10-メチルベンズ[A]アントラセン標準液

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Product: Offer surplus and non-recyclable solutions to a licensed disposal company; Contaminated packaging: Dispose of as unused product.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Precautions for safe handling: Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.

Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

For more Preventive Measures (Complete) data for 10-Methylbenz(a)anthracene (8 total), please visit the HSDB record page.

8 Hr Time Weighted Avg (TWA): 0.2 mg/cu m. /Coal tar pitch volatiles, as benzene soluble aerosol/

Peak Exposure Recommendation: Transient increases in workers' exposure levels may exceed 3 times the value of the TLV-TWA level for no more than 15 minutes at a time, on no more than 4 occasions spaced 1 hour apart during a workday, and under no circumstances should they exceed 5 times the value of the TLV-TWA level. In addition, the 8-hour TWA is not to be exceeded for an 8-hour work period. /Coal tar pitch volatiles, as benzene soluble aerosol/

A1; Confirmed human carcinogen. /Coal tar pitch volatiles, as benzene soluble aerosol/

Biological Exposure Index (BEI): Determinant: 1-Hydroxypyrene (1-HP) in urine (with hydrolysis); Sampling Time: end of shift at end of workweek. BEI: None.; Biological monitoring should be considered for this compound based on the review; however, a specific BEI could not be determined due to insufficient data. /Polycyclic aromatic hydrocarbons/

For more Threshold Limit Values (TLV) (Complete) data for 10-Methylbenz(a)anthracene (6 total), please visit the HSDB record page.

Eye/face protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves.

Body Protection: Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place.

Respiratory protection: Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

For more Personal Protective Equipment (PPE) (Complete) data for 10-Methylbenz(a)anthracene (6 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 3.0X10+5(SRC), determined from a structure estimation method(2), indicates that 10-methylbenz(a)anthracene is expected to be immobile in soil(SRC). Volatilization of 10-methylbenz(a)anthracene from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.9X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(3). However, adsorption to soil is expected to attenuate volatilization(SRC). 10-Methylbenz(a)anthracene is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.0X10-7 mm Hg at 25deg C(SRC), determined from a fragment constant method(2). 10-Methylbenz(a)anthracene was resistant to biodegradation using activated sludge in the Warburg test(4), suggesting that biodegradation is not expected to be an important fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 3.0X10+5(SRC), determined from a structure estimation method(2), indicates that 10-methylbenz(a)anthracene is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.9X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 30 and 220 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The volatilization half-life from a model pond is about 860 years when adsorption is considered(5). According to a classification scheme(6), an estimated BCF of 4700(SRC), from an estimated log Kow of 6.07(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is very high, provided the compound is not metabolized by the organism(SRC). 10-Methylbenz(a)anthracene was resistant to biodegradation using activated sludge in the Warburg test(7), suggesting that biodegradation is not expected to be an important fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 10-methylbenz(a)anthracene, which has an estimated vapor pressure of 1.0X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases. Vapor-phase 10-methylbenz(a)anthracene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 0.08 days(SRC), calculated from its rate constant of 1.3X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase 10-methylbenz(a)anthracene may be removed from the air by wet and dry deposition(SRC). 10-Methylbenz(a)anthracene absorbs UV light at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

IDENTIFICATION AND USE: 10-Methylbenz(a)anthracene (10-MBA) is a solid. It could be formed from incomplete combustion of organic materials. It is used mostly in biochemical research. HUMAN EXPOSURE AND TOXICITY: There are no data available. ANIMAL STUDIES: Mice received dermal applications of 10-MBA, 300 ug/application, twice a week for 20 weeks. 72% of mice had dose-action related palillomas. There appeared to be little quantitative correspondence between carcinogenic and mutagenic potency for this group of chemicals.

Methylbenz(a)anthracenes, including 10-methylbenz(a)anthracene, were reported at a concentration range of 30-50 ng/mg extract in diesel engine exhaust of passenger cars(1). Methylbenz(a)anthracenes are found in airborne particulates from cigarette smoke condensate, stack gases, roofing tar extracts, and industrial effluents(2).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 10-methylbenz(a)anthracene can be estimated to be 3.0X10+5(SRC). According to a classification scheme(2), this estimated Koc value suggests that 10-methylbenz(a)anthracene is expected to be immobile in soil(SRC).

10-Methylbenz(a)anthracene is one of many polycyclic aromatic hydrocarbons (PAH), a group of chemicals that are formed during the incomplete burning of coal, oil, gas, wood, garbage, or other organic substances. PAHs generally occur as complex mixtures, for example as part of combustion products such as soot, not as single compounds. PAHs occur naturally in volcanoes and forest fires. They can also be found in substances such as crude oil and coal. They are found throughout the environment in the air, water, and soil(1). /Polycyclic aromatic hydrocarbons/

Methylbenz(a)anthracenes are found in airborne particulates from cigarette smoke condensate, stack gases, roofing tar extracts and industrial effluents(1), which may result in 10-methylbenz(a)anthracene's release to the environment through various waste streams(SRC). There is no commercial production of this compound(2).

AEROBIC: In Warburg respirometer tests, 10-methylbenz(a)anthracene, present at a concentration of 500 mg/L, was resistant to biodegradation by activated sludge from three different treatment plants(1). 10-Methylbenz(a)anthracene reached 3.1% of its theoretical oxygen demand over a period 144 hours using activated sludge from a treatment plant receiving municipal waste(1). 10-Methylbenz(a)anthracene was toxic to activated sludge obtained from a treatment plant receiving combined domestic wastewater(1). 10-Methylbenz(a)anthracene reached 0.4% of its theoretical oxygen demand over a period of 144 hours using activated sludge from a treatment plant receiving residential wastes only(1).

PURE CULTURE: Methylbenz(a)anthracenes were found to be biodegraded by the soil fungus Cunninghamella elegans to 3,4-diols(1). /Methylbenz(a)anthracenes/

An estimated BCF of 4700 was calculated in fish for 10-methylbenz(a)anthracene(SRC), using an estimated log Kow of 6.07(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is very high, provided the compound is not metabolized by the organism(SRC). However, bioconcentration studies on compounds which are structurally similar suggest that bioconcentration may be lower than that indicated by the regression-derived equations due to the ability of some aquatic organisms to readily metabolize this polycyclic aromatic hydrocarbons of compounds(3).

The Henry's Law constant for 10-methylbenz(a)anthracene is estimated as 1.9X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 10-methylbenz(a)anthracene is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 30 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 220 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The volatilization half-life from a model pond is about 860 years when adsorption is considered(3). 10-Methylbenz(a)anthracene's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 10-Methylbenz(a)anthracene is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.0X10-7 mm Hg(SRC), determined from a fragment constant method(4).

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ /Mice received dermal applications of 10-methylbenz(a)anthracene, 300 ug/application, twice a week for 20 weeks. 72% of mice had dose-action related papillomas./ /From table/

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ The specificity of in-vitro transformation of normal embryonic cells exposed to carcinogenic hydrocarbons was investigated in hamsters and mice. Golden-hamster or SWR-mice embryos were minced and cell suspensions inoculated onto irradiated dishes containing rat embryo feeder layers. Cells for cloning were seeded for 7 to 10 days. Cultures were examined microscopically. Compounds tested were applied on cell cultures by millipore disc filters or by colloidal suspension in growth medium. Transformed cultures were trypsinized and inoculated subcutaneously into adult animals. Tumors were palpated during development, then removed and examined histologically. The transformed cells displayed a hereditary random pattern of growth, ability to grow continuously, and were resistant to benz(a)pyrene (50328) (BP) when tested in culture. Transformed cells in culture were obtained with 3-methylcholanthrene (56495) (MCA), 7,12-dimethylbenzo(a)anthracene (57976) and 10-methylbenz(a)anthracene (2381159), in-vivo, but not with 8-methylbenz(a)anthracene (2381319), chrysene (218019), and pyrene (129000). Carcinogenic hydrocarbons induced direct transformation of normal cells to tumor cells in-vitro. Fibroblasts and epithelial type cells were found with high frequency during transformation in culture. BP induced 25.6 percent transformation of clones, 1 to 2 days after addition of the carcinogen. BP and MCA produced transformed cells, which were not found in cultures of untreated controls. After long periods in culture both untreated and treated mouse cells grew progressively as tumors after inoculation into adult SWR-mice. The authors conclude that expression of transformation is dependent on cell division.

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity: Initiation-Promotion/ The 12 possible monomethylbenz[a]anthracenes (MBAs) were examined for their tumor-initiating activity in the classical two-stage initiation-promotion experiment. Based on the average number of tumors/mouse, 7-MBA was the most tumorigenic compound of the series causing 4.9 papillomas/mouse at an initiating dose of 400 nmol/mouse. At this same dose level 8-MBA and 12-MBA were equally potent causing 1.0 papillomas/mouse. 6- an 9-MBAs caused approximately 0.6 papillomas/mouse at this dose level. These data are in general agreement with previous experiments using other model systems. Of interest is the low tumorigenicity of the 1-, 2-, 3-and 4-MBAs which has been cited in support of the bay region theory of polycyclic aromatic hydrocarbon carcinogenesis. ... /Monomethylbenz(a)anthracenes/

/GENOTOXICITY/ The 12 isomeric monomethylbenz(a)anthracenes, 7,12-dimethylbenz(a)anthracene and benz(a)anthracene show a wide range of carcinogenicities. These compounds were investigated for mutagenicity with Samonella typhimurium TA 100 using postmitochondrial liver fraction from control mice or mice treated with different enzyme inducers and an NADPH-generating system (S-9 mix) for metabolic activation. The effect of epoxide hydrolase and dihydrodiol dehydrogenase on the activation was studied. All 14 compounds were mutagenic, the potency at optimal conditions varying from 3-35 revertants/nmol. Some compounds were readily activated by preparations from control animals, while with others a marked activation was only found with preparations from treated animals. All were readily activated by S-9 mix from Aroclor-1254-treated mice. With some compounds, a similarly clear effect was obtained by pretreatment with 3-methylcholanthrene; phenobarbital pretreatment did not significantly improve the activation. With other compounds the reverse was the case. Addition of pure epoxide hydrolase did not affect the mutagenicity of 7,12-dimethylbenz(a)anthracene. It increased the mutagenicity of 5- and 6-methylbenz(a)anthracene, which carry the methyl group at the K-region, 2- and 3-fold, respectively. The mutagenicity of the 11 other compounds was reduced 16-94%. Dihydrodiol dehydrogenase decreased the mutagenicity of the strong carcinogens 7-methylbenz(a)anthracene, 12-methylbenz(a)anthracene and 7,12-dimethylbenz(a)anthracene by 15-41%. With the other compounds, the effects were weaker and not statistically significant. In spite of similar chemical structures and physicochemical properties, the mutagenicity of the benz(a)anthracenes investigated in the mammalian enzyme-mediated Salmonella test is affected very differently by the same modifications of the metabolizing system. The relative mutagenic potencies, therefore, strongly depend on the system. None of the different activating systems used in the mammalian enzyme-mediated Salmonella test gave a good quantitative correlation of mutagenicity with carcinogenicity. /Monomethylbenz(a)anthracenes/

The rate constant for the vapor-phase reaction of 10-methylbenz(a)anthracene with photochemically-produced hydroxyl radicals has been estimated as 1.3X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 0.08 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 10-Methylbenz(a)anthracene is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 10-Methylbenz(a)anthracene absorbs UV light at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

Occupational exposure to 10-methylbenz(a)anthracene may occur through inhalation of dust particles contaminated with incomplete combustion products and dermal contact with incomplete combustion products containing 10-methylbenz(a)anthracene. The most likely pathway by which the general public is exposed to 10-methylbenz(a)anthracene is by inhalation due to the probable release of this substance from combustion fuels and cigarette smoke. (SRC)

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Polynuclear aromatic hydrocarbons (including benzanthracenes, benzopyrenes, benzofluoranthene, chrysenes, dibenz-anthracenes, and indenopyrenes)/

For the maximum protection of human health from the potential carcinogenic effects of exposure to polynuclear aromatic hydrocarbons through ingestion of contaminated water and contaminated aquatic organisms, the ambient water concentration should be zero, based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, and 1X10-7. The corresponding recommended criteria are 28.0 ng/L, 2.8 ng/L, and 0.28 ng/L, respectively. If these estimates are made for consumption of aquatic organisms only, excluding consumption of water, the levels are 311.0 ng/L, 31.1 ng/L, and 3.11 ng/L, respectively. /Polynuclear aromatic hydrocarbons/.