基本情報
- CAS
861998-00-7- 標準SMILES
CN(C)N(C)C(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1.Cl- InChIKey
VFYAEUWJFGTGGO-GHTUPXNNSA-N- 分子式
- C31H43ClN6O3
- 平均分子量
- 583.2 g/mol
- 単同位体質量
- 582.3085169
概要
Anamorelin Hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite.
名称と識別子
- 優先名称
- Anamorelin Hydrochloride
- IUPAC
- 2-amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide;hydrochloride
- 現地名
- アナモレリン塩酸塩
- 英語名
- AnaMorelin hydrochloride
- 分子式
- C31H43ClN6O3
- 分子量
- 583.16452
名称と別名
Anamorelin hydrochloride861998-00-7Anamorelin HClRC-1291 HCL55F75LJQ0VDTXSID70235443RefChem:558018DTXCID70157934Anamorelin (hydrochloride)Anamorelin hydrochloride [USAN]MFCD23098788RC-1291 hydrochloride;ONO-7643 hydrochloride
名称をさらに表示
アナモレリン塩酸塩アナモレリン塩酸塩 (JAN)RC 1291 HClRC 1291 hydrochlorideAlamorim hydrochlorideONO-7643 hydrochlorideAnamorin HydrochlorideAnamorelin (RC-1291) HClAnamorelin MonohydrochlorideAnamorelin (RC-1291) hydrochloride
(3R)-1-((2R)-2-((2-Amino-2-methylpropanoyl)amino)-3-(indol-3-yl)propanoyl)-3-benzyl-N,N',N'-trimethylpiperidine-3-carbohydrazide hydrochloride2-amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide;hydrochloride3-Piperidinecarboxylic acid, 1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-, trimethylhydrazide, monohydrochloride, (3R)-UNII-55F75LJQ0VAnamorelin?(3R)-1-(2-Methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic Acid Trimethylhydrazide Monohydrochloride; RC 1291 HCl; RC 1291 HydrochlorideAdlumiz (TN)Anamorelin hydrochloride?
物性
構造計算による物性
- 極性表面積
- 115 Ų
- 水素結合供与体数
- 4
- 水素結合受容体数
- 5
- 回転可能結合数
- 9
- 重原子数
- 41
- 形式電荷
- 0
- 複雑度
- 904
物理化学的性質
- 貯蔵温度
- -20 °C · Store at -20°C
- 溶解性
- 28 · DMSO:28.0(Max Conc. mg/mL);48.01(Max Conc. mM)
- 外見
- Powder
- 色
- White to off-white
- InChIKey
- VFYAEUWJFGTGGO-LQVXCNOLNA-N
- SMILES
- C(N[C@H](CC1C2=C(NC=1)C=CC=C2)C(N1CCC[C@](CC2=CC=CC=C2)(C(=O)N(N(C)C)C)C1)=O)(=O)C(N)(C)C.[H]Cl |&1:2,18,r|
化学と産業
応用分野
説明Anamorelin Monohydrochloride, also known as ONO-7643, RC-1291, and ST-1291, is a drug developed by Novo Nordisk A/S and later licensed by Helsinn Healthcare SA and Ono Pharmaceutical Co. Anamorelin is used for the treatment of cancer anorexia and cachexia syndrome (CACS), a cancer-related side effect manifested by loss of appetite, weight loss, muscle wasting, and reduced quality of life.
サプライヤー84 社
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Aladdin Scientific[email protected]
湖北辰心化工有限公司18696113233 · [email protected]
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