アセチルコエンザイムA ナトリウム塩

解説アセチル補酵素A。アセチル CoAとも書く。生体内で糖質，脂質，アミノ酸などの代謝過程の出発点となる重要な中間代謝物質で，コエンザイムAとアセチル基がエネルギーに富んだチオエステル結合をしている。ドイツの F.リネンによって酵母から単離され (1951) ，構造が明らかにされた。これより先，アメリカの生化学者 F.リップマンは，解糖系で生じたピルビン酸が呼吸のクレブス回路に流入するとき活性型酢酸となることを示唆していたが，その正体がアセチルコエンザイムAだったのである。ブリタニカ国際大百科事典 小項目事典 ブリタニカ

説明Acetyl-coenzyme A (acetyl-CoA), the thioester of CoA and acetic acid, is a pivotal molecule in biological systems. Foremost, it serves as a source of carbon for the Krebs cycle, for the synthesis of fatty acids, and for isoprenoid-based protein modifications. Acetyl-CoA also serves as an intermediate in oxidation of fatty acids and amino acids and is formed by the oxidative decarboxylation of pyruvate in mitochondria. It is an essential cofactor or substrate for acetyltransferases and acyltransferases, as in the post-translational modification of proteins and in the synthesis of the neurotransmitter acetylcholine.

使用Acetyl-Coenzyme A is used to assay CAT enzyme activity in cell extracts using radioisotopes. CAT enzyme activity in cell extracts catalyzes the transfer of acetyl groups from acetylcoenzyme A to chloramphenicol. A number of assays have been developed to measure CAT activity in cell extracts. Acetyl-Coenzyme A has also been used to determine citrate synthase activity.

一般的な説明Acetyl-Coenzyme A, trilithium salt