Copper sulfide (CuS)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

ETHYLENEDIAMINE TETRAACETIC ACID USED AS AN INHIBITOR OF COPPER SULFIDE PRECIPITATION IN ITS REMOVAL FROM WASTEWATER.

1.0 [mg/m3], as Cu

8 hr Time Weighted Avg (TWA): 1 mg/cu m. /Copper dusts and mists, as Cu/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Copper dusts and mists, as Cu/

0.3 [mg/m3]

3.3 [mg/m3]

20 [mg/m3]

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

People must absorb small amounts of copper every day because copper is essential for good health, however, high levels of copper can be harmful. Very-high doses of copper can cause damage to your liver and kidneys, and can even cause death. Copper may induce allergic responses in sensitive individuals. (L278, L279)

Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes become saturated and copper accumulates in the nucleus, causing nuclear damage. This damage is possibly a result of oxidative damage, including lipid peroxidation. Copper inhibits the sulfhydryl group enzymes such as glucose-6-phosphate 1-dehydrogenase, glutathione reductase, and paraoxonases, which protect the cell from free oxygen radicals. It also influences gene expression and is a co-factor for oxidative enzymes such as cytochrome C oxidase and lysyl oxidase. In addition, the oxidative stress induced by copper is thought to activate acid sphingomyelinase, which lead to the production of ceramide, an apoptotic signal, as well as cause hemolytic anemia. Copper-induced emesis results from stimulation of the vagus nerve. (L277, T49, A174, L280)

THE EFFECT ON THE CHINESE HAMSTER OVARY CELLS EXPOSED TO CRYSTALLINE CUPRIC SULFIDE AT 10 UG/ML FOR 24 HR WAS INDUCTION OF DNA STRAND BREAKS.

EXPERIMENTS ON THE EFFECT OF DIFFERENT ZINC & COPPER SALTS UPON THE ACTINOMYCETALES WERE CARRIED OUT USING THE POT METHOD BASED ON INSERTION OF DIFFERENT METAL SALTS @ 7500 PPM (IN TERMS OF METAL) INTO PREPD FOREST SOIL. COPPER SULFIDE SHOWED NO TOXIC EFFECT.

The carcinogenicity of cupric oxide, cupric sulfide, and cuprous sulfide in 2 to 3 month old Wistar rats /was studied/. Groups of 30-32 rats were given single im injections containing 20 mg of cupric oxide (16 mg copper), cupric sulfide (13.3 mg copper), and cuprous sulfide (16 mg copper) into the left and the right thigh of each rat. All animals were observed for up to 20 months, after which histopathological evaluation was conducted. Controls were not reported. Of the animals receiving cupric oxide, cupric sulfide, and cuprous sulfate, the ratios of animals surviving the experiment/animals dosed were 10/32, 19/30, and 18/30, respectively. No injection site tumors were observed, and the groups of animals receiving cupric oxide, cupric sulfide, and cuprous sulfide had 0, 2 (mammary fibroadenomas and reticulocytoma), and 1 (mammary fibroadenoma), respectively.

Enhanced simian adenovirus transformation /was induced/ in Syrian hamster embryonic cells with the addition of 0.38 mM copper sulfide and to a lesser extent with copper sulfate. Single strand breaks in DNA in isolated rat hepatocytes were detected after exposure to 1.0 mM, but not 0.03 or 0.3 mM cupric sulfate. This is a false positive because cytotoxicity was greater than 30% and cell lysis would result in DNA fragmentation.

For more Non-Human Toxicity Excerpts (Complete) data for CUPRIC SULFIDE (7 total), please visit the HSDB record page.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Copper and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Start an IV with lactated Ringer's /SRP: "To keep open", minimal flow rate/. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine, hydrochloride to assist eye irrigation ... . /Copper and related compounds/