りん酸 トリ-m-クレジル

This compound is not very flammable but any fire involving this compound may produce dangerous vapors. You should evacuate the area. All firefighters should wear full-body protective clothing and use self-contained breathing apparatuses. You should extinguish any fires involving this chemical with a dry chemical, carbon dioxide, foam, or halon extinguisher. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Tricresyl phosphates should be stored in a cool, well ventilated area, protected from direct sunlight and away from open flames. Containers should be made of galvanized steel; these should be effectively sealed and their contents clearly marked. Tricresyl phosphates should not be used in plastic articles which are likely to come into contact with foodstuffs or clothing. /Tricresyl phosphates/

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with toluene followed by washing with a strong soap and water solution. Do no reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Absorb with paper towels. Place in a plastic bag. Burn in ... furnace. /Tricresyl phosphate/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Prolonged skin or mucous membrane contact should be avoided by use of mechanized processes, protective clothing (including gloves and goggles) and barrier creams; in addition, scrupulous personal hygiene should be encouraged ... /Tricresyl phosphates/

Where a process entails the heating of tricresyl phosphate, exhaust ventilation should be installed to collect vapors at source or, under special circumstances, workers may be required to wear respiratory protective equipment; a high standard of general ventilation for the workplace is also necessary, and atmospheric determinations should be carried out at regular intervals to ensure that the concentration of tri-o-cresyl phosphate in air is maintained below recommended permissible levels. /Tricresyl phosphates/

Workers should not be allowed to eat, drink or smoke at the workplace. /Tricresyl phosphates/

... Ingestion must be prevented & breathing of vapors must not be continuous ... /isomeric mixt/

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

Wear safety glasses, gas mask, long-sleeve coveralls with tight collars and cuffs, gloves, and boots. /Tricresyl phosphate/

Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 4.4X10+4(SRC), determined from a structure estimation method(2), indicates that tri-m-cresyl phosphate is expected to be immobile in soil(SRC). Volatilization of tri-m-cresyl phosphate from moist soil surfaces is expected occur(SRC) given an estimated Henry's Law constant of 1.0X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(2). However, adsorption to soil is expected to attenuate volatilization. Tri-m-cresyl phosphate is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 7.8X10-7 mm Hg(SRC), determined from a fragment constant method(2). Biodegradation of tri-m-cresyl phosphate in soil is expected to be an important fate process(SRC), based on its ready biodegradability in water and sediments(3-5).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 4.4X10+4(SRC), determined from a structure estimation method(2), indicates that tri-m-cresyl phosphate is expected to adsorb to suspended solids and sediment in water(SRC). Tri-m-cresyl phosphate has been observed to adsorb to sediment in the water column and precipitate to the bottom in sorption studies(3). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 1.0X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 70 and 518 days, respectively(SRC). Strong adsorption to sediment may attenuate the rate of volatilization(SRC). According to a classification scheme(5), bioconcentration factors of 784 and 596 determined in rainbow trout and fathead minnows(6), suggest that bioconcentration in aquatic organisms is high(SRC). A base-catalyzed second-order hydrolysis rate constant of 0.12 L/mole-sec(SRC) and a neutral hydrolysis rate constant 6.5X10-7/day were estimated using a structure estimation method(1); this corresponds to half-lives of 1.8 years, 66 days, 6.6 days and 16 hours at pH values of 7, 8, 9 and 10, respectively(2). The half-life of tri-m-cresyl phosphate in lake water, river water and sediment bottoms has been observed to range from less than 4 days to 16 days with biodegradation being the prime fate process(7-10).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tri-m-cresyl phosphate, which has an estimated vapor pressure of 7.8X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase tri-m-cresyl phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 13 hours(SRC), calculated from its rate constant of 2.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Monitoring studies have observed that tri-m-cresyl phosphate is removed from the atmosphere by both wet and dry deposition(3). Tri-m-cresyl phosphate does not absorb UV wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

/AQUATIC SPECIES/ Rainbow trout exposed to lubricating oil composed of triaryl phosphate developed symptoms of chronic poisoning. Activities of glutamic-oxaloacetic transaminase and lactate dehydrogenase in serum were elevated and internal fatty tissues became discolored. /Triaryl phosphates/

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of October 25, 2012: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=563-04-2]

The concentration of tri-m-cresyl phosphate in wastewater discharged from industrial machinery complex into the Kurose River, Hiroshima, Japan, ranged from 0.09 to 0.51 ug/L. The concentration of tri-m-cresyl phosphate in domestic wastewater from Hiroshima, Japan ranged from 0.11 to 0.32 ug/L(1).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for tri-m-cresyl phosphate can be estimated to be 4.4X10+4(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that tri-m-cresyl phosphate is expected to be immobile in soil(SRC). Tri-m-cresyl phosphate was found to adsorb strongly to clay minerals in sorption tests(3). Using bottom sediment from a river, tri-m-cresyl phosphate was found to adsorb strongly to the sediment with a Freundlich isotherm constant of 364(4); it was further observed that tri-m-cresyl phosphate in the water column adsorbed to sediment and precipitated to the bottom(4).

URBAN/SUBURBAN: Tri-m-cresyl phosphate concentrations of 0.039 to 0.085 ng/cu m were detected in atmospheric samples collected from the Kurose river basin Japan during 1995 monitoring(1).

... TRITOLYL PHOSPHATE CONCN IN AIR OF FACTORY WHERE 3 CASES OF POLYNEURITIS OCCURRED ... & VARIOUS SAMPLES TAKEN IN THIS ATMOSPHERE SHOWED CONCN BETWEEN 0.55 MG/CU M & 1.66 MG/CU M. /ISOMERIC MIXT/

/SIGNS AND SYMPTOMS/ ... CHRONIC TOXICITY OF TRITOLYL PHOSPHATE, WHEN THERE WAS SIMULTANEOUS INHALATION & CUTANEOUS ABSORPTION. MAIN SYMPTOMS WERE HYPERHYDROSIS, HYPOTENSION, GENERAL FATIGUE, AFFECTIVE IRRITABILITY, & PARESTHESIA IN LIMBS. /ISOMERIC MIXT/

/SIGNS AND SYMPTOMS/ EFFECT ON WORKERS PRODUCING TRIARYL PHOSPHATES IS CHARACTERIZED BY PERIVASCULAR FORM OF POLYNEURITIS, DECR ACTIVITY OF PLASMA CHOLINESTERASE & CHRONIC GASTRITIS WITH DEFICIENT SECRETION, TOXIC ENCEPHALOPATHY, HYPOTHALAMIC SYNDROME, & POLYNEURITIS. /TRIARYL PHOSPHATES/

/SIGNS AND SYMPTOMS/ ... ABSORPTION OF TRITOLYL PHOSPHATE THROUGH SKIN GIVES RISE ONLY TO ATTACK ON PERIPHERAL NERVES, WHILE BREATHING VAPORS IS FOLLOWED, IN PARTICULAR, BY ATTACK ON PYRAMIDAL TRACT. /ISOMERIC MIXT/

/CASE REPORTS/ CASE OF PERMANENT PARALYSIS IN MAN ENGAGED IN MANUFACTURING META & PARA ISOMERS OF TRICRESYL PHOSPHATE ... FINAL PRODUCT CONTAINED ONLY 1% TOCP /TRI-O-CRESYL PHOSPHATE/-, AS MUCH AS 6 TO 10% WAS PRESENT AS CONTAMINANT DURING MANUFACTURING. ... PATIENT HAD WORKED ... 5 MO ... BEFORE SYMPTOMS OF ANOREXIA, NAUSEA, & ACHING OF LEGS HAD DEVELOPED.

For more Human Toxicity Excerpts (Complete) data for TRI-M-CRESYL PHOSPHATE (6 total), please visit the HSDB record page.

Tri-m-cresyl phosphate's production and use as a plasticizer in vinyl plastic manufacture, as a flame retardant, gasoline additive, heat exchange medium, solvent for nitrocellulose, and in hydraulic fluids(1,2) may result in its release to the environment through various waste streams(SRC). Rainfall and runoff from agricultural plastic films has been identified as a source of environmental release of tri-m-cresyl phoshate(3,4). Tri-m-cresyl phosphate has been detected in exhaust gases from gasoline, diesel and motorcycle engines(5).

AEROBIC: Biodegradation of tri-m-cresyl phosphate in river water and bottom sediment followed first-order kinetics(1). The first-order rate constant in river water ranged from approximately 0.0022 per hour at 14 °C to 0.010 per hour at 20 °C(1); this corresponds to a half-life of about 13 days at 14 °C and 2.9 days at 20 °C(SRC). The first-order rate constant in bottom sediment ranged from approximately 0.0036 per hour at 14 °C to 0.0053 per hour at 25 °C(1); this corresponds to a half-life of about 8 days at 14 °C and 5.4 days at 25 °C(SRC). The observed rate constant for the biodegradation of C-14 ring-labeled tri-m-cresyl phosphate in river bottom sediments at 25 °C was 0.003 per hour(1), this corresponds to a half-life of about 9.6 days(SRC). In biodegradation tests using an activated sludge seed, tri-m-cresyl phosphate was observed to be biodegradable(2). In sediment-water incubation systems, the half-life of tri-m-cresyl phosphate in pond sediment was 3.2, 4.1, and 16.3 days at 25, 10, and 2 °C, respectively; the half-life in river sediment was 10.1 days at 25 °C(3). Polar degradation products of tri-m-cresyl phosphate consisted almost entirely of di-m-cresyl phosphate(3). The half-lives of tri-m-cresyl phosphate in bottom sediments and water of an artificial pond were about 39 days and 0.57 days, respectively(4).

Tri-m-cresyl phosphate was detected in bottom sediment from the Kurose River, Japan at concentrations ranging from 0.01 ug/g in April 1992 to 0.07 ug/g in October 1992. Tri-m-cresyl phosphate was also detected in suspended sediment from the Kurose River, Japan at concentrations of 0.11, 0.06, and 0.08 ug/l in October 1992, January 1992, and April 1992, respectively(1).

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Phosphoric acid, tris(3-methylphenyl) ester is included on this list. Effective date: 10/4/82; Sunset date: 10/4/92.

Used in a isomeric mixture known as Tricresyl phosphate (CAS # 1330-78-5); No uses for the isolated isomer; [HSDB]

Plasticizer in vinyl plastics mfr; flame-retardant; solvent for nitrocellulose; in cellulosic molding compositions; as additive to extreme pressure lubricants; non-flammable fluid in hydraulic systems; as lead scavenger in gasoline; to sterilize certain surgical instruments /Isomeric mixture/

Air filter medium; solvent mixtures; waterproofing; heat exchange medium. /Isomeric mixt/

Aryl phosphates such as tricresyl phosphate ... when added in small percentages to the gasoline, combat misfires. /Aryl phosphates/

A typical phosphate, tricresyl phosphate, is made by heating phosphorus oxychloride with cresol ... . /Tricresyl phosphate/

Prepared from cresol and phosphorus oxychloride, phosphoric acid, or phosphorus pentachloride. The grades of cresol commonly used are the isomeric (o-, m-, p-), and meta-para mixtures from coal tar and cresylic acid from petroleum. Purification of the product is based on the intended use; the commercial product is generally obtained as a mixture. A "refined grade" of tricresyl phosphate is prepared by vacuum distillation, or alternatively by washing with 2% sodium hydroxide and water ... . /Tricresyl phosphate/

Phosphoric acid, tris(3-methylphenyl) ester: ACTIVE

TRICRESYL PHOSPHATE SHOULD NOT BE USED IN PLASTIC ARTICLES WHICH ARE LIKELY TO COME INTO CONTACT WITH FOODSTUFFS OR CLOTHING. /ISOMERIC MIXT/

A tricresyl phosphate prepared from m- or p-cresol has the same properties as the technical product, but the cost of separating and purifying these isomers is prohibitive. /Isomeric mixt/

... A) ARYL PHOSPHATES ... NOT SUITABLE FOR PLASTICS IN CONTACT WITH FOODSTUFFS; C) ... SHOULD NOT BE USED IN ARTICLES INTENDED FOR WEAR DIRECTLY ON SKIN OR ARTICLES ... HANDLED BY CHILDREN. /ARYL PHOSPHATES/