基本情報
- 標準SMILES
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cc3ccccc3cc2c1- InChIKey
ZITQUAHPZJHCJH-UHFFFAOYSA-N- 分子式
- C29H29Cl2N3O
- 平均分子量
- 506.5 g/mol
概要
a dopamine D3 receptor antagonist; structure in first source
名称と識別子
- 優先名称
- Ngb-2849
- IUPAC
- N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]anthracene-2-carboxamide
名称と別名
NGB284926P8N956NZNGB-2849197242-80-1RefChem:927696NGB 2849UNII-26P8N956NZN-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyl)-2-anthracenecarboxamide2-Anthracenecarboxamide, N-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyl)-N-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl}-2-anthracenecarboxamideorb1739455SCHEMBL8183795
名称をさらに表示
ZITQUAHPZJHCJH-UHFFFAOYSA-N
データベース識別子
- CAS
197242-80-1- PubChem CID
- 15411150
- UNII
- 26P8N956NZ
- Nikkaji
- J959.637B
物性
構造計算による物性
- XLogP
- 7
- 極性表面積
- 35.6 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 3
- 回転可能結合数
- 7
- 重原子数
- 35
- 形式電荷
- 0
- 複雑度
- 685
化学と産業
薬理情報
MeSH Pharmacological Classification
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
関連反応
4 件
関連ノート
読み込み中…