イソフタロニトリル

0.39

0.8

4.42 (NIOSH, 2024) - Denser than water; will sink

1.3 g/cm³

4.42

4.42

NEEDLES FROM ALCOHOL

Needle-like, colorless to white, crystalline, flaky solid.

Slight (NIOSH, 2024)

SLIGHTLY SOL IN HOT WATER, VERY SOL IN HOT ALCOHOL, ETHER, BENZENE, CHLOROFORM, INSOL IN PETROLEUM ETHER

Solubility in water, g/100ml at 20 °C: 0.07

Slight

Sublimes (NIOSH, 2024)

Sublimes

Sublimes

324 °F (Sublimes) (NIOSH, 2024)

162 °C

324 °F (sublimes)

324 °F (Sublimes)

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P270, P271, P301+P317, P304+P340, P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 80 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

Chemical: 1,3-Benzenedicarbonitrile

1,3-Benzenedicarbonitrile is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Benzenedicarbonitrile are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 08-04-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/30720

m-Phthalodinitrile: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.

An oral dose of 250 mg/kg causes convulsions and death in rabbits. Unlike the aliphatic nitriles, aromatic nitriles such as m-phthalodinitrile do not liberate cyanide in the body. No reports of adverse effects were found in a review of 15 years of industrial experience with this chemical. [ACGIH] An eye irritant; [ICSC] See NITRILES.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Use water spray, powder, foam, carbon dioxide. In case of fire: keep cylinder cool by spraying with water.

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Refer for medical attention .

Excerpt from NIOSH Pocket Guide for m-Phthalodinitrile:

(General first aid procedures)

The worker should wash daily at the end of each work shift.

Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.

Cough.

Redness.

Diarrhoea.

headache, nausea, confusion; In Animals: irritation eyes, skin

DERMAL TOXICITY STUDIES IN RABBITS WERE CARRIED FOR 21 DAYS /USING/ DERMAL APPLICATIONS OF 0.5, 1.0 & 2.0 G/KG...WHICH WAS LEFT IN CONTACT WITH INTACT & ALSO ABRADED SKIN FOR 6 HR/DAY, 5 DAYS/WK, FOR 3 CONSECUTIVE WK. OCCASIONAL SLIGHT SKIN REACTIONS OBSERVED. SOME CHANGES...IN ORGAN SIZE...AT THE TWO HIGH DOSE LEVELS & SOME LOSS OF BODY WT IN FEMALES AT HIGHEST DOSAGE.

NO REPORTS OF ADVERSE EFFECTS WERE REPORTED IN 15-YR REVIEW OF INDUSTRIAL EXPERIENCE WITH M-PHTHALODINITRILE. THE PROBABLE REASON FOR LACK OF SYSTEMIC EFFECTS OF IPN IS THAT AROMATIC, UNLIKE ALIPHATIC, NITRILES DO NOT LIBERATE CYANIDE IN THE BODY.

Used in the production of polyurethane coatings and tetrachloroisophthalonitrile; [ACGIH]

CHEM INT FOR AMINES-EG, M-XYLENEDIAMINE

(1979) No Data

(1981) No Data

(1979) No Data

(1981) No Data

2022: 81,000 lb

(1979) PROBABLY GREATER THAN 2.27X10+6 GRAMS

(1980) PROBABLY GREATER THAN 2.27X10+6 GRAMS

All Other Basic Organic Chemical Manufacturing

1,3-Benzenedicarbonitrile: ACTIVE

1,3-DICYANOBENZENE WAS AMONG COMPOUNDS PREPARED AND TESTED FOR ANTIINFLAMMATORY ACTIVITY.

THE RECOMMENDED MAXIMUM CONCENTRATION OF ISOPHTHALONITRILE IN WATER SUPPLIES IS 5 MG/L. THIS CONCN IS BELOW THE THRESHOLD FOR ODOR DETECTION (9 MG/L), WILL NOT AFFECT THE SELF-PURIFICATION OF THE STREAM, AND CORRESPONDS TO THE DOSE, 0.25 MG/KG, OBSERVED AS NON-TOXIC.