4,4'-メチレンビス(N-メチルアニリン)

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 4,4'-methylenebis(N-methylaniline) can be estimated to be 1.0X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that 4,4'-methylenebis(N-methylaniline) is expected to be immobile in soil.

An estimated BCF of 66 was calculated for 4,4'-methylenebis(N-methylaniline)(SRC), using an estimated log Kow of 3.28(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

The Henry's Law constant for 4,4'-methylenebis(N-methylaniline) is estimated as 2.9X10-10 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 4,4'-methylenebis(N-methylaniline) is expected to be essentially nonvolatile from water surfaces(2). 4,4'-Methylenebis(N-methylaniline) is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.8E-5 mm Hg(SRC), determined from a fragment constant method(3).

/GENOTOXICITY/ Although none of the microsomal metabolites was a direct-acting mutagen in the standard Salmonella typhimurium assay, all could be activated to mutagens when incubated with 9000 X g liver supernatants and reduced nicotinamide adenine dinucleotide phosphate. The activation of 4,4'-methylenedianiline to a mutagen suggests that the methyl groups of /reduced Michler's ketone, RMK)/ are not required for the conversion of RMK to a reactive electrophile.

The rate constant for the vapor-phase reaction of 4,4'-methylenebis(N-methylaniline) with photochemically-produced hydroxyl radicals has been estimated as 1.1X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 3.6 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 4,4'-Methylenebis(N-methylaniline) is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 4,4'-Methylenebis(N-methylaniline) contains chromophores that absorb at wavelengths >290 nm(2) and therefore may be susceptible to direct photolysis by sunlight(SRC).

4,4'-Methylenebis(N-methylaniline)'s former production and use as a chemical intermediate may have resulted in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 1.8X10-5 mm Hg at 25 °C indicates 4,4'-methylenebis(N-methylaniline) will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase 4,4'-methylenebis(N-methylaniline) will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 3.6 hours. Particulate-phase 4,4'-methylenebis(N-methylaniline) will be removed from the atmosphere by wet or dry deposition. 4,4'-Methylenebis(N-methylaniline)contains chromophores that absorb at wavelengths >290 nm and therefore may be susceptible to direct photolysis by sunlight. If released to soil, 4,4'-methylenebis(N-methylaniline) is expected to have no mobility based upon an estimated Koc of 1.0X10+4. Volatilization from moist soil surfaces is not expected to be an important fate process based uponan estimated Henry's Law constant of 2.9X10-10 atm-cu m/mole. 4,4'-Methylenebis(N-methylaniline) is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation data were not available. If released into water, 4,4'-methylenebis(N-methylaniline) is expected to adsorb to suspended solids and sediment based upon the estimated Koc. No data are available pertaining to biodegradation in aquatic environments. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 66 suggests the potential for bioconcentration in aquatic organisms is moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to 4,4'-methylenebis(N-methylaniline) may occur through dermal contact with this compound at workplaces where 4,4'-methylenebis(N-methylaniline) is produced or used. (SRC)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Aniline and related compounds/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aniline and related compounds/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. DIRECT PHYSICIAN ORDER ONLY ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Aniline and related compounds/