ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /化合物

ジメチルすずジクロリド

Dimethyltin dichloride

HCID 12955
ノートを作成反応を作成見積依頼を出す
印刷プレビュー
基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
部分構造検索類似構造を探す

基本情報

CAS
753-73-1
標準SMILES
[CH3][Sn]([CH3])([Cl])[Cl]
InChIKey
PKKGKUDPKRTKLJ-UHFFFAOYSA-L
分子式
C2H6Cl2Sn
平均分子量
219.68 g/mol
単同位体質量
219.886858

概要

Dimethyltin dichloride is an organotin compound. Tin is a chemical element with the symbol Sn and atomic number 50. It is a natural component of the earth's crust and is obtained chiefly from the mineral cassiterite, where it occurs as tin dioxide. (L307, L309)

名称と識別子

優先名称
Dimethyltin dichloride
IUPAC
dichloro(dimethyl)stannane
現地名
ジメチルすずジクロリド
英語名
Dimethyltin dichloride
分子式
C2H6Cl2Sn
分子量
219.68

名称と別名

Dimethyltin dichloride753-73-1DichlorodimethyltinDichlorodimethylstannaneDimethyldichlorotinSTANNANE, DICHLORODIMETHYL-DimethyltindichlorideDimethyldichlorostannaneCotin 210Dichlorid dimethylcinicityDimethylzinndichlorideDTXSID5027304
名称をさらに表示
ジメチルすずジクロリドジメチルジクロロすず(IV)ジクロロジメチルスタンナンジクロロジメチルすず(IV)ジメチルジクロロスタンナンジメチルすず(IV)ジクロリド二塩化ジメチルすずジクロロジメチルスズ酸塩ジメチルジクロルすず二塩化ジメチルすず()ジクロロジメチルスズ酸ジクロロジメチルスズ二塩化ジメチルスズ(Ⅳ)二塩化ジメチルすず(IV)二塩化ジメチルすず, min. 95%3-エチル-2-[3-(3-エチル-2,3-ジヒドロ-1,3-ベンゾチアゾール-2-イリデン)-2-メチルプロパ-1-エン-1-イル]-1,3-ベンゾチアゾール-3-イウム3,3′-ジエチル-9-メチルチアカルボシアニン2-[3-(3-エチル-2,3-ジヒドロベンゾチアゾール-2-イリデン)-2-メチル-1-プロペニル]-3-エチルベンゾチアゾール-3-イウム二塩化ジメチルすず標準品(CH3)2SnCl2DMTC50%SKL1117tin dichLTwo MethyltinDiMethyltin-di
DMTC7K42FNK7A0NSC-55159DTXCID907304RefChem:588622212-039-2dichloro(dimethyl)stannaneTin, dimethyl-, dichloride

データベース識別子

CAS
753-73-1
PubChem CID
12955
DTXSID
DTXSID5027304
UNII
7K42FNK7A0
EC Number
212-039-2

物性

構造計算による物性

極性表面積
0 Ų
水素結合供与体数
0
水素結合受容体数
0
回転可能結合数
0
重原子数
5
形式電荷
0
複雑度
30.6

実験および物理化学的性質

Chemical ClassesMetals -> Tin Compounds, Organic
Vapor Pressure0.2 [mmHg]
Physical Description · 2 件

Wet Solid; Liquid

Produced as a solid or aqueous solution; [ECHA - Proposal for Harmonised Classification and Labelling] White crystalline solid; [Alfa Aesar MSDS]

物理化学的性質

融点
101 · 101-106 °C (lit.)
沸点
188 · 188-190°C
比重(密度)
1 · 1,397 g/cm3
蒸気圧
4 Pa · 4Pa at 20℃
闪点
185 · 185-190°C
貯蔵温度
2 · 2-8°C
溶解性
0.1 g/mL、透明 · メタノール: 0.1 g/mL、透明
外見
結晶
色
白い
比重
1.397 · 1.397
水溶解度
20 g/L、20℃)。他の溶媒への溶解度 · 水に溶けにくい(20g/L、20℃)。他の溶媒への溶解度 (メタノール中 0.1 g/ml)。
BRN
3660508 · 3660508
安定性
Hygroscopic, Moisture sensitive
InChI

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 6 件

Danger

H301: Toxic if swallowed [Danger Acute toxicity, oral]

P203, P260, P262, P264, P270, P271, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P318, P319, P320, P321, P330, P361+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P203, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P320, P321, P330, P361+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

危険有害性情報

Regulatory Information · 4 件

Chemical: Stannane, dichlorodimethyl-

Stannane, dichlorodimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Stannane, dichlorodimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Dimethyltin dichloride (EC: 212-039-2)

Dimethyltin dichloride: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Stannane, dichlorodimethyl-: Human health tier II assessment
Hazards Summary · 1 件

Produced as a mixture with monomethyltin trichloride (CAS# 993-16-8); Teratogenicity observed in rats administered 20 mg/kg on days 7-17 of gestation; [Shepard's Catalog of Teratogenic Agents] Corrosive to rabbit skin; The nervous system is the target of toxicity in 90-day oral studies of rats, with neuropathological lesions observed in one study at doses as low as 25 ppm (1.6/2.2 mg/kg/day); One oral study of rats produced serious teratogenic effects not considered as related to maternal toxicity; Another study of rats demonstrated no teratogenicity; Possible developmental neurotoxicity observed in other studies of rats; [ECHA - Proposal for Harmonised Classification and Labelling] Reacts with water; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion, inhalation, and skin absorption; [Alfa Aesar MSDS] See Trimethyltin chloride and Di-n-butyltin dichloride. See Tin, organic compounds.

化学と産業

薬理情報

Metabolism/Metabolites · 1 件

Though tin metal is very poorly absorbed, tin compounds may be absorbed via oral, inhalation, or dermal routes, with organotin compounds being much more readily absorbed than inorganic tin compounds. Tin may enter the bloodstream and bind to hemoglobin, where it is distributed and accumulates mainly in the kidney, liver, lung, and bone. Organotin compounds may undergo dealkylation, hydroxylation, dearylation, and oxidation catalyzed by cytochrome P-450 enzymes in the liver. The alkyl products of dealkylation are conjugated with glutathione and further metabolized to mercapturic acid derivatives. Tin and its metabolites are excreted mainly in the urine and feces. (L308)

用途と製造

Uses · 2 件

Used for stabilizing PVC potable water piping, making abrasion resistant glass containers, and as a catalyst for curing electrocoated paints; [Shepard's Catalog of Teratogenic Agents] Used to make other organotin compounds and for glass coating; [OECD: SIDS Dossier]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

U.S. Production2023: 1,000,000 - <8,500,000 lb
Industry UsesIntermediate
General Manufacturing Information · 2 件

All Other Basic Organic Chemical Manufacturing

Stannane, dichlorodimethyl-: ACTIVE

応用分野

用途有機合成原料、塩化ビニル添加剤、ガラス工業。

使用Used as a pharmaceutical intermediate. It is employed as a coating, plastic and rubber auxilliary agent. Used as methyl Tin stabilizer intermediates, catalysts for esterification reaction, raw material for glass coating.

上流・下流製品情報

下流製品

関連反応

14 件
反応記録を作成
HRID 86193 の反応式
HRID 86193反応物としてTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
HRID 323912 の反応式
HRID 323912反応物としてuspto-grants-2001_04
HRID 461427 の反応式
HRID 461427反応物としてuspto-grants-1977_12
HRID 613794 の反応式
HRID 613794反応物としてuspto-grants-1999_12
HRID 908518 の反応式
HRID 908518反応物としてuspto-grants-2011_09
HRID 1086911 の反応式
HRID 1086911反応物としてuspto-grants-1991_07
HRID 1130162 の反応式
HRID 1130162反応物としてTraining data from https://doi.org/10.1039/C8SC04228D (7/10)
HRID 1440432 の反応式
HRID 1440432反応物としてuspto-grants-1996_03
1 / 2 ページ

化合物ノート

読み込み中…

このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
その他の操作
ノートを作成反応を作成見積依頼を出す
1S/2CH3.2ClH.Sn/h2*1H3;2*1H;/q;;;;+2/p-2
InChIKey
PKKGKUDPKRTKLJ-UHFFFAOYSA-L
SMILES
C[Sn](C)(Cl)Cl
LogP
-2.18 at · -2.18 at 22℃
CAS データベース
753 · 753-73-1(CAS DataBase Reference)
EPAの化学物質情報
Stannane, dichlorodimethyl- (753-73-1)

化学的性質

化学的特性white crystalline powder

Hazard Classes and Categories · 3 件

Acute Tox. 3 (100%)

Acute toxicity (ingestion) - category 3

Repr. 2

安全と保護具

Exposure Control and Personal Protection0.02 [mg/m3], as Sn[German Research Foundation (DFG)]
Threshold Limit Values (TLV)0.2 [mg/m3], as Sn
Permissible Exposure Limit (PEL)0.1 [mg/m3], as Sn
Immediately Dangerous to Life or Health (IDLH)25.0 [mg/m3], as Sn

毒性情報

Health EffectsBreathing or swallowing, or skin contact with organotins, can interfere with the way the brain and nervous system work, causing death in severe cases. Organic tin compounds may also damage the immune and reproductive system. (L307, L308)
Adverse EffectsNeurotoxin - Other CNS neurotoxin
Exposure RoutesOral (L308) ; inhalation (L308) ; dermal (L308)
Toxicity Summary · 1 件

Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local release of pro-inflammatory cytokines, tumor necrosis factor-_, and/or interleukins. They may also induce apoptosis by direct action on neuronal cells. Organotin compounds stimulate the neuronal release of and/or decrease of neuronal cell uptake of neurotransmitters in brain tissue, including aspartate, GABA, glutamate, norepinephrine, and serotonin. This may be either a contributing factor to or result of the neuronal cell loss. The immunotoxic effects of organotins are characterized by thymic atrophy caused by the suppression of proliferation of immature thymocytes and apoptosis of mature thymocytes. Organotin compounds are believed to exert these effects by suppressing DNA and protein synthesis, inducing the expression of genes involved in apoptosis (such as nur77), and disrupting the regulation of intracellular calcium levels, giving rise to the uncontrolled production of reactive oxygen species, release of cytochrome c to the cytosol, and the proteolytic and nucleolytic cascade of apoptosis. The suppression of proliferation of immature thymocytes further results in the suppression of T-cell-mediated immune responses. Organotins are also endocrine disruptors and are believed to contribute to obesity by inappropriate receptor activation, leading to adipocyte differentiation. Inorganic tin triggers eryptosis, contributing to tin-induced anemia. (L308, A182, A184)

Signs and SymptomsInorganic or organic tin compounds placed on the skin or in the eyes can produce skin and eye irritation. (L308)
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Toxicity DataLC50 (rat) = 115 mg/m3/4hr

安全データ

wgk
3
tsca
TSCA listed
rtecs
WH7245000
ridadr
UN 2923 8/PG 2
PRTR法
第一種指定化学物質
hs_code
29319090
risk_code
23/24/25-36/37/38-34
化審法
(2)-2247
安衛法
57,57-2
hazard_code
T
safety_code
26-36/37/39-45
hazard_class
6.1
packing_group
II
環境リスク評価
ジメチル二塩化スズ(DMTC)(753-73-1)
Hazard Classifications
Acute Tox. 2 InhalationAcute Tox. 3 DermalAcute Tox. 3 OralAquatic Chronic 3Eye Dam. 1Repr. 2Skin Corr. 1BSTOT RE 1
ストレージクラス
6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
トリメチルすずクロリドビス(ラウロイルオキシ)ジメチルスタンナン