3-ヒドロキシ-2,2-ジメチルプロピオン酸ラクトン

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=1955-45-9]

Pivalolactone

TR-140: Bioassay of Pivalolactone for Possible Carcinogenicity (CASRN 1955-45-9) (1978 )

06/29/78

Clear Evidence

Clear Evidence

No Evidence

The bioassay of pivalolactone for possible carcinogenicity was conducted using Fischer 344 rats and B6C3Fl mice. Pivalolactone in water was admin by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species. The high and low dosages of pivalolactone utilized were, respectively, 300 and 150 mg/kg/day for rats and 150 and 75 mg/kg/day for mice. After a 103 wk period of compound admin for rats and a 102 wk period of cmpd admin for mice, rats were observed for 2 additional wk and mice for 1 additional wk. Twenty animals of each sex and species were placed on test as vehicle controls. ... This study provided no evidence for the carcinogenicity of pivalolactone in B6C3Fl mice of either sex. ... Levels of Evidence of Carcinogenicity: Male Rats: Positive; Female Rats: Positive; Male Mice: Negative; Female Mice: Negative.