化工社化工社 化学情報印刷レポート · 研究参考用
7-アミノ-4-メチルクマリン-3-酢酸
7-アミノ-4-メチルクマリン-3-酢酸 · 7-アミノ-4-メチル-3-クマリニル酢酸 · AMCA-H · AMCA blue · AMCA acid · AMCA (coumarin) · AMCA Free Acid (Blue) · 2H-1-Benzopyran-3-acetic acid
識別子と物理属性
| CAS No. | 106562-32-7 |
|---|---|
| 分子式 | C12H11NO4 |
| 平均分子量 | 233.22 g/mol |
| 単同位体質量 | 233.06880783 g/mol |
| SMILES | Cc1c(CC(=O)O)c(=O)oc2cc(N)ccc12 |
| InChIKey | QEQDLKUMPUDNPG-UHFFFAOYSA-N |
| PubChem CID | 129367 |
| EC No. | 635-163-2 |
| DTXSID | DTXSID20147648 |
| 現地名 | 7-アミノ-4-メチルクマリン-3-酢酸 |
化学・物理的性質
| XLogP | 0.6 |
|---|---|
| 極性表面積 | 89.6 |
| 水素結合供与体数 | 2 |
| 水素結合受容体数 | 5 |
| 回転可能結合数 | 2 |
| 重原子数 | 17 |
| 形式電荷 | 0 |
| 複雑度 | 388 |
| 物質分類 | Dyes -> Coumarin Dyes |
| Physical Description | Light brown powder[Sigma-Aldrich MSDS] |
| 沸点 | 512.2±50.0 °C(Predicted) |
| 密度 | 1.391±0.06 g/cm3 (20 ºC 760 Torr) |
| 貯蔵条件 | Keep in dark place,Sealed in dry,Room Temperature |
| 溶解度 | DMF：可溶 |
| 外観・状態 | powder to crystal |
| pKa（酸解離定数） | 3.80±0.10(Predicted) |
| 色 | Light yellow to Brown |
| BRN | 7927205 |
| InChI | InChI=1S/C12H11NO4/c1-6-8-3-2-7(13)4-10(8)17-12(16)9(6)5-11(14)15/h2-4H,5,13H2,1H3,(H,14,15) |
| InChIKey | QEQDLKUMPUDNPG-UHFFFAOYSA-N |
| SMILES | C1(=O)OC2=CC(N)=CC=C2C(C)=C1CC(O)=O |
安全性と法規制
| GHS 分類 | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 有害性の概要 | An irritant[Sigma-Aldrich MSDS] See Coumarin 120. |
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| 水環境危害等級（WGK） | 3 |
| 税関コード | 29322090 |
| 危険文句（R） | 36/37/38 |
| 危険表示 | Xi |
| 安全措置（S） | 26-36 |
| 危険等級 | Eye Irrit. 2Skin Irrit. 2STOT SE 3 |
| 貯蔵分類 | 11 - Combustible Solids |
用途
用途
有機合成原料。
説明
AMCA is fluorescent protein labeling agent. It contains an N-hydroxysuccinimide ester that reacts with lysine residues to form photostable amide links. Upon activation with UV light, AMCA displays emission maxima of 400-460 nm. It has commonly been used in multiplex immunophenotyping applications.
使用
7-AMINO-4-METHYL-3-COUMARINYLACETIC ACID is a blue fluorescent dye. Its desirable properties include a relatively large Stoke's shift and resistance to photobleaching. 7-AMINO-4-METHYL-3-COUMARINYLACETIC ACID is used as contrasting probes for double and triple labeling in im