塩基性フクシン

1. ...COMPETENT ENGINEERING... 2. ...ADEQUATE VENTILATION; 3. DAILY CHANGES OF FRESHLY LAUNDERED CLOTHING...& SHOWER BATH... @ END OF...WORK PERIOD; 4. ...MEDICAL DEPT FOR INSPECTION @ END OF...SHIFT; 5. INDIVIDUALS SHOWING GROSS EVIDENCE OF CYANOSIS...KEPT UNDER OBSERVATION. /AROMATIC AMINO COMPD/

6. WORKMEN SHOULD NEVER BE PERMITTED TO ENTER A VESSEL... UNTIL DEGREE OF ATMOSPHERIC CONCN HAS BEEN QUANT EST BY PLANT HYGIENIST; 7. ... COMPLETE PHYSICAL EXAM INCL HEMOGLOBIN DETERMINATIONS, RED, WHITE, & DIFFERENTIAL COUNTS, & COMPLETE URINALYSIS, EVERY 6 MO OR OFTENER. /AROMATIC AMINO COMPD/

OF 85 MEN KNOWN TO HAVE BEEN ENGAGED IN MANUFACTURING MAGENTA...THERE WERE 5 CASES OF BLADDER CANCER. THREE OF THESE WERE RECORDED AS DYING OF BLADDER CANCER, WHEREAS ONLY 0.13 CASES WOULD HAVE BEEN EXPECTED (RELATIVE RISK= 23.0; P LESS THAN 0.005). /MAGENTA/

...INJECTED 10 MG PARA-MAGENTA AS 1% SOLN SC WEEKLY...INTO 20 BD III RATS. FIRST LOCAL SARCOMA...@ 300 DAYS, AFTER TOTAL DOSE OF 370 MG OF DYE. TOTAL OF 7 SARCOMAS...IN 12 RATS SURVIVING AFTER APPEARANCE OF FIRST TUMOR, COMPARED TO SPONTANEOUS INCIDENCE OF SARCOMAS IN THESE RATS OF LESS THAN 5%.

...12 MG MAGENTA IN ARACHIS OIL PER WK WAS GIVEN TO 60 STOCK MICE BY GASTRIC INSTILLATION FOR 52 WK (TOTAL DOSE, 624 MG). DYE WAS FOUND TO HAVE STAINED TISSUES @ AUTOPSY...4 LYMPHOMAS & 1 HEPATOMA IN 21 TEST ANIMALS, & 5 LYMPHOMAS WERE FOUND IN 18 CONTROLS... /MAGENTA/

...IT IS NOT POSSIBLE TO INDICATE WHETHER INDUSTRIAL BLADDER CANCER FOUND IN MAGENTA WORKERS IS ATTRIBUTABLE TO EXPOSURE TO MAGENTA ITSELF, OR TO ONE OR MORE OF ITS ASSOCIATED INTERMEDIATES & IMPURITIES. /MAGENTA/

...SHOWED THAT THERE WAS HIGHLY SIGNIFICANT RISK OF CONTRACTING BLADDER CANCER AMONG MEN ENGAGED IN MANUFACTURING, BUT NOT IN PURIFYING OR USING, MAGENTA. /MAGENTA/

THE MFR OF MAGENTA HAS CARRIED A CARCINOGENIC SUBSTANCES REGULATIONS 1967, BUT THERE APPEARS TO BE NO FIRM EVIDENCE THAT MAGENTA ITSELF IS CARCINOGENIC. /MAGENTA/

IN TREATMENT OF EYES CONTAMINATED WITH CATIONIC DYES, FIRST AID MEASURES... INCLUDES COPIOUS IRRIGATION, MECHANICAL REMOVAL OF PARTICLES, & IN CASE OF IMBEDDED COLORED PENCIL MAY NECESSITATE SURGICAL EXPLORATION & CAREFUL REMOVAL OF PARTICLES. /CATIONIC DYES/

CATIONIC DYES ARE WELL KNOWN TO BIND TO NUCLEIC ACIDS. /CATIONIC DYES/

CATIONIC DYES APPEAR TO HAVE SPECIAL ATTRIBUTE OF NITROGEN ATOM WHICH IS PART OF RESONANT SYSTEM RESPONSIBLE FOR COLOR, & WHICH APPEARS TO BE ASSOC WITH PROPENSITY TO VERY STRONG BINDING TO CARBOXYL GROUPS OF CORNEAL MUCOPROTEINS. /CATIONIC DYES/

Used as dye for oils, fats, waxes (especially polishes), carbon papers, and ball point pen inks; [HSDB]

Pulp and Paper Processing [Category: Industry]

AS DYE OR DYE INTERMEDIATE, COLORING TEXTILE FIBERS, FABRICS, PAPER PRODUCTS, TO DYE COTTON, WOOL, JUTE FIBERS, CHINA CLAY PRODUCTS, LEATHER; IN PRINTING INKS, AS A FILTER DYE IN PHOTOGRAPHY; BIOLOGICAL STAIN; LAB REAGENT, IN THIN-LAYER CHROMATOGRAPHY /MAGENTA/

DYE FOR OILS, FATS, WAXES (ESPECIALLY FOR POLISHES); DYE FOR CARBON PAPERS AND BALL POINT PEN INKS

MEDICATION

(1972) No Data

(1975) No Data

(1972) No Data

(1975) No Data

(1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS

(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS

OXIDATION OF A MIXTURE OF ANILINE, O(AND P)-TOLUIDINE & THEIR HYDROCHLORIDES WITH NITROBENZENE, OR A MIXTURE OF NITROBENZENE & O-NITROTOLUENE, IN PRESENCE OF FERROUS CHLORIDE, FERROUS OXIDE & ZINC CHLORIDE, FOLLOWED BY NEUTRALIZATION TO THE FREE BASE

A SYNTHETIC ROSANILINE DYESTUFF, A MIXTURE OF ROSANILINE & PARAROSANILINE HYDROCHLORIDES. ... GRADE NF.

MAGENTA, AS COMMERCIAL MATERIAL, IS MIXTURE OF...MAGENTA I, PARA-MAGENTA, & SMALL AMT OF MAGENTA II. MAGENTA...AVAILABLE IN US AS BASIC FUCHSIN NF... /CONTAINING/ A MAX LIMIT OF 8 PPM OF ARSENIC & 30 PPM OF LEAD (AMERICAN PHARMACEUTICAL ASSOC, 1970). /MAGENTA/