基本情報
- CAS
82-88-2- 標準SMILES
CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12- InChIKey
ISFHAYSTHMVOJR-UHFFFAOYSA-N- 分子式
- C19H19N
- 平均分子量
- 261.4 g/mol
- 単同位体質量
- 261.15174961
概要
Phenindamine is an indene.
名称と識別子
- 優先名称
- Phenindamine
- IUPAC
- 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
- 現地名
- フェニンダミン
- 英語名
- phenindamine
- 分子式
- C19H19N
- 分子量
- 261.36
名称と別名
PhenindamineThephorin82-88-2FenindaminaPhenindaminum772BQ8KSSTNU-15042,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridine1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-DTXSID00234521H-Indeno[2,1-c]pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno[2,1-c]pyridine
名称をさらに表示
フェニンダミン2,3,4,9-テトラヒドロ-9-(フェニル)-2-メチル-1H-インデノ[2,1-c]ピリジンテホリン2,3,4,9-テトラヒドロ-2-メチル-9-フェニル-1H-インデノ[2,1-c]ピリジン2-メチル-9-フェニル-1H,2H,3H,4H,9H-インデノ[2,1-c]ピリジンphenindamine USP/EP/BPPhenindamine Hydrogen Tartrate2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine1H-Indeno2,1-cpyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-
2-METHYL-9-PHENYL-1H,2H,3H,4H,9H-INDENO[2,1-C]PYRIDINE2-methyl-9-phenyl-1H,2H,3H,4H,9H-indeno(2,1-c)pyridineRefChem:172693DTXCID403452R06AX042,3,4,9-tetrahydro-2-methyl-9-phenyl-lH-indeno-(2,1-c)pyridine201-443-4Fenindamina [INN-Spanish]
物性
構造計算による物性
- XLogP
- 3.1
- 極性表面積
- 3.2 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 1
- 回転可能結合数
- 1
- 重原子数
- 20
- 形式電荷
- 0
- 複雑度
- 391
実験および物理化学的性質
Solubility2.77e-02 g/L
Human Drugs
Breast Feeding; Lactation; Milk, Human; Antihistamines
Pharmaceuticals
Melting Point91 °C
Physical DescriptionSolid
物理化学的性質
- 融点
- 90 · 90-91°
- 比重(密度)
- 1.17 · 1.17
- 酸解離定数(Pka)
- 8.11 · pKa 8.11±0.08(H2O,t undefined,I=0.30(NaCl)) (Uncertain)
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
危険有害性情報
Regulatory Information1H-Indeno2,1-cpyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-: Does not have an individual approval but may be used under an appropriate group standard
毒性情報
Toxicity Summary
Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Signs and SymptomsSymptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
化学と産業
薬理情報
ATC Code
R - Respiratory system
QR - Respiratory system
Pharmacodynamics
Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Allergies are caused by an excessive type 1 hypersensitivity response of the body to allergens, mediated by inappropriate histamine signalling. By inhibiting the binding of histamine, antihistamines decrease the normal histamine response from cells, consequently decreasing allergic symptoms.
Mechanism of Action
Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
MeSH Pharmacological Classification
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Cellular LocationsMembrane
Metabolite PathwaysPhenindamine H1-Antihistamine Action
用途と製造
UsesUsed to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.
関連反応
0 件
現在のフィルター条件では反応記録がありません。
化合物ノート
読み込み中…