3a,4,7,7a-テトラヒドロ-5-(ヒドロキシフェニル-2-ピリジニルメチル)-8-(フェニル-2-ピリジニルメチレン)-4,7-メタノ-1H-イソインドール-1,3(2H)-ジオン

(Non-Specific -- Pesticide, Solid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Landfill: Recommendable method: Incineration. Peer-review: Large amt: Incinerate in a unit with effluent gas scrubbing. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

0.35 [mg/m3]

3.8 [mg/m3]

190 [mg/m3]

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

LD50 MALLARD DUCKS ORAL GREATER THAN 3000 MG/KG, 9-10 MO OLD MALES

LD50 prairie dogs oral greater than 1000 mg/kg

IT IS EXTREMELY STABLE & PERSISTENT IN ALL BAITS & ENVIRONMENTS.

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 2000(SRC), determined from an estimated log Kow(2,SRC) and a recommended regression-derived equation(3), indicates that norbormide is expected to have slight mobility in soil(SRC). Volatilization of norbormide from moist soil surfaces is not expected (SRC) given an estimated Henry's Law constant of 2.7X10-23 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Norbormide is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 4.3X10-22 mm Hg(SRC), determined from a fragment constant method(5).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 2000(SRC), determined from an estimated log Kow(2,SRC) and a recommended regression-derived equation(3), indicates that norbormide is expected to adsorb to suspended solids and sediment in water(SRC). Norbormide is not expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 2.7X10-23 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF value of 290(3,SRC), from an estimated log Kow(2,SRC), suggests that bioconcentration in aquatic organisms is high(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), norbormide, which has an estimated vapor pressure of 4.3X10-22 mm Hg at 25 °C(2,SRC), is expected to exist entirely in the particulate phase in the ambient atmosphere. Vapor-phase norbormide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 1.7 hours(3,SRC). Particulate-phase norbormide may be physically removed from the air by wet and dry deposition(SRC).

The Koc of norbormide is estimated as approximately 2000(SRC), using an estimated log Kow of 3.5(1,SRC) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that norbormide is expected to have slight mobility in soil(SRC).

THREE ADULT MALE VOLUNTEERS RECEIVED 15 MG/KG DAILY FOR 3 DAYS WITHOUT ILL-EFFECT.

HUMANS INGESTING DOSES UP TO 300 MG SHOWED SLIGHT TRANSIENT DECR IN BODY TEMP & BLOOD PRESSURE. INTRADERMAL INJECTIONS (0.1 ML OF 0.1% SOLN) PRODUCED NO SKIN REACTIONS OR LESIONS IN MAN.

A case of contact dermatitis is described on a woman who poured over pesticide solution in order to make poisonous pesticides for rodents. The solution got on the skin of her hands, right crus and left forearm. There the signs of acute skin inflammation appeared along with the clinical picture of chronic dermatosis caused by the solution irritating characteristics.

... administered norbormide to volunteers po at doses ranging from 20 to 300 mg. No sign or symptom was produced. It was concluded that body temp and blood pressure decr slightly and temporarily following the larger doses. Actually, the largest fall in temp observed at any dose was 0.7 °C, and this occurred after doses of 20 and 80 mg, whereas the largest fall after a dose of 120 mg or more was only 0.3 °C. Systolic (but not diastolic) blood pressure possibly fell after 120 mg of norbormide and certainly fell after larger doses. The largest decr recorded were from 132/76 to 100/74 after 200 mg and from 120/80 to 96/80 after 300 mg. The lowest values were measured 1 hr after ingestion, and the values were essentially normal at 2 hr in each instance.

An estimated BCF value of 290 was calculated for norbormide(SRC), using an estimated log Kow of 3.5(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is high(SRC).

The Henry's Law constant for norbormide is estimated as 2.7X10-23 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that norbormide will be essentially nonvolatile from water surfaces(2,SRC). Norbormide's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces is not expected (SRC). Norbormide is not expected to volatilize from dry soil surfaces based on an estimated vapor pressure of 4.3X10-22 mm Hg(SRC), determined from a fragment constant method(3).

A SINGLE ORAL DOSE OF 1000 MG/KG HAD NO EFFECT ON...MONKEYS.../OR/ TURKEYS; NOR WAS IT LETHAL TO ANY OF 40 OTHER ANIMAL SPECIES TESTED.

REGURGITATION, DYSPNEA, POLYDIPSIA, SLIGHT LOSS OF BALANCE, EXCESSIVE PREENING. NO SIGNIFICANT CHANGES IN BODY WT...BY END OF 14-DAY OBSERVATION PERIOD. /MALLARD MALES 9-10 MO OLD, ACUTE ORAL STUDY/

...ACTS DIRECTLY ON SMOOTH MUSCLE OF PERIPHERAL VESSELS CAUSING THEM TO CONSTRICT IRREVERSIBLY RESULTING IN WIDESPREAD ISCHEMIA...DEATH. RECEPTOR SITES...DIFFERENT FROM.../THOSE/ FOR EPINEPHRINE. ...ASSUMED THAT NORBORMIDE RECEPTORS IN SMOOTH MUSCLE OF PERIPHERAL VESSELS EXIST UNIQUELY IN THE RAT...

IN RAT LIVER MITOCHONDRIA, MG2+-ACTIVATED ATPASE ACTIVITY WAS ENHANCED BY NORBORMIDE IN VITRO (4X10-4 MOLAR) OR IN VIVO (SINGLE ORAL DOSE OF 10 MG/KG). CA2+-ACTIVATED ATPASE WAS NOT AFFECTED. NONE OF THE ATPASES WERE AFFECTED IN MICE, FOLLOWING ORAL ADMINISTRATION OF 170 MG/KG. NORBORMIDE FEEDING HAD NO EFFECT ON THE TOTAL AND OUABAIN-SENSITIVE (NA+ + K+)-ATPASE ACTIVITIES IN THE ERYTHROCYTE MEMBRANE AND HEART MICROSOMES IN RATS. THE INCORPORATION OF INORGANIC (32)PHOSPHORUS INTO ATP, IN LIVER MITOCHONDRIA, WAS DECREASED BY NORBORMIDE BOTH IN VITRO AND IN VIVO. NORBORMIDE INHIBITED THE (45)CALCIUM UPTAKE BY LIVER MITOCHONDRIA AS WELL AS MITOCHONDRIAL SUCCINATE DEHYDROGENASE ACTIVITIES.

For more Non-Human Toxicity Excerpts (Complete) data for NORBORMIDE (13 total), please visit the HSDB record page.

The rate constant for the vapor-phase reaction of norbormide with photochemically-produced hydroxyl radicals has been estimated as 2.2X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 1.7 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). Norbormide is not expected to undergo hydrolysis in the environment due to the lack of functional groups to hydrolyze(2,SRC).

Norbormide's former use as a rodenticide may have resulted in its release to the environment. If released to the atmosphere, norbormide is expected to exist entirely in the particulate phase in the ambient atmosphere based on an estimated vapor pressure of 4.3X10-22 mm Hg at 25 °C. Particulate-phase norbormide may be physically removed from the atmosphere by wet or dry deposition. If released to soil, norbormide is expected to have slight mobility based on an estimated Koc of 2000. Volatilization from wet and dry soil surfaces is not expected to occur based on an estimated Henry's Law constant of 2.7X10-23 atm-cu m/mole and the estimated vapor pressure for this compound, respectively. If released into water, norbormide is expected to adsorb to suspended solids and sediments in water based on its estimated Koc. An estimated BCF of 290 suggests that bioconcentration of norbormide in aquatic organisms is expected to occur. Norbormide is not expected to volatilize from water surfaces based on the Henry's Law constant for this compound. Occupational exposure to norbormide may have occurred through inhalation of dust particles and dermal contact with this rodenticide during its use or at workplaces where norbormide was produced. (SRC)

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Norbormide is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100/10,000 lbs.