ニュートラルレッド

Neutral Red

HCID 11105

基本情報

CAS
553-24-2
標準SMILES
Cc1cc2nc3ccc(N(C)C)cc3nc2cc1N.Cl
InChIKey
PGSADBUBUOPOJS-UHFFFAOYSA-N
分子式
C15H16N4.ClH
平均分子量
288.77 g/mol
単同位体質量
288.11417422

概要

Neutral red is a hydrochloride obtained by combining the free base of neutral red with one equivalent of hydrochloric acid. Neutral red acts as a pH indicator, changing from red to yellow between pH 6.8 and 8.0. It has a role as a dye, an acid-base indicator and a two-colour indicator. It contains a neutral red(1+).

名称と識別子

優先名称
Neutral Red
IUPAC
8-N,8-N,3-trimethylphenazine-2,8-diamine;hydrochloride
現地名
ニュートラルレッド
英語名
Neutral Red
分子式
C15H16N4.ClH
分子量
288.78

名称と別名

NEUTRAL RED553-24-2Toluylene Red3-Amino-7-dimethylamino-2-methylphenazine hydrochlorideC.I. Basic Red 5Neutral Red chlorideMichrome No. 226Neutral Red W2,8-Phenazinediamine, N8,N8,3-trimethyl-, monohydrochlorideC.I. 50040Cerven neutralniCerven toluylenova
名称をさらに表示
ニュートラル レッド 0.1% (約70% エタノール溶液)ベーシックレッド5N',N',3-トリメチル-2,8-フェナジンジアミン·塩酸塩ニュークリアファストレッド【塩基性染料】ニュクリアファーストレッド8-(ジメチルアミノ)-3-メチル-2-フェナジンアミン·塩酸塩ケルンエヒトロート3-メチル-8-(ジメチルアミノ)-2-フェナジンアミン·塩酸塩C.I.ベーシックレッド5ケルネクトロートヌクレアーファーストレッドトルイレンレッドニュートラルレッドWベイシックレッド5ニュートラルレッド溶液ニュートラルレッド (0.1%, 約70%エタノール溶液)ベーシックレッド5 ニュートラルレッドニュートラルレッド(NR)ニュートラルレッド 溶液ニュートラルレッド溶液(0.33%)Basic Red 5N2,N2,7-TriMethylphenazine-2,8-diaMine hydrochlorideKernechrotneutralredwc.i.basicred5michromeno.226cervenneutralnicervenzasadita5
C.I. Basic Red 5, monohydrochlorideCerven zasadita 5Aminodimethylaminotoluaminozine hydrochlorideNuclear Fast Red (basic dye)AI3-60242261QK3SSBHNSC-3092CHEBI:86370

データベース識別子

CAS
553-24-2
PubChem CID
11105
DTXSID
DTXSID90883440
ChEBI
CHEBI:86370
UNII
261QK3SSBH
EC Number
209-035-8

物性

構造計算による物性

極性表面積
55 Ų
水素結合供与体数
2
水素結合受容体数
4
回転可能結合数
1
重原子数
20

実験および物理化学的性質

Chemical ClassesDyes -> Azine Dyes
Physical DescriptionDark green solid; [Merck Index]

物理化学的性質

融点
290 °C · 290 °C (dec.) (lit.)
沸点
441.31 °C · 441.31°C (rough estimate)
比重(密度)
1.159 · 1.1590 (rough estimate)
屈折率
1.611 · 1.6110 (estimate)
貯蔵温度
5 °C · Store at +5°C to +30°C.
溶解性
2 O: · H2O: 可溶性10mg/mL

化学的性質

化学的特性dark green powder

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 11.1% (2 of 18) of reports.

Warning

H315 (77.8%): Causes skin irritation [Warning Skin corrosion/irritation]

P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 18 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 2 件

Chemical: 2,8-Phenazinediamine, N8,N8,3-trimethyl-, monohydrochloride

Phenazine, 3-amino-7-(dimethylamino)-2-methyl-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryA skin, eye, and respiratory tract irritant; [MSDSonline]
Hazard Classes and CategoriesSkin Irrit. 2 (77.8%)

安全データ

wgk
3
tsca
TSCA listed
rtecs
SG1400000
毒性
LD50 intraperitoneal in mouse: 432mg/kg
hs_code
32041300
risk_code
68-36/37/38

化学と産業

薬理情報

MeSH Pharmacological Classification · 2 件

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.

用途と製造

UsesUsed as an indicator, biological stain, and drug; [ChemIDplus] Used to prepare neutral-red paper; [Merck Index] Azine dye; [Kirk-Othmer]
General Manufacturing Information2,8-Phenazinediamine, N8,N8,3-trimethyl-, hydrochloride (1:1): ACTIVE
応用分野 · 4 件

解説3-amino-7-dimethylamino-2-methylphenazine hydrochloride.C15H17ClN4(288.78).m-トルイレンジアミンにp-ニトロソジメチルアニリンを作用させ,得られたインダミンを酸化すると得られる.暗緑色の粉末.水,エタノールに可溶.pH 6.8で赤色,pH 8.0で黄色を呈する.酸塩基指示薬.0.1% の60% エタノール溶液は,水,尿素,亜硝酸などのアルカリ度を測定するための滴定指示薬に用いられる.ニュートラルレッド紙,生細胞の生化学的染色に利用される.森北出版「化学辞典(第2版)

用途有機合成原料。

使用Neutral Red is a common histology stain used to determine cell viability. It is also used as indicator for nitrogen determination; pH indicator; Dyes and metabolites.

一般的な説明Neutral red (C.I. 50040) is a protonated diaminophenazine dye. It is aminodimethylaminomethylphenazinehydrochloride, C15H17N4Cl.

調製方法

製造方法(a) N,N-dimethyl-4-nitrosobenzenamineand 4-Methylbenzene-1,3-diaminereaction, form Toluylene Blue (Basic Dye, C.I. 49410), heating make cyclization; (b) oxidation N1,N1-dimethylbenzene-1,4-diamine, and 4-Methylbenzene-1,3-diamine mixture.

純化方法In aqueous solution it is red at pH 6.8 and yellow at pH 8.0. [Beilstein 25 III/IV 3054.]

サプライヤー100 社

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補足説明 · 1 件

定義ChEBI: Neutral red is a hydrochloride obtained by combining the free base of neutral red with one equivalent of hydrochloric acid. Neutral red acts as a pH indicator, changing from red to yellow between pH 6.8 and 8.0. It has a role as a dye, an acid-base indicator and a two-colour indicator. It contains a neutral red(1+).

関連反応

3 件

化合物ノート

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