ギダゼパム
Gidazepam
基本情報
- CAS
129186-29-4- 標準SMILES
NNC(=O)CN1C(=O)CN=C(c2ccccc2)c2cc(Br)ccc21- InChIKey
XLGCMZLSEXRBSG-UHFFFAOYSA-N- 分子式
- C17H15BrN4O2
- 平均分子量
- 387.2 g/mol
- 単同位体質量
- 386.03784
概要
prodrug for 7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepine-2-one
名称と識別子
- 優先名称
- Gidazepam
- IUPAC
- 2-(7-bromo-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl)acetohydrazide
- 現地名
- ギダゼパム
- 英語名
- gidazepam
- 分子式
- C17H15BrN4O2
- 分子量
- 387.236
名称と別名
gidazepam129186-29-4XMJ87I93Y9(1-Hydrazinocarbonyl)-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepine-2-oneDTXSID00156091RefChem:143176DTXCID00785822-(7-bromo-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl)acetohydrazideUNII-XMJ87I93Y92-(7-bromo-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)acetohydrazideGidasepam;Hidazepam; Hydazepam1H-1,4-Benzodiazepine-1-acetic acid, 7-bromo-2,3-dihydro-2-oxo-5-phenyl-, hydrazide
名称をさらに表示
2-(7-ブロモ-2-オキソ-5-フェニル-2,3-ジヒドロ-1H-1,4-ベンゾジアゼピン-1-イル)アセトヒドラジドギダゼパム5-フェニル-7-ブロモ-2-オキソ-2,3-ジヒドロ-1H-1,4-ベンゾジアゼピン-1-アセトヒドラジドHidazepamGidasepam7-Bromo-2,3-Dihydro-2-Oxo-5-Phenyl-1H-1,4-Benzodiazepine-1-Aceticacid Hydrazide1H-1,4-Benzodiazepine-1-aceticacid, 7-bromo-2,3-dihydro-2-oxo-5-phenyl-, hydrazide
MLS001012266ZINC1544309SMR000425069(7-Bromo-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-acetic acid hydrazideHydazepamChemDiv1_027291GIDAZEPAM [WHO-DD]Oprea1_121006
データベース識別子
- CAS
129186-29-4- PubChem CID
- 121919
- DTXSID
DTXSID00156091- ChEMBL
CHEMBL1565882- UNII
- XMJ87I93Y9
- Nikkaji
- J543.825J
物性
構造計算による物性
- XLogP
- 1.7
- 極性表面積
- 87.8 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 4
- 回転可能結合数
- 3
- 重原子数
- 24
- 形式電荷
- 0
- 複雑度
- 519
物理化学的性質
- 沸点
- 675.6 · 675.6±55.0 °C(Predicted)
- 比重(密度)
- 1.58 · 1.58±0.1 g/cm3(Predicted)
- 貯蔵温度
- -20 °C · Store at -20°C
- 溶解性
- Soluble in DMSO
- 酸解離定数(Pka)
- 12.37 · 12.37±0.37(Predicted)
- 外見
- Solid
- 色
- White to off-white
- InChI
- InChI=1S/C17H15BrN4O2/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)20-9-16(24)22(14)10-15(23)21-19/h1-8H,9-10,19H2,(H,21,23)
- InChIKey
- XLGCMZLSEXRBSG-UHFFFAOYSA-N
- SMILES
- N1(CC(NN)=O)C2=CC=C(Br)C=C2C(C2=CC=CC=C2)=NCC1=O
化学と産業
薬理情報
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drugs used to prevent SEIZURES or reduce their severity.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
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