1-[1-(2-チエニル)シクロヘキシル]ピペリジン·塩酸塩
1-[1-(2-チエニル)シクロヘキシル]ピペリジン·塩酸塩 · 1-[1-(2-チエニル)シクロヘキシル]ピペリジン・塩酸塩 · GK 0 · CL-421 · Thienylcyclidine · Thienylphencyclidine · 1-[1-(2-Thienyl)cyclohexyl]piperidine Hydrochloride · 1-(1-thiophen-2-ylcyclohexyl)piperidine:hydrochloride
![1-[1-(2-チエニル)シクロヘキシル]ピペリジン·塩酸塩 の分子構造式](/img/chemical/16640802.png)
識別子と物理属性
| CAS No. | 1867-65-8 |
|---|---|
| 分子式 | C15H24ClNS |
| 平均分子量 | 285.884 g/mol |
| 単同位体質量 | 285.13179845 g/mol |
| SMILES | Cl.c1csc(C2(N3CCCCC3)CCCCC2)c1 |
| InChIKey | IIPLEZRBGQCZMF-UHFFFAOYSA-N |
| PubChem CID | 16640802 |
| EC No. | 631-590-3 |
| DTXSID | DTXSID40904770 |
| 現地名 | 1-[1-(2-チエニル)シクロヘキシル]ピペリジン·塩酸塩 |
化学・物理的性質
| 融点 | 233-236 °C |
|---|---|
| 溶解度 | DMF: 5 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 2 mg/mlEthanol: 2 mg/mlMethanol: 1 mg/ml |
| 外観・状態 | A crystalline solid |
安全性と法規制
| 危険有害性情報 | コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード H315 |
|---|
用途
説明
Tenocyclidine (TCP), known more formally as N-[1-(2-thienyl)cyclohexyl] piperidine, is an analog of phencyclidine (PCP) in which the phenyl substituent is replaced with a thiophene group. TCP is a potent antagonist of the NMDA receptor-gated ion channel (Kd = 9 nM). TCP blocks NMDA-activated excitatory postsynaptic potential in brain more potently than PCP. PCP and many analogs, including TCP, block the uptake and enhance the release of dopamine both in vitro and in vivo. TCP is regulated as a Schedule I compound in the United States. This product is intended for forensic and research applications.
使用
An analog of the hallucinogen Phencyclidine (P295500).