トブラマイシンスルファート
Tobramycin Sulfate
基本情報
- CAS
49842-07-1- 標準SMILES
NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O.NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O- InChIKey
NZKFUBQRAWPZJP-BXKLGIMVSA-N- 分子式
- C36H84N10O38S5
- 平均分子量
- 1,425.4 g/mol
- 単同位体質量
- 1,424.3551541
概要
Tobramycin Sulfate can cause developmental toxicity according to state or federal government labeling requirements.
名称と識別子
- 優先名称
- Tobramycin Sulfate
- IUPAC
- bis((2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol);sulfuric acid
- 現地名
- トブラマイシンスルファート
- 英語名
- Tobramycin sulphate
- 分子式
- C18H39N5O13S
- 分子量
- 565.59
名称と別名
TOBRAMYCIN SULFATEGernebcin49842-07-1NebicinaObracinNebcinTobraTobradistinHJT0RXD7JKTobramycin sulfate (2:5)DTXSID50964441TOBRAMYCIN SULFATE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER
名称をさらに表示
トブラマイシン・硫酸塩トブラマイシンスルファートTOBRAMYCIN SULPHATEobracinetenemicinTOBRAMYCIN SLIPHATETOBRAMYCIN SULPHATETobraMycin Sulfate API1-epitobramycinsulfateTOBRAMYCIN SULFATE SALTTobramycin Sulfate IHRS
D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1.fwdarw.6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1.fwdarw.4))-2-deoxy-, sulfate (2:5) (salt)Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-, D-, sulfate (salt)Sulfate, TobramycinNSC180514RefChem:56136DTXCID701511588TOBRAMYCIN SULFATE (PHARMACY BULK)256-499-2
データベース識別子
- CAS
49842-07-1- PubChem CID
- 11954252
- DTXSID
DTXSID50964441- ChEMBL
CHEMBL3989564- UNII
- HJT0RXD7JK
- EC Number
- 256-499-2
物性
構造計算による物性
- 極性表面積
- 951 Ų
- 水素結合供与体数
- 30
- 水素結合受容体数
- 48
- 回転可能結合数
- 12
- 重原子数
- 89
- 形式電荷
- 0
- 複雑度
- 690
実験および物理化学的性質
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antibacterial Agents; Aminoglycosides
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
- 貯蔵温度
- 2 · 2-8°C
- 溶解性
- Methanol (Slightly), Water (Sparingly)
- 外見
- Powder
- 色
- White to off-white
- 水溶解度
- 水に溶けます (50 mg/ml)。
- 安定性
- Hygroscopic
- InChIKey
- ZEUUPKVZFKBXPW-SYOBZNKXNA-N
- SMILES
- OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
- CAS データベース
- 49842 · 49842-07-1
- EPAの化学物質情報
- Tobramycin sulfate (49842-07-1)
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H312 (98.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]
P203, P261, P271, P280, P302+P352, P304+P340, P317, P318, P321, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 91 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory InformationHazard Traits - Developmental Toxicity
Other Safety InformationIMAP assessments - D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.6)-O-[2,6-diamino-2,3,6-trideoxy-.alpha.-D-ribo-hexopyranosyl-(1.fwdarw.4)]-2-deoxy-, sulfate (salt): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (98.9%)
毒性情報
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
安全データ
- wgk
- 3
- hs_code
- 2941900000
- risk_code
- 61-20/21/22
- hazard_code
- T
- safety_code
- 53-22-36/37/39-45
- Hazard Classifications
- Acute Tox. 4 DermalAcute Tox. 4 InhalationRepr. 1B
- ストレージクラス
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
化学と産業
薬理情報
FDA Pharmacological Classification
TOBRAMYCIN SULFATE
Aminoglycosides [CS]; Aminoglycoside Antibacterial [EPC]
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
応用分野
使用Tobramycin sulfate is used as an antibiotic which is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections1. Product T1783 has been used to study antibiotic resistance2.
上流・下流製品情報
上流原料
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