4-ヒドロキシ-3-メトキシフェニル酢酸
Homovanillic Acid
データを補完しています。しばらくしてからページを更新すると最新の内容を表示できます
基本情報
- CAS
306-08-1- 標準SMILES
COc1cc(CC(=O)O)ccc1O- InChIKey
QRMZSPFSDQBLIX-UHFFFAOYSA-N- 分子式
- C9H10O4
- 平均分子量
- 182.17 g/mol
- 単同位体質量
- 182.0579088
概要
Homovanillic acid is a monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite. It has a role as a mouse metabolite and a human metabolite. It is a member of guaiacols and a monocarboxylic acid. It is functionally related to a (3,4-dihydroxyphenyl)acetic acid. It is a conjugate acid of a homovanillate.
名称と識別子
- 優先名称
- Homovanillic Acid
- IUPAC
- 2-(4-hydroxy-3-methoxyphenyl)acetic acid
- 現地名
- 4-ヒドロキシ-3-メトキシフェニル酢酸
- 英語名
- Homovanillic acid
- 分子式
- C9H10O4
- 分子量
- 182.17
名称と別名
Homovanillic acid306-08-14-Hydroxy-3-methoxyphenylacetic acid2-(4-hydroxy-3-methoxyphenyl)acetic acidBenzeneacetic acid, 4-hydroxy-3-methoxy-Vanillacetic acid3-Methoxy-4-hydroxyphenylacetic acid4-Hydroxy-3-methoxybenzeneacetic acid(4-HYDROXY-3-METHOXYPHENYL)ACETIC ACIDAcetic acid, (4-hydroxy-3-methoxyphenyl)-X77S6GMS36DTXSID5059791
名称をさらに表示
4-ヒドロキシ-3-メトキシフェニル酢酸3-メトキシ-4-ヒドロキシベンゼン酢酸3-メトキシ-4-ヒドロキシフェニル酢酸4-ヒドロキシ-3-メトキシベンゼン-1-酢酸4-ヒドロキシ-3-メトキシベンゼン酢酸グアイアシル酢酸(4-ヒドロキシ-3-メトキシフェニル)酢酸ホモバニリン酸(3-メトキシ-4-ヒドロキシフェニル)酢酸ホモバニリン酸, 98+%HVAHomovanilic acidJACS-306-08-1homovanillicaciVanilacetic acidHOMOVANIUIC ACID
HMDB00118NSC-16682CHEBI:545959Acid, Homovanillic3 Methoxy 4 Hydroxyphenylacetic Acid4 Hydroxy 3 Methoxyphenylacetic AcidAcid, 3-Methoxy-4-HydroxyphenylaceticAcid, 4-Hydroxy-3-Methoxyphenylacetic
物性
構造計算による物性補完中
- XLogP
- 0.4
- 極性表面積
- 66.8 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 4
- 回転可能結合数
- 3
- 重原子数
- 13
- 形式電荷
- 0
- 複雑度
- 180
実験および物理化学的性質
Chemical ClassesBiological Agents -> Other Biomolecules
LogP
0.33
1.18
Solubility17 mg/mL
Melting Point138 - 140 °C
Vapor Pressure0.00000823 [mmHg]
Physical Description
White solid; [Merck Index] White to pale brown crystalline powder; [Alfa Aesar MSDS]
Solid
Collision Cross Section
134.15 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
140.75 Ų [M-H]- [CCS Type: DT; Method: stepped-field]
146.2 Ų [M+Na]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
136.3 Ų [M-H]-
物理化学的性質
- 融点
- 142 · 142-145 °C(lit.)
- 沸点
- 235.56 °C · 235.56°C (rough estimate)
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 46 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory InformationBenzeneacetic acid, 4-hydroxy-3-methoxy-: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryA skin, respiratory tract, and strong eye irritant; [Alfa Aesar MSDS]
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
安全データ
- F
- 10-23
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 29189900
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- hazard_class
- IRRITANT
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
Tissue LocationsBrain
Cellular LocationsCytoplasm
Metabolite PathwaysAlkaptonuria
用途と製造
UsesA metabolite present in human urine; [Merck Index]
General Manufacturing InformationBenzeneacetic acid, 4-hydroxy-3-methoxy-: ACTIVE
応用分野
用途有機合成原料、ホモバニリン酸の試験研究用。
説明Homovanillic acid (HVA) is a dopamine metabolite. It is formed via deamination of dopamine by monoamine oxidase (MAO) to produce 3,4-dihydroxyphenylacetic acid (DOPAC; ) followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively. It has been used to quantify hydrogen peroxide production in macrophages and neutrophils.
使用Fluorimetric reagent and major catecholamine metaboliteHomovanillic acid is used as a reagent in the determination of oxidative enzymes. It is associated with dopamine levels in the brain. Its presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma.
上流・下流製品情報
上流原料
関連反応
32 件
化合物ノート
読み込み中…