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Phenformin Hydrochloride

HCID 13266
ノート反応
基本情報概要名称と識別子物性安全と法規制関連反応化合物ノート
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基本情報

CAS
3493-37-6
標準SMILES
Cl.NC(N)=NC(N)=NCCc1ccccc1
InChIKey
YSUCWSWKRIOILX-UHFFFAOYSA-N
分子式
C10H15N5.ClH
平均分子量
241.72 g/mol
単同位体質量
241.1094232

概要

Phenformin hydrochloride appears as white solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis.

名称と識別子

優先名称
Phenformin Hydrochloride
IUPAC
1-(diaminomethylidene)-2-(2-phenylethyl)guanidine;hydrochloride

名称と別名

PHENFORMIN HYDROCHLORIDEMeltrol-50DebeiPhenformin, hydrochloridePhenformin HCl No. 9113CCRIS 4857DTXSID0021121Phenoformine hydrochlorideEINECS 212-637-3NSC 23100NSC-231001-Fenetilbiguanide cloridrato
名称をさらに表示
UNII-91XC93EU031beta-Phenylethylbiguanide hydrochloride1-Fenetilbiguanide cloridrato [Italian]Phenformin hydrochloride [USP]Debei (TN)AI3-512711-Phenylaethylbiguanid hydrochlorid [German]91XC93EU03

データベース識別子

CAS
3493-37-6、834-28-6
PubChem CID
13266
DTXSID
DTXSID0021121
ChEMBL
CHEMBL1528839
UNII
91XC93EU03
EC Number
212-637-3

物性

構造計算による物性

極性表面積
103 Ų
水素結合供与体数
4
水素結合受容体数
1
回転可能結合数
4
重原子数
16
形式電荷
0
複雑度
236

実験および物理化学的性質

Solubility · 2 件

greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)

>36.3 [ug/mL] (The mean of the results at pH 7.4)

Melting Point347 to 352 °F (NTP, 1992)
Physical DescriptionPhenformin hydrochloride appears as white solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis.
Collision Cross Section145.7 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 4 件

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 1 notifications to the ECHA C&L Inventory.

危険有害性情報

Other Safety InformationIMAP assessments - Imidodicarbonimidic diamide, N-(2-phenylethyl)-, monohydrochloride: Human health tier I assessment
DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Symptoms of exposure to this compound include metallic taste, nausea, anorexia, vomiting, diarrhea, cramps, weight loss and weakness.
Reactive GroupAmines, Phosphines, and Pyridines
Reactivity ProfilePHENFORMIN HYDROCHLORIDE gives weakly acidic aqueous solutions. May react with strong oxidizing agents.
Air and Water ReactionsWater soluble.
Hazard Classes and CategoriesAcute Tox. 4 (100%)

安全と保護具

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

関連反応

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化合物ノート

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このページの内容基本情報概要名称と識別子物性安全と法規制関連反応化合物ノート
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

毒性情報

Carcinogen Classification · 6 件

Phenformin hydrochloride

TR-007: Bioassay of Phenformin for Possible Carcinogenicity (CASRN 114-86-3) (1977 )

03/25/77

No Evidence

No Evidence

No Evidence