基本情報
- CAS
26599-17-7- 標準SMILES
Nc1ccn([C@@H]2S[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1- InChIKey
GAKJJSAXUFZQTL-CCXZUQQUSA-N- 分子式
- C9H13N3O4S
- 平均分子量
- 259.28 g/mol
- 単同位体質量
- 259.06267708
概要
OSI-7836 is a member of the nucleoside class of cytotoxic drugs of which gemcitabine is the market leader. OSI Pharmaceuticals develops OSI-7836 as a next-generation gemcitabine. The anti-tumor activity of OSI-7836 appeares to be less schedule dependent than gemcitabine. It is also more active than ara-C (another clinically used nucleoside analog) in all nine models and more active than either paclitaxel or cisplatin in the two lung xenograft models tested. This drug shows no unexpected toxicities; those observed appeared to be similar to other nucleoside agents.
名称と識別子
- 優先名称
- Thiarabine
- IUPAC
- 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-one
- 英語名
- THIARABINE
- 分子式
- C9H13N3O4S
- 分子量
- 259.28
名称と別名
THIARABINE26599-17-7Thio-Cytarabine4'-ThioaracytidineOSI-7836YCO2764D5Z2(1H)-Pyrimidinone, 4-amino-1-(4-thio-beta-D-arabinofuranosyl)-4'-thio-arabinofuranosylcytosine4-Amino-1-(4-thio-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone4-thio-araCRefChem:189268GS7836
名称をさらに表示
4'-thioarabinoCytidineOSI-7836 (4'-thio-araC, T-araC)4-Amino-1-(4-thio-β-D-arabinofuranosyl)-2(1H)-pyrimidinone2(1H)-Pyrimidinone, 4-amino-1-(4-thio-β-D-arabinofuranosyl)-4-Amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl)pyrimidin-2(1H)-one
4'-THIO-1-BETA-D-ARABINOFURANOSYLCYTOSINE4-amino-1-((2R,3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl)-1,2-dihydropyrimidine-2-thione hydrochlorideUNII-YCO2764D5Z4'-Thio-ara-C4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-oneOSI 7836THIARABINE [WHO-DD]4'-Thio-1- beta-D-arabinofuranosylcytosine
データベース識別子
- CAS
26599-17-7
物性
構造計算による物性
- XLogP
- -1.3
- 極性表面積
- 145 Ų
- 水素結合供与体数
- 4
- 水素結合受容体数
- 5
- 回転可能結合数
- 2
- 重原子数
- 17
- 形式電荷
- 0
- 複雑度
- 386
物理化学的性質
- 沸点
- 535 · 535.0±60.0 °C(Predicted)
- 比重(密度)
- 1.9 · 1.90±0.1 g/cm3(Predicted)
- 貯蔵温度
- -20 °C · Store at -20°C
- 溶解性
- Soluble in DMSO
- 外見
- Solid
- 酸解離定数(Pka)
- 13.41 · 13.41±0.70(Predicted)
- 色
- White to off-white
化学と産業
薬理情報
Mechanism of Action
OSI-7836 appears to have a different mechanism of tumor growth inhibition blocking the cell division cycle at a different point (the G2 phase) than gemcitabine. The mechanism of action involves phosphorylation to the triphosphate form followed by incorporation into cellular DNA, leading to cell death.
サプライヤー15 社
成都彼样生物科技有限公司18108052721 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
上海迪凯蒙生物医药科技有限公司15901859516 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
杭州六可生物科技有限公司+86-0571-86912261 +86-15658003402 · [email protected]
杭州六可生物科技有限公司+86-571-86912261 19975279805 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
斯派螺（武汉）药物研发有限公司[email protected]
上海昂提生物科技有限公司13764913901 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
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