PROTEOMASS™インスリン MALDI-MSスタンダード

化学的特性Insulin is a relatively simple protein consisting of 51 amino acids arranged as two polypeptide chains, an α- chain and β-chain, connected by disulfide bonds; the latter are necessary to maintain tertiary structure and biological activity. Although the amino acid sequence and composition of animal insulins may differ slightly from those of human insulin, their biological actions are similar. Alteration of specific amino acid residues within the insulin molecule yields novel derivatives that vary in their pharmacokinetics and binding affinity for the insulin receptor. Some insulin analogues display mitogenic properties in addition to their metabolic effects.

解説血糖を低下させるすい(膵)臓のペプチドホルモン．インシュリンともいう．2本のポリペプチド鎖からなる．生体内でインスリンの作用不足が生じると糖尿病となる．遺伝子組換えによるヒトインスリンが実用化している．細胞のインスリンレセプターに結合し，細胞膜の糖透過性を上昇させ，各種の代謝酵素を調節するなどの多面的な作用をもつ．

使用Insulin is a peptide hormone regulating the metabolism of carbohydrates and fats. It is used in the treatment of those suffering from the diabetes type I and II metabolic disorders. Regulates the absorption of glucose from the blood to skeletal muscles and fat storage.