Calcitonin is a 32-membered heterodetic cyclic peptide comprising the sequence Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 cyclised by a disulfide bridge between the two Cys residues at positions 1 and 7. It has a role as a metabolite and a bone density conservation agent. It is a polypeptide, a heterodetic cyclic peptide and a peptide hormone.
Breast Feeding; Lactation; Milk, Human; Bone Density Conservation Agents; Neuropeptides; Peptide Hormones
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
融点
222 oC · >222oC (dec.)
比重(密度)
1.54 · 1.54±0.1 g/cm3(Predicted)
貯蔵温度
20 °C · −20°C
溶解性
0.05 M酢酸：1 · 0.05M酢酸：1 mg/mL 無色透明
外見
粉
色
ホワイトからオフホワイト
水溶解度
1 mg/mlで水に溶ける · 1mg/mlで水に溶ける
Merck
13 · 13,1642
InChIKey
IYTKRMFJECGBRF-LXQLIYPUSA-N
CAS データベース
47931 · 47931-85-1(CAS DataBase Reference)
化学的性質
化学的特性White or almost white powder.
安全と法規制
毒性情報
Drug Induced Liver Injury · 6 件
Drug Induced Liver Injury Rank (DILIrank 2.0)
Calcitonin salmon
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
安全データ
F
3-10
wgk
3
rtecs
EV8000000
hs_code
2937190000
safety_code
22-24/25
Hazard Classifications
Acute Tox. 3 Oral
ストレージクラス
6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
化学と産業
薬理情報
Protein BindingProtein binding is about 30 to 40%.
Pharmacodynamics · 1 件
Calcitonin inhibits bone resorption by osteoclasts (bone remodeling cells) and promotes bone formation by osteoblasts. This leads to a net increase in bone mass and a reduction in plasma calcium levels. It also promotes the renal excretion of ions such as calcium, phosphate, sodium, magnesium, and potassium by decreasing tubular reabsorption. In consequence, there is an increase in the jejunal secretion of water, sodium, potassium, and chloride.
Mechanism of Action · 1 件
Calcitonin binds to the calcitonin receptor (found primarily in osteoclasts) which then enhances the production of vitamin D producing enzymes (25-hydroxyvitamine D-24-hydroxylase), leading to greater calcium retention and enhanced bone density. Binding of calcitonin to its receptor also activates adenylyl cyclase and the phosphatidyl-inositol-calcium pathway.
Biological Half-LifeHalf-life elimination (terminal): I.M. 58 minutes; SubQ 59 to 64 minutes; Nasal: ~18 to 23 minutes
Metabolism/MetabolitesSalmon calcitonin primarily undergoes degradation in the kidneys to form pharmacologically inactive metabolites. It is also metabolized in the blood and the peripheral tissue.
FDA Pharmacological Classification · 6 件
7SFC6U2VI5
CALCITONIN SALMON
Chemical Structure [CS] - Calcitonin
Established Pharmacologic Class [EPC] - Calcitonin
Calcitonin salmon is a Calcitonin.
CALCITONIN SALMON
MeSH Pharmacological Classification · 2 件
Hormones and molecules with calcium-regulating hormone-like actions that modulate OSTEOLYSIS and other extra-skeletal activities to maintain calcium homeostasis.
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
Absorption, Distribution and Excretion · 3 件
Salmon calcitonin is rapidly absorbed with bioavailability of 71% following subcutaneous injection and 66% following intramuscular injection in humans. Via the nasal route, the bioavailability varies between 3 to 5% relative to IM.
Urine. Studies with injectable calcitonin show increases in the excretion of filtered phosphate, calcium, and sodium by decreasing their tubular reabsorption in the kidney.
0.15 to 0.3 L/kg
応用分野 · 3 件
用途カルシトニン骨吸収抑制
説明Calcitonin is a single-chain polypeptide consisting of 32 amino acid residues. Calcitonins as obtained from different species are identical at seven of the first nine residues, contain Gly at position 28, and all terminate with Pro-NH2. The C-terminal proline amide (ProNH2) is very important for the biological function of CT, as is the disulfide bridge between Cys residues at positions 1 and 7. In contrast, the residues from 10 through 27 can be varied and seem to influence CT's potency as well as its duration of action. Salmon CT differs from human CT at 16 amino acid residues.
使用Calcitonin salmon can be used for calcitonin receptor/cAMP assay for assessing the presence of calcitonin receptors expressed by TRAP+ cells.The product can also be used as a test compound for studying as well as comparing the impact of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric mucosal barrier in rats exposed to cold + restraint stress (CRS).
