基本情報
- CAS
73231-34-2- 標準SMILES
CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1- InChIKey
AYIRNRDRBQJXIF-NXEZZACHSA-N- 分子式
- C12H14Cl2FNO4S
- 平均分子量
- 358.2 g/mol
- 単同位体質量
- 357.00046251
概要
Florfenicol is a carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture. It has a role as an antimicrobial agent. It is a secondary carboxamide, a secondary alcohol, a sulfone, an organochlorine compound and an organofluorine compound. It is functionally related to a dichloroacetic acid.
名称と識別子
- 優先名称
- Florfenicol
- IUPAC
- 2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
- 現地名
- フロルフェニコール標準品
- 英語名
- FLORFENICOL
- 分子式
- C12H14Cl2FNO4S
- 分子量
- 358.21
名称と別名
Florfenicol73231-34-2Nuflor(-)-FlorfenicolSch-25298Sch 25298Nuflor gold2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamideDTXSID9045500Acetamide, 2,2-dichloro-N-((1S,2R)-1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)-D-threo-2,2-Dichloro-N-(alpha-(fluoromethyl)-beta-hydroxy-p-(methylsulfonyl)phenethyl)acetamide9J97307Y1H
名称をさらに表示
フロルフェニコール標準品FLORFENICALFLEROXACINLACTATEAQUAFENorfenicoLAquafen NuflorFlorfenicol APIFlorfenicol98%MinFlorfenicol, 98.5%
NSC-759287Acetamide, 2,2-dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]-DTXCID7025500CHEBI:87185OSURNIA COMPONENT FLORFENICOLZELERIS COMPONENT FLORFENICOL2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamideAquaflor
物性
構造計算による物性
- XLogP
- 0.8
- 極性表面積
- 91.9 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 5
- 回転可能結合数
- 6
- 重原子数
- 21
- 形式電荷
- 0
- 複雑度
- 447
実験および物理化学的性質
Drugs
Pharmaceuticals -> Antibiotics
Pharmaceuticals -> Antibiotics (Amphenicols)
Pharmaceuticals -> Anti infectives for systemic use -> Antibacterials for systemic use
LogP0.96
Animal Drugs
Active Ingredients (Florfenicol) -> FDA Greenbook
Pharmaceuticals -> UK Veterinary Medicines Directorate List
Collision Cross Section
170.7 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
169.78 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
170.95 Ų [M+Na]+
物理化学的性質
- 融点
- 153 °C · 153°C
- 外見
- 個体
安全と法規制
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 4% (4 of 101) of reports.
Danger
H361 (92.1%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
P203, P260, P264, P270, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 101 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.
危険有害性情報
Regulatory InformationFlorfenicol: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and Categories
Acute Tox. 4 (50%)
Repr. 2 (92.1%)
安全データ
- wgk
- 3
- hs_code
- 29419090
- safety_code
- 24/25
化学と産業
薬理情報
ATC Code
QJ - Antiinfectives for systemic use
QJ - Antiinfectives for systemic use
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
用途と製造
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
応用分野
使用anticholinergic, antiparkinsonian
サプライヤー100 社
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
湖北威德利化学试剂有限公司181-6332-1995 18062128043 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
清宁生物（江苏博泉生物科技有限公司）19352250998 · [email protected]
湖北海克斯生化有限公司
関連反応
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