G418二硫酸塩

(2S,3S,4S,5S)-2-((1S,2S,3R,4S,6R)-4,6-diamino-3-((2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl)oxy-2-hydroxycyclohexyl)oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid

HCID 16218858
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基本情報

CAS
108321-42-2
標準SMILES
CN[C@H]1[C@H](O)[C@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@@]1(C)O.O=S(=O)(O)O.O=S(=O)(O)O
InChIKey
UHEPSJJJMTWUCP-NKCAIAFTSA-N
分子式
C20H44N4O18S2
平均分子量
692.7 g/mol

名称と識別子

優先名称
(2S,3S,4S,5S)-2-((1S,2S,3R,4S,6R)-4,6-diamino-3-((2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl)oxy-2-hydroxycyclohexyl)oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
IUPAC
(2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
現地名
G418二硫酸塩
英語名
Geneticin
分子式
C20H42N4O14S
分子量
594.63

名称と別名

(2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid(2S,3S,4S,5S)-2-((1S,2S,3R,4S,6R)-4,6-diamino-3-((2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl)oxy-2-hydroxycyclohexyl)oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acidRefChem:398888600-864-4108321-42-2G 418 disulfate saltG418 DisulfateG-418.Sulfate SolidGeneticin disulfateM018012-[4,6-Diamino-3-[3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acidGeneticin disulfate salt
名称をさらに表示
G418硫酸塩G418硫酸塩溶液,ろ過滅菌済G418二硫酸塩G‐418硫酸塩(ジェネティシン)50MG/ML ジェネティシン溶液G-418硫酸塩G 418 SULFATEG 418 二硫酸塩G 418 二硫酸塩 溶液G 418G418 SULFATEG-418 SULPHATE620u/MgUSPGradeA1720-5GGENETICIN418 DisuLG418 DisuL
Geneticin (G418 Sulfate)MFCD00058314C20H44N4O18S2G418 SolutionG418 disulfate saltG-418 disulfate saltGeneticin sulfate;G418 sulfateSCHEMBL29360851

データベース識別子

CAS
108321-42-2
PubChem CID
16218858
EC Number
600-864-4

物性

構造計算による物性

極性表面積
414 Ų
水素結合供与体数
14
水素結合受容体数
22
回転可能結合数
6
重原子数
44

物理化学的性質

貯蔵温度
2 · 2-8°C
溶解性
2 O: · H2O: 50 mg/mL
外見
白い粉
色
ホワイトからオフホワイト
由来生物
Micromonospora echinospora
水溶解度
溶ける

化学的性質

化学的特性white to off-white powder

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H315 (25%): Causes skin irritation [Warning Skin corrosion/irritation]

P203, P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P318, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 72 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Hazard Classes and CategoriesSkin Irrit. 2 (25%)

安全データ

wgk
3
rtecs
CB9378500
hs_code
29419090
risk_code
20/21/22-36/37/38-42/43
hazard_code
Xn,Xi
safety_code
22-24/25-36/37-23-36-26-45

化学と産業

応用分野 · 5 件

用途遺伝子研究の実験において、アミノグリコシド3'-ホスホトランスフェラーゼ遺伝子(ジェネティシン耐性)を選択マーカーとする場合に使用される。

用途遺伝子導入における選抜剤の抗生物質。

説明Geneticin (also known as G418, G418 sulfate) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells and is commonly used in laboratory research to select genetically engineered cells. Resistance to Geneticin is conferred by the neo gene from Tn5 encoding an aminoglycoside 3'-phosphotransferase, APH 3'II.

使用Geneticin is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL. It is also used to membrane-permeant allosteric effector of hemoglobin therapeutic in cardiovascular diseases and cancer.

一般的な説明The optimal concentration of G418 for selection of resistance will vary according to the organism and/or cell type under investigation. In general, the concentration of active drug required for selection is as follows: Dictyostelium sp.: 10-100 μg/ml Plant cells: 10-100 μg/ml Yeast cells: 0.5-1.0 μg/ml Mammalian cells: 0.1-2.0 μg/ml

サプライヤー102 社

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上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]

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