N-アセチル-S-(ゲラニルゲラニル)-L-システイン
N-アセチル-S-[(2E,6E,10E)-3,7,11,15-テトラメチル-2,6,10,14-ヘキサデカテトラエニル]-L-システイン · (2R)-2-アセトアミド-3-{[(2E,6E,10E)-3,7,11,15-テトラメチルヘキサデカ-2,6,10,14-テトラエン-1-イル]スルファニル}プロパン酸 · N-アセチル-S-(ゲラニルゲラニル)-L-システイン · AGGC · PKFBJSDMCRJYDC-GEZSXCAASA-N · N-Acetyl-S-geranylgeranyl-L-cysteine · N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) · N-ACETYL-S-GERANYLGERANYL-L-CYSTEINE USP/EP/BP
識別子と物理属性
| CAS No. | 139332-94-8 |
|---|---|
| 分子式 | C25H41NO3S |
| 平均分子量 | 435.674 g/mol |
| 単同位体質量 | 435.28071517 g/mol |
| SMILES | CC(=O)N[C@@H](CSC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CCC=C(C)C)C(=O)O |
| InChIKey | PKFBJSDMCRJYDC-GEZSXCAASA-N |
| PubChem CID | 11575713 |
| ChEMBL | CHEMBL1407110 |
| ChEBI | CHEBI:191062 |
| DTXSID | DTXSID101370809 |
| 現地名 | N-アセチル-S-(ゲラニルゲラニル)-L-システイン |
化学・物理的性質
| 沸点 | 617.5±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.013±0.06 g/cm3(Predicted) |
| 貯蔵条件 | −20°C |
| 溶解度 | 0.1 M Na2CO3: 11 mg/mlDMF: 50 mg/mlDMSO: 33 mg/mlEthanol: 50 mg/ml |
| 外観・状態 | エタノール溶液 |
| pKa（酸解離定数） | 3.31±0.10(Predicted) |
安全性と法規制
| 水環境危害等級（WGK） | 1 |
|---|---|
| 輸送番号（UN） | UN 1170 3/PG 2 |
| 危険文句（R） | 11 |
| 危険表示 | F |
| 安全措置（S） | 7-16 |
用途
説明
N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.
使用
N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.