N-メチルカルバミン酸3-SEC-アミルフェニル

LC50 Japanese quail oral more than 5000 ppm in 5-day diet (8% mortality at 2236 ppm, 42% at 5000 ppm) /bux/

LC50 Ring-necked pheasants oral more than 5000 ppm in 5-day diet (no mortality to 5000 ppm) /bux/

LC50 Mallards oral more than 5000 ppm in 5-day diet (12% mortality at 1000 ppm, 38% at 5000 ppm) /bux/

LD50 Mallards oral 10.5 mg/kg, 3-4 month old females (95% confidence limit 8.84-12.5 mg/kg) /68.9%, bufencarb/

For more Ecotoxicity Values (Complete) data for M-(1-METHYLBUTYL)PHENYL METHYLCARBAMATE (10 total), please visit the HSDB record page.

TERRESTRIAL FATE: IT IS UNLIKELY THAT BUX WILL CAUSE LONG-TERM ENVIRONMENTAL CONTAMINATION.

Terrestrial fate: It is degraded fairly rapidly in soil and no carry-over would be expected from one season to the next with granules. /bufencarb/

3-(1-Methylbutyl)phenyl N-methylcarbamate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites of the enzymes. This inhibition is reversible. A cholinesterase inhibitor suppresses the action of acetylcholine esterase. Because of its essential function, chemicals that interfere with the action of acetylcholine esterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop.

As with organophosphates, the signs and symptoms are based on excessive cholinergic stimulation. Unlike organophosphate poisoning, carbamate poisonings tend to be of shorter duration because the inhibition of nervous tissue acetylcholinesterase is reversible, and carbamates are more rapidly metabolized. Muscle weakness, dizziness, sweating and slight body discomfort are commonly reported early symptoms. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Contraction of the pupils with blurred vision, incoordination, muscle twitching and slurred speech have been reported. (L795)

Symptomatology: 1. Nausea, vomiting, abdominal cramps, diarrhea & excessive salivation...sweating. 2. Lassitude & weakness. 3. Rhinorrhea and sensation of tightness in chest may occur with inhalation exposure. 4. Blurring or dimness of vision. Miosis...tearing, ciliary muscle spasm, loss of accommodation and ocular pain. None of these...signs...is dependable for diagnosis. Mydriasis may be seen... 5. Loss of muscle coordination, slurring of speech, fasciculation & twitching of muscles. 6. Difficulty in breathing, excessive secretions of saliva and of resp tract mucus, oronasal frothing, cyanosis, pulmonary rales & rhonchi, and hypertension. 7. ...jerky movements, incontinence, convulsions and coma. 8. Death...due to resp arrest of central origin, paralysis of resp muscles, intense bronchoconstriction or all three. /Carbaryl/

Four spraymen and one mixer applied 6 to 7 pump charges of bufencarb during the first day and 9 to 10 pump charges during the second day... One sprayman complained of "hunger cramps" in his stomach...the same sprayman and another one reported that they had vomited... Cholinesterase activity was depressed to about 50% of normal... During the second day one sprayman vomited while at work... His pulse rate was 52 per min and he experienced some sweating, dizziness, and pupillary change. /bufencarb/

Toxic if ingested or absorbed through the skin, it inhibits cholinesterase activity in red blood cells. /bufencarb/

Very toxic to fish. Causes a variety of teratogenic effects in chick eggs when injected into the yolk sac. /bufencarb/

/Acute oral toxicity in birds/ Ataxia, dyspnea, wing-drop, tremors, regurgitation, ptosis, and wing-beat convulsions or tetany. Signs appeared as soon as 15 min and mortalities usually occurred between 20 min and 1 hr after treatment. /bufencarb/

NITROSO DERIV OF THE TESTED METHYL CARBAMATE INSECTICIDES, INCL BUX-TEN, ARE POTENT MUTAGENS, BUT PARENT INSECTICIDES ARE NON-MUTAGENIC.

May decomp when exposed to sunlight. /bufencarb/

M-(1-METHYLBUTYL)-PHENYL METHYLCARBAMATE RAPIDLY DEGRADED IN WATER. MOST OF METABOLITES WERE PRESENT AS CONJUGATES OR OTHER POLAR METABOLITES.