基本情報
- CAS
125251-66-3- 標準SMILES
Cl.Oc1ccc(CCCCNC[C@H](O)c2ccc(O)c(O)c2)cc1- InChIKey
ATBUNPBAFFCFKY-FERBBOLQSA-N- 分子式
- C18H24ClNO4
- 平均分子量
- 353.8 g/mol
- 単同位体質量
- 353.1393859
概要
Arbutamine Hydrochloride is the hydrochloride salt form of arbutamine, a synthetic catecholamine with positive chronotropic and inotropic properties, used in echocardiography and diagnostic coronary angiography. Arbutamine binds to and activates beta-1 adrenergic receptors in the myocardium, thereby increasing heart rate and increasing force of myocardial contraction. By exerting a chronotropic and inotropic effect, arbutamine mimics the cardiac stress caused by exercise that may prevent adequate tissue perfusion and oxygenation, and may provoke myocardial ischemia in patients with coronary artery disease.
名称と識別子
- 優先名称
- Arbutamine Hydrochloride
- IUPAC
- 4-[(1R)-1-hydroxy-2-[4-(4-hydroxyphenyl)butylamino]ethyl]benzene-1,2-diol;hydrochloride
- 現地名
- アルブタミン塩酸塩
- 英語名
- Arbutamine Hydrochloride
- 分子式
- C18H24ClNO4
- 分子量
- 353.84
名称と別名
Arbutamine hydrochlorideGenesaArbutamine HCl125251-66-3K0NF2CPJ7FGP-2-121-3DTXSID40154718RefChem:56704DTXCID2077209Arbutamine hydrochloride [USAN]ARBUTAMINE (Hydrochloride)4-[(1R)-1-hydroxy-2-[4-(4-hydroxyphenyl)butylamino]ethyl]benzene-1,2-diol;hydrochloride
名称をさらに表示
アルブタミン塩酸塩1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-[[4-(4-hydroxyphenyl)butyl]amino]ethyl]-, hydrochloride (1:1) (ACI)
Arbutamine hydrochloride (USAN)UNII-K0NF2CPJ7FGenesa (TN)(R)-3,4-Dihydroxy-alpha-(((4-(p-hydroxyphenyl)butyl)amino)methyl)benzyl alcohol hydrochlorideSCHEMBL40757orb1698351CHEMBL1200385ARBUTAMINE HYDROCHLORIDE [MI]
データベース識別子
- CAS
125251-66-3- PubChem CID
- 166551
- DTXSID
DTXSID40154718- ChEMBL
CHEMBL1200385- UNII
- K0NF2CPJ7F
物性
構造計算による物性
- 極性表面積
- 93 Ų
- 水素結合供与体数
- 6
- 水素結合受容体数
- 5
- 回転可能結合数
- 8
- 重原子数
- 24
- 形式電荷
- 0
- 複雑度
- 320
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
- 融点
- 55 · 55-58°
- 比旋光度
- 23 · D23 -18.5° (in ethanol)
化学と産業
薬理情報
MeSH Pharmacological Classification
Drugs that selectively bind to and activate beta-adrenergic receptors.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
上流・下流製品情報
上流原料
サプライヤー6 社
Chongqing jooe co., ltd
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