3-ヒドロキシフェナゼパム
3-hydroxyphenazepam
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基本情報
- CAS
70030-11-4- 標準SMILES
O=C1Nc2ccc(Br)cc2C(c2ccccc2Cl)=NC1O- InChIKey
KRJKJUWAZOWXNV-UHFFFAOYSA-N- 分子式
- C15H10BrClN2O2
- 平均分子量
- 365.61 g/mol
名称と識別子
- 優先名称
- 3-hydroxyphenazepam
- 現地名
- 3-ヒドロキシフェナゼパム
- 英語名
- 3-hydroxyphenazepam
- 分子式
- C15H10BrClN2O2
- 分子量
- 365.61
名称と別名
3-ヒドロキシフェナゼパム7-ブロモ-5-(2-クロロフェニル)-3-ヒドロキシ-2,3-ジヒドロ-1H-1,4-ベンゾジアゼピン-2-オン5-(2-クロロフェニル)-3-ヒドロキシ-7-ブロモ-1H-1,4-ベンゾジアゼピン-2(3H)-オン3-hydroxyphenazepam3-Hydroxyphenazepam CAS NO.70030-11-43-Hydroxyphenazepam 1.0 mg/ml in Methanol7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one2H-1,4-Benzodiazepin-2-one, 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-
データベース識別子
- CAS
70030-11-4- PubChem CID
- 125820
- ChEMBL
CHEMBL1449427- UNII
- 1KJ8MP77JK
- Nikkaji
- J1.074.642F
物性
物理化学的性質
- 沸点
- 544.5 · 544.5±50.0 °C(Predicted)
- 比重(密度)
- 1.7 · 1.70±0.1 g/cm3(Predicted)
- 貯蔵温度
- refrigerate for prolonged storage
- 溶解性
- 15 mg/ml; · DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.2 mg/ml
- 外見
- A neat solid
- 酸解離定数(Pka)
- 10.8 · 10.80±0.70(Predicted)
- 色
- 白い粉
化学と産業
応用分野
説明3-Hydroxyphenazepam is an active metabolite of the novel psychoactive benzodiazepine phenazepam, which emerged in online drug markets in late 2011. Despite being a controlled substance in Europe, North America, and many countries in Asia, phenazepam has been encountered in the form of LSD mimic blotters and as counterfeit diazepam. This certified Snap-N-Spike(R) solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.
使用3-Hydroxyphenazepam, a metabolite of phenazepam, is also a GABAA receptor agonist. It has diminished myorelaxant properties, but is about equivalent in most other regards.Like other benzodiazepines, 3-hydroxyphenazepam behaves as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor with an EC50 value of 10.3 nM. 3-hydroxyphenazepam is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety.
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