Acetohydrazide (HCID 14039)

名称と識別子

優先名称: Acetohydrazide
IUPAC: acetohydrazide
現地名: アセトヒドラジド
英語名: Acethydrazide
分子式: C2H6N2O
分子量: 74.08

名称と別名

AcethydrazideAcetohydrazide1068-57-1AcetylhydrazineAcetic hydrazideAcetyl hydrazideMonoacetylhydrazineEthanehydrazonic acidN-AcetylhydrazineHydrazine, acetyl-ENT-61241acethydrazine

名称をさらに表示

アセトヒドラジド1-ヒドラゾノエタノールアセチルヒドラジド酢酸ヒドラジドアセチルヒドラジン1-アセチルヒドラジンエタンヒドラゾン酸アセチドラジド374AcetohydrazidAcetyl drazide

SK0DPC9098NSC-2271NSC-53155CHEBI:2422acetylhydrazideRefChem:552505213-948-7Acetic acid hydrazide

データベース識別子

CAS: 1068-57-1
PubChem CID: 14039
DTXSID: DTXSID9020900
ChEMBL: CHEMBL3091859
ChEBI: CHEBI:2422
UNII: SK0DPC9098
EC Number: 213-948-7
Nikkaji: J7.446B

物性

構造計算による物性

XLogP: -1.6
極性表面積: 55.1 Å²
水素結合供与体数: 2
水素結合受容体数: 2
回転可能結合数: 0
重原子数: 5
形式電荷: 0
複雑度: 42

物理化学的性質

融点: 58 · 58-68 °C (lit.)
沸点: 129 °C/18 · 129 °C/18 mmHg (lit.)
比重(密度): 1.0968 · 1.0968 (rough estimate)
屈折率: 1.4264 · 1.4264 (estimate)
闪点: 230 °F · >230 °F
貯蔵温度: 2 · Keep in dark place,Inert atmosphere,2-8°C
溶解性: DMSO (Slightly), Methanol (Slightly)
外見: 湿った結晶とチャンク
酸解離定数(Pka): 13.46 · 13.46±0.18(Predicted)
色: 白い
水溶解度: 溶ける
BRN: 506165 · 506165
InChI: 1S/C2H6N2O/c1-2(5)4-3/h3H2,1H3,(H,4,5)
InChIKey: OFLXLNCGODUUOT-UHFFFAOYSA-N
SMILES: CC(=O)NN
CAS データベース: 1068 · 1068-57-1(CAS DataBase Reference)
NISTの化学物質情報: Acetic acid, hydrazide(1068-57-1)
EPAの化学物質情報: Acetic acid hydrazide (1068-57-1)

化学的性質

化学的特性White moist crystals and chunks

安全と法規制

GHS分類

GHS Classification · 5 件

Danger

H301 (54.7%): Toxic if swallowed [Danger Acute toxicity, oral]；H302 (41.9%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (67.4%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (67.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H331 (32.6%): Toxic if inhaled [Danger Acute toxicity, inhalation]；H341 (54.7%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]；H351 (55.8%): Suspected of causing cancer [Warning Carcinogenicity]；H400 (32.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (32.6%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]；H411 (32.6%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P318, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 86 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 2 件

Status: Active Update: 05-04-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23789

Acetohydrazide: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesAcute Tox. 3 (54.7%)；Acute Tox. 4 (41.9%)；Skin Irrit. 2 (67.4%)；Eye Irrit. 2 (67.4%)；Acute Tox. 3 (32.6%)；Muta. 2 (54.7%)；Carc. 2 (55.8%)；Aquatic Acute 1 (32.6%)；Aquatic Chronic 2 (32.6%)

法規制情報

Regulatory Information · 2 件

Status: Active Update: 05-04-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23789

Acetohydrazide: Does not have an individual approval but may be used under an appropriate group standard

安全データ

F: 3-8-10
wgk: 1
tsca: TSCA listed
rtecs: AI1225000
ridadr: 1759
毒性: LD50 oral in bird - wild: 42200ug/kg
hs_code: 29280090
risk_code: 22-36/38-68-40-25
hazard_code: Xn,T
safety_code: 26-36-45-36/37
hazard_class: 6.1
packing_group: II
Hazard Classifications: Acute Tox. 3 OralCarc. 2Eye Irrit. 2Muta. 2Skin Irrit. 2
ストレージクラス: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects

化学と産業

薬理情報

MeSH Pharmacological ClassificationSubstances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.

Tissue LocationsKidney；Liver

用途と製造

General Manufacturing InformationAcetic acid, hydrazide: ACTIVE

調製方法

純化方法Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.]

上流・下流製品情報

上流原料

2-ブトキシエチルメタクリラート Acetamide,N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-ベンゾイル-2,4-ペンタンジオン 2-butanone (1-methylpropylidene)hydrazone Hydrazinecarboxylic acid, 2-acetyl-, 1,1-dimethylethyl ester (9CI)3,6-ジチア-1,8-オクタンジオールエタンイミド酸エチル·塩酸塩 1,3-ジフェニル-1,3-プロパンジオン 1-フェニル-1,3-ブタンジオンアセトアミド

下流製品

5-メチル-1,3,4-チアジアゾール-2-チオール 5-メチル-1,3,4-オキサジアゾール-2(3H)-オンフルブロマゾラム 2-アミノ-5-メチル-1,3,4-チアジアゾール 5-メチル-1,3,4-チアジアゾール-2-カルボン酸エチルメタンアミン?硝酸塩（1：1）2-アミノ-5-メチル-1,3,4-オキサジアゾール (6R)-6,9a-ジヒドロ-2,3,9-トリメチル-4-(4-クロロフェニル)-5,7,8,9a-テトラアザアズレノ[4,5-b]チオフェン-6-酢酸tert-ブチル

サプライヤー50 社

国药集团化学试剂有限公司86-21-63210123 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

INTATRADE GmbH+49 3493/605464 · [email protected]

爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

補足説明

定義ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.

アセトヒドラジド

基本情報