6-ヒドロキシドーパミン·塩酸塩

6-Hydroxydopamine hydrochloride

HCID 160157

基本情報

CAS
28094-15-7
標準SMILES
Cl.NCCc1cc(O)c(O)cc1O
InChIKey
QLMRJHFAGVFUAC-UHFFFAOYSA-N
分子式
C8H12ClNO3
平均分子量
205.64 g/mol
単同位体質量
205.0505709

名称と識別子

優先名称
6-Hydroxydopamine hydrochloride
IUPAC
5-(2-aminoethyl)benzene-1,2,4-triol;hydrochloride
現地名
6-ヒドロキシドーパミン·塩酸塩
英語名
6-Hydroxydopamine hydrochloride
分子式
C8H12ClNO3
分子量
205.64

名称と別名

Oxidopamine hydrochloride28094-15-76-Hydroxydopamine hydrochloride6-Hydroxydopamine chlorideOxidopamine HCl2,4,5-Trihydroxyphenethylamine hydrochlorideDTXSID00458389WBV30HXTL5-(2-Aminoethyl)-1,2,4-benzenetriol hydrochloride1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrochlorideNSC-233898DTXCID8025838
名称をさらに表示
塩酸6-ヒドロキシドパミン塩酸6-ヒドロキシドーパミン5-(2-アミノエチル)-1,2,4-ベンゼントリオール·塩酸塩6-ヒドロキシドパミン塩酸塩6-ヒドロキシドーパミン塩酸塩6-ヒドロキシドーパミン·塩酸塩6-ヒドロキシドーパミン 塩酸塩6-OHDA6-Hd HClNsc233898OxydopaMine HCLTIMTEC-BB SBB0034966-OHDA hydrochloride6-Hydroxydopamine hyTopaMine Hydrochloride
RefChem:168922248-837-25-(2-aminoethyl)benzene-1,2,4-triol hydrochlorideOxidopamine (hydrochloride)6-HYDROXYDOPAMINEHYDROCHLORIDE5-(2-aminoethyl)benzene-1,2,4-triol;hydrochlorideNSC 233898MFCD00012895

データベース識別子

CAS
28094-15-7
PubChem CID
160157
DTXSID
DTXSID0045838
ChEMBL
CHEMBL451197
ChEBI
CHEBI:232990
UNII
9WBV30HXTL
EC Number
248-837-2

物性

構造計算による物性

極性表面積
86.7 Ų
水素結合供与体数
5
水素結合受容体数
4
回転可能結合数
2
重原子数
13

実験および物理化学的性質

Melting Point450 to 451 °F (Decomposes) (NTP, 1992)
Physical Description · 2 件

6-hydroxydopamine hydrochloride is a beige solid. (NTP, 1992)

Beige hygroscopic solid; [CAMEO] Light brown powder; [Sigma-Aldrich MSDS]

物理化学的性質

融点
232 · 232-233 °C (dec.)(lit.)
貯蔵温度
room temp
溶解性
2 O: · H2O: >50 mg/mL、透明、黄色から茶色
外見
粉
色
オフホワイトからブラウン
水溶解度
2 O: · H2O: >50mg/mL, clear, yellow to brown

安全と法規制

GHS分類

GHS Classification · 5 件

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Fire HazardsFlash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
Health HazardsACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes. (NTP, 1992)
Hazards SummaryAffects dopamine levels in striatum of CNS causing rigidity in acute intracerebral studies of rats; [RTECS] A skin and strong eye irritant; Targets the nerves, heart, and GI tract; [Sigma-Aldrich MSDS]
Reactive GroupPhenols and Cresols;Salts, Acidic
Reactivity Profile · 1 件

A weak acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Air and Water ReactionsHygroscopic. Water soluble.

安全と保護具

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.;SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.;INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.;INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Nonfire Spill ResponseSTORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)
Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

毒性情報

Adverse EffectsNeurotoxin - Other CNS neurotoxin

安全データ

F
3-8-10-23
wgk
3
rtecs
DC4650000
risk_code
36/37/38
hazard_code
Xi
safety_code
26-36

化学と産業

薬理情報

MeSH Pharmacological Classification · 2 件

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

用途と製造

UsesDepletes neurons of catecholamines. [NTP]
応用分野 · 3 件

説明6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.

使用6-hydroxydopamine hydrochloride has been used:to induce Parkinson′s disease (PD) in ratsto analyse cytotoxic effect of 6-OHDA on PC12 cell lineto induce noradrenergic (NA) neuron deletion from the locus-coeruleus

一般的な説明Beige solid.

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