N,N'-ジメチルホスホロジアミド酸フェニル

WHITE CRYSTALLINE SOLID

Colorless solid

IN WATER 4%; SOL IN ACETONE, CHLOROFORM, METHANOL, METHYLENE CHLORIDE

INSOL IN NON-POLAR SOLVENTS

Water solubility ca. 30 g/L

Water solubility = 50,000 mg/L

0.000362 [mmHg]

VERY LOW

A mild skin irritant; Depressed erythrocyte, plasma, and brain cholinesterase in 90 day animal feeding studies; [HSDB] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Diamidofos is found on List B. Case No: 2155; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Phenyl N,N'-dimethylphosphorodiamidate; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SLIGHT SKIN IRRITANT.

SYMPTOMATOLOGY: 1. NAUSEA...VOMITING, ABDOMINAL CRAMPS, DIARRHEA, EXCESSIVE SALIVATION... 2. HEADACHE, GIDDINESS, VERTIGO & WEAKNESS. 3. RHINORRHEA & SENSATION OF TIGHTNESS IN CHEST ARE COMMON IN INHALATION EXPOSURE. 4. BLURRING OR DIMNESS OF VISION, MIOSIS...TEARING, CILIARY MUSCLE SPASM, LOSS OF ACCOMMODATION & OCULAR PAIN... MYDRIASIS...SOMETIMES SEEN...PROBABLY DUE TO SYMPATHO-ADRENAL DISCHARGE. 5. LOSS OF MUSCLE COORDINATION, SLURRING OF SPEECH, FASCICULATIONS & TWITCHING OF MUSCLES (PARTICULARLY OF TONGUE & EYELIDS), & GENERALIZED PROFOUND WEAKNESS. 6. MENTAL CONFUSION, DISORIENTATION & DROWSINESS. 7. DIFFICULTY IN BREATHING, EXCESSIVE SECRETION OF SALIVA & OF RESP TRACT MUCUS, ORONASAL FROTHING, CYANOSIS, PULMONARY RALES & RHONCHI & HYPERTENSION, (PRESUMABLY DUE TO ASPHYXIA). 8. RANDOM JERKY MOVEMENTS, INCONTINENCE, CONVULSIONS, & COMA. 9. DEATH PRIMARILY DUE TO RESP ARREST ARISING FROM FAILURE OF RESP CENTER, PARALYSIS OF RESP MUSCLES, INTENSE BRONCHOCONSTRICTION OR ALL THREE. /PARATHION/

TOXICITY TO FISH & CERTAIN OTHER AQUATIC ANIMALS IS OF RELATIVELY LOW ORDER.

/Nellite/ ... has a high oral toxicity ... Animals given 100 ppm in food for 90 days showed depressed cholinesterase levels in brain, plasma and erythrocytes.

LD50 Rat oral 200 mg/kg

LD50 Rabbit percutaneous <200 mg/kg

LD50 Rat oral 140 mg/kg

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Diamidofos is found on List B. Case No: 2155; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Phenyl N,N'-dimethylphosphorodiamidate; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

THE PHOSPHORODIAMIDATE, DIAMIDAFOS (PHENYL N,N'-DIMETHYLPHOSPHORODIAMIDATE), WAS RAPIDLY METABOLIZED BY THE RAT TO YIELD PRODUCTS OF OXIDATIVE ATTACK AT THE N-METHYL GROUP...& OF HYDROLYTIC ATTACK AT THE P-O BOND TO YIELD PHENOL (AS CONJUGATE). ANALYSIS OF MILK FOLLOWING DOSAGE...TO COW REVEALED...SAME METABOLITES.

When tobacco was treated with (14)C-diamidfos, in addition to unchanged diamidfos and unextractable material, phenyl beta-D-glucopyranoside and a glycoside of phenol were observed. In tobacco smoke, the major breakdown product was phenol.

URINE FROM SPRAGUE-DAWLEY RATS AFTER ORAL OR IV ADMIN OF DIAMIDAFOS CONTAINED PHENYL N-METHYL-PHOSPHORODIAMIDATE, PHENYL N-METHYL-N-FORMYL PHOSPHORODIAMIDATE, AND CONJUGATED PHENOL.

AFTER ADMIN OF (14)C-DIAMIDFOS TO RATS IN IV DOSES OF 1 AND 25 MG/KG, CLEARANCE OF (14)C ACTIVITY FROM PLASMA WAS BY AN APPARENT FIRST ORDER PROCESS WITH HALF-LIFE VALUES OF 2.94 AND 3.08 HR, RESPECTIVELY.

APPROX 84% OF ORAL OR IV DOSE OF DIAMIDAFOS IN SPRAGUE-DAWLEY RATS WAS EXCRETED IN URINE DURING FIRST 36 HR & APPROX 4% MORE OVER NEXT 36 HR.

/Nellite/ ... is readily absorbed from the gut ... also ... through intact skin ...

Used as soil fumigant and nematocide; [HSDB]

Cancelled--no longer registered as a pesticide for use in the US; [HSDB]

Farming (Pesticides) [Category: Industry]

The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

A soil fumigant and nematocide /Former use/

Nematocide /Former use/