基本情報
- CAS
14639-25-9- 標準SMILES
O=C([O-])c1ccccn1.O=C([O-])c1ccccn1.O=C([O-])c1ccccn1.[Cr+3]- InChIKey
CBDQOLKNTOMMTL-UHFFFAOYSA-K- 分子式
- C18H12CrN3O6
- 平均分子量
- 418.3 g/mol
概要
Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are shown to regulate insulin by promoting glucose utilization and increasing the sensitivity of the insulin receptor.
名称と識別子
- 優先名称
- Chromium(III) picolinate
- IUPAC
- chromium(3+);tris(pyridine-2-carboxylate)
- 現地名
- ピコリン酸 クロム(ＩＩＩ)
- 英語名
- Chromium picolinate
- 分子式
- C18H12CrN3O6
- 分子量
- 418.3
名称と別名
Chromium picolinate14639-25-9Chromium(III) PicolinateDTXSID1024831Chromium(III) trispicolinateChromaxDivistaPicolinic acid, chromium saltChromium 2-pyridinecarboxylatetris(picolinato)chromiumDTXCID304831S71T8B8Z6P
名称をさらに表示
ピコリン酸 クロム(ＩＩＩ)ピリジン-2-カルボン酸クロム(III)ピコリン酸クロム(ＩＩＩ)ピコリン酸クロムトリピコリン酸クロム(III)ピコリン酸/クロムトリス(ピリジン-2-イルカルボニルオキシ)クロム(III)トリス(ピリジン-2-カルボン酸)クロム(III)ビス(ピリジン-2-カルボニルオキシ)クロミオ ピリジン-2-カルボキシラートトリスピコリン酸クロム(III)CHROME PICOLINATECHROMIUM TRIPICOLINATEPicolinic acid chromiumCHROMIUM(III) PYRIDINE-2-CARBOXYLATECr(pic)3Ccris 8310Chromium picoLChromium benzoate
2-Pyridinecarboxylic acid, chromium saltCHEBI:50369tris(2-pyridinecarboxylato-N(1),O(2))chromiumCrPicChromium, tris(2-pyridinecarboxylato-kappaN1,kappaO2)-RefChem:58289bis(pyridine-2-carbonyloxy)chromio pyridine-2-carboxylate477-680-4
物性
構造計算による物性
- 極性表面積
- 159 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 9
- 回転可能結合数
- 0
- 重原子数
- 28
- 形式電荷
- 0
- 複雑度
- 108
実験および物理化学的性質
Chemical ClassesMetals -> Chromium Compounds, Inorganic
Physical DescriptionRuby red crystals; Soluble in water at 1 ppm at 20 deg C; [ACGIH]
物理化学的性質
- 融点
- 300 °C · >300°C
- 貯蔵温度
- room temp
- 溶解性
- DMSO（微加熱）
- 外見
- 個体
- 色
- 暗赤色
- 臭い (Odor)
- 100 %で。無臭 · 100.00%で。無臭
- 由来生物
- synthetic
- Merck
- 14 · 14,2236
- InChI
- InChI=1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3
- InChIKey
- CBDQOLKNTOMMTL-UHFFFAOYSA-K
- SMILES
- O=C1C2C=CC=CN=2[Cr+3]23([O-]C(=O)C4C=CC=CN2=4)([O-]C(=O)C2C=CC=CN3=2)[O-]1
- CAS データベース
- 14639 · 14639-25-9(CAS DataBase Reference)
- EPAの化学物質情報
- Chromium, tris(2-pyridinecarboxylato-.kappa.N1,.kappa.O2)- (14639-25-9)
化学的性質
安全と法規制
GHS分類
GHS Classification
Warning
H315 (94.9%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 99 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Warning
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
危険有害性情報
Regulatory Information
Directive (EC) No 46/2002
Status: Active Update: 10-11-2008 https://echa.europa.eu/registration-dossier/-/registered-dossier/2842
Chromium picolinate: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryThe trivalent form of Cr is 500-1000 times less toxic than the hexavalent form. Organic Cr-containing complexes of toxicological importance have not been reported. [Nordberg, p. 718]
Hazard Classes and Categories
Skin Sens. 1 (100%)
Skin Irrit. 2 (94.9%)
安全と保護具
Threshold Limit Values (TLV)0.003 [mg/m3], as Cr(III), inhalable particulate matter
Permissible Exposure Limit (PEL)0.5 [mg/m3]
毒性情報
TreatmentThere is no know antidote for chromium poisoning. Exposure is usually handled with symptomatic treatment. (L16)
化学と産業
薬理情報
Metabolism/Metabolites
Chromium is absorbed from oral, inhalation, or dermal exposure and distributes to nearly all tissues, with the highest concentrations found in kidney and liver. Bone is also a major storage site and may contribute to long-term retention. Hexavalent chromium's similarity to sulfate and chromate allow it to be transported into cells via sulfate transport mechanisms. Inside the cell, hexavalent chromium is reduced first to pentavalent chromium, then to trivalent chromium by many substances including ascorbate, glutathione, and nicotinamide adenine dinucleotide. Chromium is almost entirely excreted with the urine. (A12, L16)
MeSH Pharmacological Classification
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.
用途と製造
Uses
Used as a chromium supplement; [Merck Index]
Chromium(III) picolinate is found in nutritional supplements to prevent or treat chromium deficiency.
応用分野
使用Chromium picolinate (CrPic), a dietay supplement, may be used to study its potential as a modulator of glucose uptake and the activity of insulin. CrPic is used to study its effects on nuclear factor-κ B (NF-κB) and nuclear factor-E2-related factor-2 (Nrf2) pathways in animals.
一般的な説明Chromium picolinate is a supplemental or alternative medication for type 2 diabetes and an anti-diabetic mechanisms of CrPic in insulin-resistant 3T3-L1 adipocytes.
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