塩酸イソクスプリン
塩酸イソクスプリン · イソクスプリン塩酸塩 · イソクスプリン 塩酸塩 · イソクスプリン塩酸塩 (JP17) · イソクスプリン・塩酸塩 · ズファジラン · ISOXSUPRINE HCL · Isoxsuprine
識別子と物理属性
| CAS No. | 579-56-6 |
|---|---|
| 分子式 | C18H24ClNO3 |
| 平均分子量 | 337.847 g/mol |
| 単同位体質量 | 337.14447131 g/mol |
| SMILES | CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1.Cl |
| InChIKey | QVPSGVSNYPRFAS-UHFFFAOYSA-N |
| PubChem CID | 11368 |
| ChEMBL | CHEMBL559180 |
| ChEBI | CHEBI:31735 |
| EC No. | 209-443-6 |
| DTXSID | DTXSID1045328 |
| 現地名 | 塩酸イソクスプリン |
化学・物理的性質
| 融点 | 203-204° |
|---|---|
| 貯蔵条件 | Inert atmosphere,2-8°C |
| 溶解度 | 水またはエタノール（96%）にやや溶けにくく、塩化メチレンにほとんど溶けない。 |
| 外観・状態 | Solid |
| pKa（酸解離定数） | pKa 8.0 (Uncertain)9.8 (Uncertain) |
| 色 | White to off-white |
| 主な用途 | 法医学と毒物学医薬品（低分子化合物）獣医 |
| InChI | 1S/C18H23NO3.ClH/c1-13(12-22-17-6-4-3-5-7-17)19-14(2)18(21)15-8-10-16(20)11-9-15/h3-11,13-14,18-21H,12H2,1-2H3 |
| InChIKey | QVPSGVSNYPRFAS-UHFFFAOYSA-N |
| SMILES | OC(C(NC(COC1=CC=CC=C1)C)C)C2=CC=C(O)C=C2.Cl |
| CAS データベース | 579-56-6(CAS DataBase Reference) |
化学的特性
White Solid
安全性と法規制
| 水環境危害等級（WGK） | 3 |
|---|---|
| RTECS 番号 | DO8225000 |
| 輸送番号（UN） | UN 3077 9 / PGIII |
| 毒性 | LD50 in rats (mg/kg): 1750 orally164 i.p. (Goldenthal) |
| 税関コード | 2922504500 |
| 危険文句（R） | 22-50/53-63-50 |
| 危険表示 | Xn,N |
| 安全措置（S） | 36-61-60 |
| 危険等級 | Acute Tox. 4 OralAquatic Acute 1Aquatic Chronic 1 |
| 貯蔵分類 | 11 - Combustible Solids |
| 有害物質データ | 579-56-6(Hazardous Substances Data) |
用途
説明
Isoxsuprine is an adrenergic receptor modulator that has α-adrenergic receptor (α-AR) antagonist and β-AR agonist properties. It induces vasodilation of isolated equine common digital artery strips precontracted with norepinephrine, indicating an α-AR effect, and induces relaxation of isolated fowl cecum, an effect that can be blocked by the β-AR antagonist propranolol (Item Nos. 23349 | 17291). Isoxsuprine has antinociceptive effects in an acetic acid writhing test in mice. It also inhibits oxytocin-induced contractions in isolated rat uterus (IC50 = 9.15 μM). It delays labor onset in rats by 31.63 hours when administered at a dose of 10 mg/kg per day on days 13 to 21 of gestation but increases heart rate with increasing concentration.
使用
As a vasilodator drug, Isoxsuprine Hydrochloride is used in veterinary medicine for the treatment of navicular syndrome and laminitis in horses. Isoxsuprine Hydrochloride has been shown to be a β-adrenoreceptor antagonist with β-adrenoreceptor agonistic properties, with both characteristics contributing to vasodilation and uterine relaxation. Studies suggest that Isoxsuprine Hydrochloride may be useful as a as a tocolytic agent in the treatment of preterm labour.