7-メチルキノリン

7-Methylquinoline

HCID 11927CAS 612-60-2

基本情報

標準SMILES
Cc1ccc2cccnc2c1
InChIKey
KDYVCOSVYOSHOL-UHFFFAOYSA-N
分子式
C10H9N
平均分子量
143.18 g/mol
単同位体質量
143.07349929

概要

7-methylquinoline appears as clear yellow liquid or oil. (NTP, 1992)

名称と識別子

優先名称
7-Methylquinoline
IUPAC
7-methylquinoline
現地名
7-メチルキノリン
英語名
7-Methylquinoline
分子式
C10H9N
分子量
143.19

名称と別名

7-METHYLQUINOLINE612-60-2m-ToluquinolineQuinoline, 7-methyl-CCRIS 2895DTXSID5025657EINECS 210-316-2UNII-EOW995K43CNSC 65665BRN 0110317EOW995K43CAI3-00850
名称をさらに表示
7-メチルキノリンm-トルキノリン7-メチルキノリン (~25%5-体含む)7‐メチルキノリン7-メチルキノリン (M-TOLUQUM-トルキノリンOOCTANE (1000ΜG/ML)7-methyquinoline7-Methylchinolin7-methyl-quinolin7-Methylquinolinol7-MethylquiuolineQuinolinol,7-methyl-7-Methylquinoline>
NSC-65665METHYLQUINOLINE, 7-DTXCID0056575-20-07-00402 (Beilstein Handbook Reference)mToluquinolineQuinoline, 7methylRefChem:106391210-316-2

データベース識別子

CAS
612-60-2
PubChem CID
11927
DTXSID
DTXSID5025657
ChEMBL
CHEMBL1322524
UNII
EOW995K43C
EC Number
210-316-2
Nikkaji
J842G

物性

構造計算による物性

XLogP
2.5
極性表面積
12.9 Ų
水素結合供与体数
0
水素結合受容体数
1
回転可能結合数
0
重原子数
11

実験および物理化学的性質

Chemical ClassesNitrogen Compounds -> Quinolines
SpringerMaterials PropertiesBoiling point
LogP2.47
Density1.0609 at 68 °F (NTP, 1992) - Denser than water; will sink
Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Flash Point230 °F (NTP, 1992)

物理化学的性質

融点
35 · 35-37 °C(lit.)
沸点
258 °C · 258 °C(lit.)
比重(密度)
1.061 · 1.061
屈折率
1.607 to · 1.6070 to 1.6210
闪点
230 °F · >230 °F
貯蔵温度
Room Temperature

化学的性質

化学的特性white to light yellow crystal powder

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 45 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

DOT LabelCorrosive
Fire HazardsThis chemical is combustible. (NTP, 1992)
Health HazardsSYMPTOMS: This compound may be absorbed through the skin and it causes skin irritation. The vapor or mist is irritating to the eyes, mucous membranes and upper respiratory tract.
Hazards SummaryA skin irritant; Vapor or mist causes eye, mucous membranes, and upper respiratory tract irritation; May be absorbed through skin; [NTP] An irritant; Risk of irreversible adverse health effects; [Alfa Aesar MSDS] See Quinoline.
Reactive GroupAmides and Imides
Reactivity Profile · 1 件

7-METHYLQUINOLINE may be sensitive to exposure to light. May react vigorously with strong oxidizing agents and strong acids (NTP, 1992). Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

安全と保護具

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

安全データ

wgk
3
tsca
TSCA listed
rtecs
VC0560000
hs_code
29334900
risk_code
37/38-41
化審法
(5)-796

化学と産業

用途と製造

General Manufacturing InformationQuinoline, 7-methyl-: ACTIVE
応用分野 · 2 件

使用7-methylquinoline has been bioassayed as tumor initiator on the skin of Sencar mice.

一般的な説明7-Methylquinoline is a reagent used in the preparation of diarylmethylpiperazines as potent opioid receptor agonists with improved side effects. Also used in the preparation of novel pyrazine compounds derived from 2-phenylquinolin-7-yl which act as potent insulin-like growth factor-I receptor inhibitors.

調製方法

純化方法Purify it via its dichromate complex (m 149o, after five recrystallisations from water). [Cumper et al. J Chem Soc 1176 1962, Beilstein 20 III/IV 3497, 20/7 V 402.]

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関連反応

23 件

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