基本情報
- CAS
569-59-5- 標準SMILES
CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12.O=C(O)[C@H](O)[C@@H](O)C(=O)O- InChIKey
WFXURHIXPXVPGM-LREBCSMRSA-N- 分子式
- C23H25NO6
- 平均分子量
- 411.4 g/mol
- 単同位体質量
- 411.16818752
概要
See also: Phenindamine (has active moiety).
名称と識別子
- 優先名称
- Phenindamine Tartrate
- IUPAC
- (2R,3R)-2,3-dihydroxybutanedioic acid;2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
- 現地名
- 酒石酸フェニンダミン
- 英語名
- phenindamine tartrate
- 分子式
- C19H19N.C4H6O6
- 分子量
- 411.452
名称と別名
Phenindamine tartratePernovinePhenindamine bitartratePhenindamine hydrogen tartratePernovin569-59-528725X3PV8Thephorin tartrate1H-INDENO(2,1-c)PYRIDINE, 2,3,4,9-TETRAHYDRO-2-METHYL-9-PHENYL-, TARTRATE (1:1)NSC-915262,3,4,9-TETRAHYDRO-2-METHYL-9-PHENYL-1H-INDENO(2,1-C)PYRIDINE TARTRATERefChem:172695
名称をさらに表示
酒石酸フェニンダミンフェニンダミン・L-酒石酸
209-320-7Phenindamine tartrate [USAN]NolahistPhenindamine tartrate (USAN)Nolahist (TN)EINECS 209-320-7NSC 91526UNII-28725X3PV8
データベース識別子
- CAS
569-59-5- PubChem CID
- 11290
- ChEMBL
CHEMBL2107213- UNII
- 28725X3PV8
- EC Number
- 209-320-7
物性
構造計算による物性
- 極性表面積
- 118 Ų
- 水素結合供与体数
- 4
- 水素結合受容体数
- 7
- 回転可能結合数
- 4
- 重原子数
- 30
- 形式電荷
- 0
- 複雑度
- 524
物理化学的性質
- 融点
- 160 ° · 160°
- 溶解性
- 96 · 水に溶けにくく、エタノール（96％）に溶けにくく、エーテルにほとんど溶けない。
化学的性質
化学的特性A white or almost white, voluminous powder.
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P264+P265, P270, P280, P301+P316, P305+P354+P338, P317, P321, P330, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
危険有害性情報
Hazard Classes and CategoriesAcute Tox. 3 (100%)
安全データ
- 毒性
- LD50 in mice (mg/kg): 27 i.v., 170 i.p., 265 orally (Schallek)
化学と産業
薬理情報
MeSH Pharmacological Classification
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
応用分野
使用Histamine H1 receptor antagonist; antihistamine.
一般的な説明Phenindamine tartrate,2,3,4,9-tetrahydro-2-methyl-9-phenyl-1H-indeno[2, 1-c]pyridine bitartrate, occurs as a creamy-white powder, usuallywith a faint odor and sparingly soluble in water (1:40). A 2%aqueous solution has a pH of about 3.5. It is most stable inthe pH range of 3.5 to 5.0 and is unstable in solutions of pH 7or higher. Oxidizing substances or heat may cause isomerizationto an inactive form.Structurally, phenindamine can be regarded as an unsaturatedpropylamine derivative, in that the rigid ring systemcontains a distorted, trans-alkene. Like the other commonlyused antihistamines, it may produce drowsiness and sleepiness;it may also cause a mildly stimulating action in somepatients and insomnia when taken just before bedtime.
上流・下流製品情報
上流原料
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