minutes were calculated(SRC) using reported observed rate constants of 7.9X10-3/sec(2) and 4.3X10-3/sec(3), respectively. Therefore, volatilization from water surfaces, adsorption to suspended solids and sediments, biodegradation, and bioconcentration of trimellitic anhydride are not expected to be important in aquatic systems based on hydrolysis(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimellitic anhydride, which has an extrapolated vapor pressure of 9.86X10-6 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase trimellitic anhydride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 20 days(SRC), calculated from its rate constant of 7.97X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase trimellitic anhydride may be physically removed from the air by wet and dry deposition(SRC).
有害作用Hemolytic anemia - Decreased hemoglobin or number of red blood cells.
暴露経路The substance can be absorbed into the body by inhalation and by ingestion.inhalation, ingestion, skin and/or eye contact
生態毒性抜粋/AQUATIC SPECIES/ No signs of toxicity were observed in Daphnia magna (water flea) exposed to TMA/TMLA nominal concentrations of 130, 220, 350, 600, or 1,000 mg/L for 48 hours under static conditions ... Based on measured concentrations, the 96 hr NOEC was > 792 mg/L./AQUATIC SPECIES/ No signs of toxicity were observed in Scenedesmes subspicatus (green algae) exposed to TMA/TMLA nominal concentrations of 62.5, 125, 250, 500, or 1,000 mg/L for 96 hours under static conditions ... Based on measured concentrations, the NOEC was > 739 mg/L./AQUATIC SPECIES/ No signs of toxicity were observed in Leuciscus idus melanotus (Golden Orfe) exposed to TMA/TMLA nominal concentrations of 130, 220, 350, 600, or 1,000 mg/L for 96 hours under static conditions ... Based on measured concentrations the 96 hour NOEC > 896 mg/L./AQUATIC SPECIES/ Because TMA rapidly hydrolyzes to form trimellitic acid (TMLA) in water, following pH adjustment TMLA and sodium trimellitate salts are the actual form of the chemical evaluated in aquatic toxicity tests.
Signs and SymptomsCough. Headache. Nausea. Shortness of breath. Wheezing. Symptoms may be delayed.Redness. Pain.Nausea. Abdominal pain. Burning sensation. Vomiting. Diarrhoea.irritation eyes, skin, nose, respiratory systempulmonary edema, resp sensitizationrhinitis, asthma, cough, wheezing, dyspnea (breathing difficulty), malaise (vague feeling of discomfort), fever, muscle aches, sneezing
Ongoing Test StatusThe following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=552-30-7]
Medical SurveillanceThis article described our clinical and immunologic experience in assessing workers exposed to trimellitic anhydride (TMA) in three industrial settings. Since 1977 /the authors/ have had engaged in a prospective study of workers involved at the site of manufacture of TMA. These studies demonstrate that serologic measurements of total antibody to trimellityl human serum albumin (TM-HSA) and IgE antibody to TM-HSA are predictive of the development of an immunologically mediated respiratory illness and are useful in monitoring workers removed from TMA exposure, in identifying asymptomatic workers who may be at risk in the future, and in defining the nature of sensitization of the work force. In a different industrial setting, /the authors/ have been able to study workers who mixed previously manufactured TMA powder with epoxy resins. This study indicated that clinical assessments by a plant physician with a standardized questionnaire, along with serologic tests, could establish the presence or absence of an immunologic respiratory illness caused by the inhalation of TMA dust. In a third industrial situation, workers were exposed to both TMA and phthalic anhydride (PA). Here workers were interviewed by a local physician with minimal experience with TMA-related respiratory illness. In this situation a more detailed questionnaire was utilized, along with serologic tests utilizing the enzyme-linked immunosorbent assay to establish the presence of a TMA- or PA-related syndrome. Immunologic studies demonstrated in workers exposed to both TMA and PA that the antibody responses elicited showed little crossreactivity between antibodies directed against TM-HSA or PA-HSA.... A practical approach that has significantly reduced the incidence of immune disease due to trimellitic anhydride is periodic surveillance of exposed worker populations with serum antibody studies and questionnaires. Workers who have significant levels of antibody, report significant symptoms on questionnaires, or both, are further evaluated to determine the clinical diagnosis and whether any interventions are needed.
Soil Adsorption/MobilityBased on the structural similarities to phthalic anhydride, trimellitic anhydride is expected to have a similar hydrolysis rate(SRC). Phthalic anhydride has been reported to hydrolyze rapidly in water(1) and estimated half-lives of approximately 1.5 minutes and 2.7 minutes were calculated(SRC) using reported observed rate constants of 7.9X10-3/sec(2) and 4.3X10-3/sec(3), respectively. Based upon this hydrolysis rate, trimellitic anhydride adsorption to soil and leaching are not expected to be important processes(SRC).
TSCA Test SubmissionsTrimellitic anhydride (CAS# 552-30-7) was evaluated for teratogenicity. The test substance was administered via inhalation to pregnant rats during gestation days 6-15 for 6/hrs/day at a concentration of 500 ug/cu m. Half of the animals were sacrificed for pathological evaluation and the other half were given a single "challenge" exposure of 500 ug/cu m for 6-hours. Pathological findings concluded there was a significant increased in the number of hemorrhagic lung foci and an increased level of trimellitic anhydride (TMA) specific serum antibody in all rats. There were no significant treatment-related differences in litter size, litter viability, variations, or malformations.Trimellitic anhydride (CAS# 552-30-7) was evaluated for teratogenicity. The test substance was administered via inhalation to pregnant guinea pigs during gestation days 6-26 for 6/hrs/day at a concentration of 500 ug/cu m. Half of the animals were sacrificed for pathological evaluation and the other half were given a single "challenge" exposure of 500 ug/cu m for 6-hours. Pathological findings concluded there was a significant increase in the number of hemorrhagic lung foci and an increased level of trimellitic anhydride (TMA) specific serum antibody in 2/7 guinea pigs. There were no significant differences in litter size, litter viability, variations, or malformations.Subchronic inhalation toxicity and sensitization potential were evaluated in groups of 15 rats (sex and strain not reported) exposed to a single 6-hour dose of trimellitic anhydride at a level of 0, 0.3, 1.6, 7.7, 23.9 or 135 micrograms/cu m with a second 6-hour dose to 500 micrograms/cu m 3 weeks later. The method of atmosphere generation and compound concentration measurement was not reported. There were no mortalities or clinical observations reported. Necropsy revealed a dose-dependent increase in hemorrhagic foci in the lungs of treated animals.
F10-21
職業暴露区分（OEB）D
職業暴露限界（OEL）TWA: 0.005 ppm (0.04 mg/m3) Should be handled in the workplace as an extremely toxic substance.
水環境危害等級（WGK）1
TSCA 収載状態TSCA listed
RTECS 番号DC2050000
毒性LD50 orally in Rabbit: > 2730 mg/kg LD50 dermal Rabbit 23000 mg/kg
PRTR法第一種指定化学物質
税関コード29173980
危険文句（R）37-41-42/43
化審法(3)-1362 優先評価化学物質
安衛法57,57-2
危険表示Xn
安全措置（S）22-26-36/37/39
危険等級Eye Dam. 1Resp. Sens. 1Skin Sens. 1STOT SE 3
貯蔵分類11 - Combustible Solids
有害物質データ552-30-7(Hazardous Substances Data)