CAS 144035-83-6 Piclamilast (HCID 154575)

名称と識別子

優先名称: Piclamilast
IUPAC: 3-cyclopentyloxy-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide
現地名: ピクラミラスト
英語名: Piclamilast
分子式: C18H18Cl2N2O3
分子量: 381.25

名称と別名

Piclamilast144035-83-63-(Cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamideRP 73401RP-73401RPR-734013-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamideRP 73-401RP-73-401piclamilastum3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamideRP73401

名称をさらに表示

ピクラミラストN-(3,5-ジクロロ-4-ピリジル)-3-(シクロペンチルオキシ)-4-メトキシベンズアミドN-(3,5-ジクロロ-4-ピリジニル)-3-(シクロペンチルオキシ)-4-メトキシベンズアミド3-(シクロペンチルオキシ)-N-(3,5-ジクロロピリジン-4-イル)-4-メトキシベンズアミドN-(3,5-ジクロロピリジン-4-イル)-3-(シクロペンチルオキシ)-4-メトキシベンズアミドRPR 73401piclamilasPiclamilast, 10 mM in DMSON-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamideBenzamide,3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-

Benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamideWM58D7C3ZT3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-p-anisamideDTXSID3040227CHEBI:47619RefChem:863110DTXCID1020227

データベース識別子

CAS: 144035-83-6
PubChem CID: 154575
DTXSID: DTXSID3040227
ChEMBL: CHEMBL42126
ChEBI: CHEBI:47619
UNII: WM58D7C3ZT
EC Number: 802-857-3
Nikkaji: J623.884J

物性

構造計算による物性

XLogP: 4.2
極性表面積: 60.5 Å²
水素結合供与体数: 1
水素結合受容体数: 4
回転可能結合数: 5
重原子数: 25
形式電荷: 0
複雑度: 438

物理化学的性質

沸点: 447.8 · 447.8±45.0 °C(Predicted)
比重(密度): 1.37 · 1.370
貯蔵温度: 2 · 2-8°C
溶解性: 20 mg/mL、透明 · DMSO：可溶20mg/mL、透明
酸解離定数(Pka): 10.1 · 10.10±0.70(Predicted)
外見: 粉
色: 白からベージュ
InChI: 1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)
InChIKey: RRRUXBQSQLKHEL-UHFFFAOYSA-N
SMILES: Clc1cncc(c1NC(=O)c2cc(c(cc2)OC)OC3CCCC3)Cl

安全と法規制

GHS分類

GHS Classification · 5 件

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Hazard Classes and CategoriesSkin Irrit. 2 (100%)；Eye Irrit. 2 (100%)；STOT SE 3 (100%)

安全データ

wgk: 3
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

Metabolism/MetabolitesRP73401 has known human metabolites that include N-(3,5-Dichloropyridin-4-yl)-3-(3-hydroxycyclopentyl)oxy-4-methoxybenzamide.

MeSH Pharmacological ClassificationCompounds that specifically inhibit PHOSPHODIESTERASE 4.

応用分野 · 1 件

使用Piclamilast is a potent and selective phosphodiesterase-4 (PDE4) inhibitor. Piclamilast may offer therapeutic strategies in respiratory diseases, including asthma and chronic obstructive pulmonary disease. Piclamilast may also provide a treatment option for pre-term infants with bronchopulmonary dysplasia (BPD).

サプライヤー35 社

上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]

上海冬洋生物科技有限公司0512-13601744364 13601744364

芷威（上海）化学科技有限公司021-20221225 13917446399 · [email protected]

United Life Science020-82099279 18988941402 · [email protected]

InvivoChem中国13549236410 · [email protected]

補足説明

定義ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 3-(cyclopentyloxy)-4-methoxybenzoic acid with the primary amino group of 3,5-dichloropyridin-4-amine.