2,6-ジクロロピリジン

2,6-Dichloropyridine

HCID 16989CAS 2402-78-0
部分構造検索類似構造を探す

基本情報

標準SMILES
Clc1cccc(Cl)n1
InChIKey
FILKGCRCWDMBKA-UHFFFAOYSA-N
分子式
C5H3Cl2N
平均分子量
147.99 g/mol
単同位体質量
146.9642545

名称と識別子

優先名称
2,6-Dichloropyridine
IUPAC
2,6-dichloropyridine
現地名
2,6-ジクロロピリジン
英語名
2,6-Dichloropyridine
分子式
C5H3Cl2N
分子量
147.99

名称と別名

2,6-DICHLOROPYRIDINE2402-78-0Pyridine, 2,6-dichloro-DTXSID2051895WM26PC2SBWNSC-76606DTXCID0030457RefChem:83196219-282-3MFCD000062442,6-Dichloro-pyridine2,6-Dichloropyridine, 98%
名称をさらに表示
2,6-ジクロロピリジン2,6-ジクロロピリジン 塩化物２，６ジクロロピリジン2,6‐ジクロロピリジン2,6-ジクロロピリジン, 98%26DCLPYAURORA KA-64952,6-DichLoropyridineAKOS BBS-000043142,6-Dichloropyridinr2,6-dichloro-pyridinTrazodone Impurity 30
CCRIS 1727EINECS 219-282-3NSC 76606BRN 0108664NSC766062,6-dichlorpyridine2.6-dichloropyridineUNII-WM26PC2SBW

データベース識別子

CAS
2402-78-0
PubChem CID
16989
DTXSID
DTXSID2051895
ChEMBL
CHEMBL3561947
UNII
WM26PC2SBW
EC Number
219-282-3
Nikkaji
J51.304K

物性

構造計算による物性

XLogP
2.2
極性表面積
12.9 Ų
水素結合供与体数
0
水素結合受容体数
1
回転可能結合数
0
重原子数
8

実験および物理化学的性質

Physical Description · 2 件

Wet Solid

White crystalline solid; [Alfa Aesar MSDS]

物理化学的性質

融点
83 · 83-86 °C (lit.)
沸点
211 °C · 211 °C
比重(密度)
1.5159 · 1.5159 (rough estimate)
屈折率
1.55 · 1.5500 (estimate)
闪点
110 °C · 110°C
貯蔵温度
2 · Inert atmosphere,2-8°C

化学的性質

化学的特性White to light yellow solid

安全と法規制

GHS分類

GHS Classification · 5 件

Danger

H301 (96.6%): Toxic if swallowed [Danger Acute toxicity, oral]；H315 (15.5%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (15.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (12.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 58 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 2 件

Pyridine, 2,6-dichloro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Pyridine, 2,6-dichloro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Pyridine, 2,6-dichloro-: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryCauses somnolence and fatty liver degeneration in intraperitoneal lethal-dose studies of mice; [RTECS] An irritant; Toxic by ingestion; [Alfa Aesar MSDS] See Pyridine.
Hazard Classes and CategoriesAcute Tox. 3 (96.6%)；Skin Irrit. 2 (15.5%)；Eye Irrit. 2A (15.5%)；STOT SE 3 (12.1%)

毒性情報

Adverse EffectsNeurotoxin - Other CNS neurotoxin；Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

法規制情報

Regulatory Information · 2 件

Pyridine, 2,6-dichloro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Pyridine, 2,6-dichloro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Pyridine, 2,6-dichloro-: Does not have an individual approval but may be used under an appropriate group standard

安全データ

wgk
3
tsca
TSCA listed
rtecs
US8400000
ridadr
UN 2811 6.1/PG 2
毒性
mouse,LD50,intraperitoneal,115mg/kg (115mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LIVER: FATTY LIVER DEGERATIONBEHAVIORAL: ANTIPSYCHOTIC,Toxicology and Applied Pharmacology. Vol. 11, Pg. 361, 1967.
hs_code
29333999

化学と産業

用途と製造

U.S. Production2023: 53,953 lb；2022: 186,928 lb；2021: 226,252 lb；2020: 232,841 lb
Industry UsesIntermediate
General Manufacturing Information · 2 件

Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing

Pyridine, 2,6-dichloro-: ACTIVE

応用分野 · 3 件

用途有機合成原料(医薬、農薬)。

説明2,6-Dichloropyridine is an important intermediate that is widely used in the medicine and pesticide research field. It could be used as a starting material to synthesize the pirozadil (Pirozadil) which can be used for reducing blood-fat, and antiplatelet condensation. 2,6-dichloropyridine also can be used to synthetic musk pyridine with alternative natural musk. 2,3,5, 6-TCP produced by further chlorination of 2, 6-dichloropyridine is an important raw material for chlorpyrifos, which is widely used in the world with high efficiency, broad spectrum, and low residue.

使用2,6-Dichloropyridine is used in the preparation of triazolo and imidazo potassium channel antagonists as antiarrythmic agents.

調製方法

純化方法It crystallises from EtOH. [Beilstein 20/5 V 416.]

上流・下流製品情報

サプライヤー50 社

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
山东艾利特生物科技有限公司0539-18853986-090 13053958157 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]

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