2,2'-ビピリジル

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

2,2'-BIPYRIDINE AT CONCENTRATIONS OF 1.0-5.0 MILLIMOLE GREATLY INCREASED THE COVALENT BINDING OF (14)C-LABELED CARBON TETRACHLORIDE TO RAT LIVER MICROSOMES.

BIOTRANSFORMATION OF M-FLUOROTYROSINE BY TYROSINE METABOLIC PATHWAY OF THE LIVER PLAYED AN IMPORTANT ROLE IN THE ELICITATION OF CONVULSIONS IN MICE BY M-FLUOROTYROSINE. SIMULTANEOUS ADMINISTRATION OF M-FLUOROTYROSINE & ALPHA,ALPHA-DIPYRIDYL PREVENTED THE APPEARANCE OF M-FLUOROTYROSINE INDUCED SEIZURES.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 160(SRC), determined from a log Kow of 1.5(2) and a regression-derived equation(3), indicates that 2,2'-bipyridine is expected to have moderate mobility in soil(SRC). Volatilization of 2,2'-bipyridine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.4X10-10 atm-cu m/mole(4). 2,2'-Bipyridine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.3X10-5 mm Hg(SRC), derived from a water solubility, 5.9X10+3 mg/l(5), and its estimated Henry's Law constant(4).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 160(SRC), determined from a log Kow of 1.5(2) and a regression-derived equation(3), indicates that 2,2'-bipyridine is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 5.4X10-10 atm-cu m/mole(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 2,2'-Bipyridine was shown to undergo slow oxidation with photochemically generated hydroxyl radicals in aqueous solution (half-life of about 129 days)(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,2'-bipyridine, which has an estimated vapor pressure of 1.3X10-5 mm Hg at 25 °C(SRC), derived from a water solubility, 5.9X10+3 mg/l(2), and an estimated Henry's Law constant, 5.3X10-10 atm-cu m/mole(3), will exist in both the vapor and particulate phases in the ambient atmosphere(SRC). Vapor-phase 2,2'-bipyridine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 12.5 days(SRC), calculated from its rate constant of 1.3X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(4). Particulate-phase 2,2'-bipyridine may be removed from the air by wet and dry deposition(SRC).

Cough. Sore throat.

Redness. Pain.

Redness. Pain.

Burning sensation in the throat and chest. Nausea. Vomiting.

The Koc of 2,2'-bipyridine is estimated as 160(SRC), using a log Kow of 1.5(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2,2'-bipyridine is expected to have moderate mobility in soil(SRC).

The Henry's Law constant for 2,2'-bipyridine is estimated as 5.4X10-10 atm-cu m/mole(1). This Henry's Law constant indicates that 2,2'-bipyridine is expected to be essentially nonvolatile from water surfaces(2). 2,2'-Bipyridine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.3X10-5 mm Hg(SRC), derived from its water solubility, 5.9X10+3 mg/l(3), and an estimated Henry's Law constant(1).

IN RATS & MICE ALPHA,ALPHA-DIPYRIDYL DECREASED THE LEVEL OF NOREPINEPHRINE & INHIBITED DOPAMINE-BETA-HYDROXYLASE ACTIVITY IN THE BRAIN IN A DOSE DEPENDENT MANNER. DOPAMINE & 5-HYDROXYTRYPTAMINE LEVELS WERE NOT AFFECTED.

THE DEPLETION OF NOREPINEPHRINE IN RAT BRAIN & OTHER TISSUES DID NOT APPEAR TO BE RELATED TO THE TREMORS, HYPOTHERMIA, & HYPOTENSION PRODUCED BY ALPHA,ALPHA'-DIPYRIDYL.

2,2'-BIPYRIDYL ADMINISTERED INTRAPERITONEALLY OR ORALLY IN DOSES OF 250, 100, & 50 MG/KG TO RATS CAUSED TREMORS & SLIGHT PTOSIS WHICH COMPLETELY DISAPPEARED IN 24 HOURS.

THE MUTAGENICITIES OF 18 SUPEROXIDE GENERATING COMPOUNDS WERE SCREENED BY AMES/SALMONELLA METHOD. ALPHA,ALPHA'-DIPYRIDYL WAS MUTAGENIC.

For more Non-Human Toxicity Excerpts (Complete) data for 2,2'-BIPYRIDINE (9 total), please visit the HSDB record page.

The rate constant for the vapor-phase reaction of 2,2'-bipyridine with photochemically-produced hydroxyl radicals has been estimated as 1.3X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 12 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the reaction of 2,2'-bipyridine with photochemically-produced hydroxyl radicals in water has been measured to be 6.2X10+9 M-1 sec-1 at 21 °C and a pH of 9.3(2), which corresponds to an aqueous half-life of about 129 days at a hydroxyl radical concn of 1X10-17 M(3). 2,2'-Bipyridine is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(4). Data are not available to assess this compound's potential for direct photolysis.

Used as an iron chelating agent, indicator for photometric determination of metals (Ag, Cd, Cu, Fe, and Mo), and chemical intermediate in the production of the herbicide diquat; [HSDB] Formed as a pyrolysis product in tobacco smoke and also from the degradation of the herbicide paraquat; [Reference #1]

Smoking cigarettes [Category: Food & Drugs]

Iron chelating agent

Indicator for photometric determination of Ag, Cd, Cu, Fe, and Mo

Important chemical intermediate in the production of the herbicide diquat; the quaternary salt is used as a contact herbicide.

Dehydrogenation of pyridine with nickel or other metal catalysts gives 2,2'-bipyridyl.

Raney nickel reduction /of pyridine/ gives 2,2'-bipyridine.