CAS 5959-95-5 D-Glutamine (HCID 145815)

概要

D-glutamine is the D-enantiomer of glutamine. It has a role as a mouse metabolite. It is a D-alpha-amino acid and a glutamine. It is a conjugate base of a D-glutaminium. It is a conjugate acid of a D-glutaminate. It is an enantiomer of a L-glutamine. It is a tautomer of a D-glutamine zwitterion.

名称と識別子

優先名称: D-Glutamine
IUPAC: (2R)-2,5-diamino-5-oxopentanoic acid
現地名: D-グルタミン
英語名: D-Glutamine
分子式: C5H10N2O3
分子量: 146.14

名称と別名

D-glutamine5959-95-5D-2-Aminoglutaramic acidGlutamine, D-(2R)-2-amino-4-carbamoylbutanoic acid(2R)-2,5-diamino-5-oxopentanoic acid(R)-2,5-diamino-5-oxopentanoic acidDTXSID604634563HB36CA2YDTXCID4026345CHEBI:17061RefChem:583856

名称をさらに表示

D-グルタミン(R)-2-アミノ-4-カルバモイルブタン酸(-)-D-グルタミン(-)-グルタミンD‐グルタミン(2R)-2-アミノ-4-カルバモイルブタン酸Ｄ(-)-グルタミンD-Gln-OHD-GIn-0HCAS5959-95-5D(-)-GLUTAMINED-Glutamine>D-Glutamine99+%dextro-glutamine

673-968-0H-D-Gln-OHD-GlnMFCD00065607(r)-2-amino-4-carbamoyl-butyric acidNCGC00163333-01M02933DGN

データベース識別子

CAS: 5959-95-5
PubChem CID: 145815
DTXSID: DTXSID6046345
ChEMBL: CHEMBL1232207
ChEBI: CHEBI:17061
UNII: 63HB36CA2Y
EC Number: 673-968-0
Nikkaji: J9.211H

物性

構造計算による物性

XLogP: -3.1
極性表面積: 106 Å²
水素結合供与体数: 3
水素結合受容体数: 4
回転可能結合数: 4
重原子数: 10
形式電荷: 0
複雑度: 146

実験および物理化学的性質

Physical DescriptionSolid

物理化学的性質

融点: 184 · 184-185 °C
比旋光度: -32 · -32 º (589nm, c=10, N HCl)
沸点: 265.74 °C · 265.74°C (rough estimate)
比重(密度): 1.3394 · 1.3394 (rough estimate)
屈折率: -33 ° · -33 ° (C=5, 5mol/L HCl)
貯蔵温度: Keep in dark place,Inert atmosphere,Room temperature
溶解性: 水（わずかに、超音波処理）
酸解離定数(Pka): 2.27 · 2.27±0.10(Predicted)
外見: 粉
色: 白い
水溶解度: 42.53 g/L · 42.53g/L(温度表記なし)
BRN: 1723796 · 1723796
主な用途: 細胞分析
InChI: 1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m1/s1
InChIKey: ZDXPYRJPNDTMRX-GSVOUGTGSA-N
SMILES: N[C@H](CCC(N)=O)C(O)=O
LogP: -1.576 · -1.576 (est)
CAS データベース: 5959 · 5959-95-5(CAS DataBase Reference)

化学的性質

化学的特性white crystalline powder

安全と法規制

GHS分類

GHS Classification · 4 件

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 3 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

安全データ

wgk: 3
hs_code: 29241900
risk_code: 36/37/38
hazard_code: Xi
safety_code: 36/37/39-26-27-24/25
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

Cellular LocationsCytoplasm

用途と製造

UsesUse (kg; approx.) in Germany (2009): >1000

応用分野 · 2 件

使用D-Glutamine is an unnatural isomer of L-Glutamine (G597000) that is present in human plasma an is a source of liberated ammonia. D-Glutamine can be synthesized by enzymatic means or can be found in cheeses, wine and vinegars as well. It is often used to determine the activity of Glutamine synthetase, an enzyme that is commonly found in the mammalian liver and brain that controls the use of nitrogen in cells.

一般的な説明Glutamine is a non-essential and the most abundant free amino acid present in the human body. It is an important component of proteins and is one of the 20 proteinogenic amino acids. It forms 5-6% of bound amino acids.