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N,N-ジメチル-N'-フェニル-N'-フェニルメチル-1,2-エタンジアミン

Phenbenzamine

HCID 13751
ノート反応
基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
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基本情報

CAS
961-71-7
標準SMILES
CN(C)CCN(Cc1ccccc1)c1ccccc1
InChIKey
CHOBRHHOYQKCOU-UHFFFAOYSA-N
分子式
C17H22N2
平均分子量
254.37 g/mol
単同位体質量
254.17829871

概要

Phenbenzamine is a liquid. (NTP, 1992)

名称と識別子

優先名称
Phenbenzamine
IUPAC
N'-benzyl-N,N-dimethyl-N'-phenylethane-1,2-diamine
現地名
N,N-ジメチル-N'-フェニル-N'-フェニルメチル-1,2-エタンジアミン
英語名
Antergan
分子式
C17H22N2
分子量
254.37

名称と別名

PHENBENZAMINEAnterganLergitinBridal961-71-7DimetinaPM245PM 2452339 RPRP 2339Ethylenediamine, N-benzyl-N',N'-dimethyl-N-phenyl-733W48NG2Q
名称をさらに表示
N-ベンジル-N',N'-ジメチル-N-フェニルエチレンジアミンN'-ベンジル-N,N-ジメチル-N'-フェニルエチレンジアミンN,N-ジメチル-N'-フェニル-N'-フェニルメチル-1,2-エタンジアミンブライダルアンテルガンブリダールレルギチンフルノー化合物2339RPフェンベンザミンN-ベンジル-N-[2-(ジメチルアミノ)エチル]アニリンN′-ベンジル-N,N-ジメチル-N′-フェニルエチレンジアミンN,N-ジメチル-N′-フェニル-N′-フェニルメチル-1,2-エタンジアミンN-ベンジル-N′,N′-ジメチル-N-フェニルエチレンジアミンFourneau compound-2339RPbenzyl-(2-dimethylaminoethyl)-phenyl-amineN',N'-dimethyl-N-phenyl-N-(phenylmethyl)ethane-1,2-diamine
PM-245DTXSID3043863N,N-DIMETHYL-N'-PHENYL-N'-PHENYLMETHYL-1,2-ETHANEDIAMINERefChem:172649DTXCID1023863N-Benzyl-N',N'-dimethyl-N-phenylethylenediamineN'-benzyl-N,N-dimethyl-N'-phenylethane-1,2-diamine1,2-ETHANEDIAMINE, N1,N1-DIMETHYL-N2-PHENYL-N2-(PHENYLMETHYL)-

物性

構造計算による物性

XLogP
3.7
極性表面積
6.5 Ų
水素結合供与体数
0
水素結合受容体数
2
回転可能結合数
6
重原子数
19
形式電荷
0
複雑度
227

実験および物理化学的性質

Density1.019 (NTP, 1992) - Denser than water; will sink
Boiling Point354 to 356 °F at 7 mmHg (NTP, 1992)
Physical DescriptionPhenbenzamine is a liquid. (NTP, 1992)

物理化学的性質

沸点
387.59 °C · 387.59°C (rough estimate)
比重(密度)
1.016 · 1.0160
屈折率
1.5794 · 1.5794
色
淡黄色油
EPAの化学物質情報
Phenbenzamine (961-71-7)

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

危険有害性情報

Health HazardsACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products. (NTP, 1992)
Reactive GroupAmines, Phosphines, and Pyridines
Reactivity Profile · 1 件

PHENBENZAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Air and Water ReactionsNo rapid reaction with air. No rapid reaction with water.

安全と保護具

Fire Fighting · 1 件

This compound is not very flammable but any fire involving this compound may produce dangerous vapors. You should evacuate the area. All firefighters should wear full-body protective clothing and use self-contained breathing apparatuses. You should extinguish any fires involving this chemical with a dry chemical, carbon dioxide, foam, or halon extinguisher. (NTP, 1992)

First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: Dampen spilled material with toluene to avoid dust, then transfer material to a suitable container. Use absorbent paper dampened with toluene to pick up remaining material. Wash surfaces well with soap and water. Seal all waste in vapor-tight plastic bags for eventual disposal.

化学と産業

薬理情報

MeSH Pharmacological Classification · 5 件

Agents, usually topical, that relieve itching (pruritus).

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)

Metabolite PathwaysPhenbenzamine H1-Antihistamine Action

応用分野

来歴In 1942 phenbenzamine (Antergan), C17H22N2, was the first antihistamine to be successfully used in humans.

一般的な説明Liquid.

サプライヤー1 社

Lanospharma Laboratories Co.,Ltd13440048448 · [email protected]

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化合物ノート

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このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート

データベース識別子

CAS
961-71-7
PubChem CID
13751
DTXSID
DTXSID3043863
ChEMBL
CHEMBL157118
ChEBI
CHEBI:135041
UNII
733W48NG2Q
Nikkaji
J7.194C
Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

安全データ

毒性
LDLo ipr-rat: 120 mg/kg BJPCAL 11,1,56