りんご酸アルモトリプタン
りんご酸アルモトリプタン · Axert · Almogran · PNU 180638 · PNU-180638 · Almotriptan · LAS-31416 Malate · 1-[[[3-[2-(dimeth
識別子と物理属性
| CAS No. | 181183-52-8 |
|---|---|
| 分子式 | C21H31N3O7S |
| 平均分子量 | 469.56 g/mol |
| 単同位体質量 | 469.18827133 g/mol |
| SMILES | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N3CCCC3)cc12.O=C(O)CC(O)C(=O)O |
| InChIKey | QHATUKWEVNMHRY-UHFFFAOYSA-N |
| PubChem CID | 123607 |
| ChEMBL | CHEMBL1200521 |
| ChEBI | CHEBI:53781 |
| EC No. | 815-382-1 |
| DTXSID | DTXSID1044225 |
| 現地名 | りんご酸アルモトリプタン |
化学・物理的性質
| 融点 | 170-172°C |
|---|---|
| 貯蔵条件 | 2-8°C |
| 溶解度 | 塩基性アルコール（微量）、DMSO（微量）、メタノール（微量、加熱）H2O: 10mg/mL, clear |
| 外観・状態 | 粉 |
| 色 | 白からベージュ |
| InChIKey | QHATUKWEVNMHRY-UHFFFAOYSA-N |
| SMILES | [S](=O)(=O)(N3CCCC3)Cc1cc2c([nH]cc2CCN(C)C)cc1.OC(CC(=O)O)C(=O)O |
化学的特性
Pale Yellow Solid
安全性と法規制
| 水環境危害等級（WGK） | WGK 3 |
|---|---|
| 税関コード | 2935904000 |
| 貯蔵分類 | 11 - Combustible Solids |
用途
説明
Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay). It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate. Formulations containing almotriptan have been used in the treatment of migraine headaches.
使用
Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.
一般的な説明
Almotriptan, marketed in 2000, has the highest oralbioavailability among all triptans. It is metabolizedby both MAO-A and CYP3A4, thus has a more favorableside effects profile when compared with sumatriptan.However, it is only available in a 12.5 mg tablet form.