基本情報
- CAS
170861-63-9- 標準SMILES
Cc1oc(-c2ccccc2)nc1CCOc1ccc(CC2C(=O)NOC2=O)cc1- InChIKey
QBQLYIISSRXYKL-UHFFFAOYSA-N- 分子式
- C22H20N2O5
- 平均分子量
- 392.4 g/mol
- 単同位体質量
- 392.13722174
概要
Reglitazar, an isoxazolidine-3,5-dione derivative, is being developed by Pfizer for the treatment of diabetes. It is the first non-thiazolidenedione to enter clinical trials.
名称と識別子
- 優先名称
- Reglitazar
- IUPAC
- 4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione
- 現地名
- レグリタザル
- 英語名
- 4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]isoxazolidine-3,5-dione
- 分子式
- C22H20N2O5
- 分子量
- 392.4
名称と別名
Reglitazar170861-63-9JTT-501P9UTN18JVV4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dioneJTT 501JT-501JTT501DTXSID008701093,5-Isoxazolidinedione, 4-((4-(2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy)phenyl)methyl)-(4RS)-4-(4-(2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy)benzyl)-3,5-isoxazolidinedione4-({4-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}methyl)-1,2-oxazolidine-3,5-dione
名称をさらに表示
レグリタザルレグリタザル (JAN)PNU-716PNU182716PNU-182716JTT-501(Reglitazar)3,5-Isoxazolidinedione, 4-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]-4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]isoxazolidine-3,5-dione
4-((4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)methyl)-1,2-oxazolidine-3,5-dioneREGLITAZARUMRefChem:879063JTT-501BETADTXCID00817933JT 501Reglitazar [INN]JTT-501.BETA.
物性
構造計算による物性
- XLogP
- 4
- 極性表面積
- 90.7 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 6
- 回転可能結合数
- 7
- 重原子数
- 29
- 形式電荷
- 0
- 複雑度
- 572
化学と産業
薬理情報
Pharmacodynamics
Reglixane shows a hypoglycemic effect and also a stronger triglyceride-lowering effect than the thiazolidine-2,4-diones. In preclinical studies, reglixane has been shown to prevent several diabetic complications, such as cataract, nephropathy, and neuropathy.
Mechanism of ActionReglixane is an agonist of peroxisome proliferator-activated receptor (PPAR) gamma and alpha.
上流・下流製品情報
上流原料
サプライヤー9 社
沈阳中申泽康生物医学技术研究有限公司024-88590548 18698872706 · [email protected]
Alfa Chemistry1-516-6625404 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
Alfa Chemistry+1-5166625404 · [email protected]
苏州美石生物科技有限公司1173954148q · [email protected]
関連反応
0 件
現在のフィルター条件では反応記録がありません。
化合物ノート
読み込み中…