5-エトキシ-3-トリクロロメチル-1,2,4-チアジアゾール

Extinguishing media, suitable: Large fires: alcohol-type foam or universal-type foams; Small fires: CO2, dry chemical, water spray. /Terrazole 35WP/

Extinguishing media, unsuitable: water jets. /Terrazole 35WP/

Body covering protective clothing, full "turn-out" gear. Self-contained breathing apparatus. /Terrazole 35WP/

Do not discharge extinguishing waters into streams, rivers and lakes. /Terrazole 35WP/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Container Disposal: Paper Bags: Nonrefi llable container. Do not reuse or refi ll this container. Offer for recycling, if available. Completely empty into application equipment. Then dispose of empty bag in a sanitary landfi ll, or by incineration, or if allowed by State and local authorities, by burning. If burned, stay out of smoke. /Terrazole 35% Wettable Powder/

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Avoid contact with skin, eyes, or clothing. Avoid breathing dusts or spray mist. Wash thoroughly with soap and water after use and before eating or smoking. Remove contaminated clothing and wash before reuse.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR 170. /Terrazole 35% Wettable Powder/

Do not apply directly to water, to areas where surface water is present or to intertidal areas below the mean high water mark. /Terrazole 35% Wettable Powder/

For more Preventive Measures (Complete) data for Etridiazole (10 total), please visit the HSDB record page.

Approved respirator. Chemical-resistant gloves. Long-sleeved shirt and long pants. Protective eyewear.

All mixers, loaders, applicators and other handlers must wear: coveralls over long-sleeved shirt and long pants, chemical resistant gloves made of any waterproof material, chemical resistant footwear plus socks, NIOSH approved respirator with: an organic-vapor removing cartridge with a prefi lter approved for pesticides (MSHA/NIOSH approval number prefi x TC-23C), or a canister approved for pesticides (MSHA/NIOSH approval number prefi x TC-14G), or a NIOSH approved respirator with an OV cartridge or canister with any N2, R, P or HE prefi lter, chemical-resistant apron when mixing, loading, cleaning equipment. /Terrazole 35% Wettable Powder/

/Restricted entry interval (REI) of 12 hours/ PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water, is: long-sleeved shirt and long pants; chemical-resistant gloves made of any waterproof material; shoes and socks; protective eyewear. /Terrazole 35% Wettable Powder/

The estimated total body accumulation rate for etridiazole determined during controlled sprayings was 3,200 (+/-2,500) ug/hr with a normalized accumulation rate of 28 mg per kg pesticide sprayed(1). The estimated total body accumulation rate for etridiazole for greenhouse sprayings was 1,233 ug/hr with a normalized accumulation rate of 49 mg per kg pesticide sprayed(2,3). The average concentration of etridiazole in six pesticide workers' saliva was 86-4,130 ppb while the average metabolites concentration in their urine was 0.30-7.00 ppm(4).

LC50; Species: Colinus virginianus (Northern Bobwhite Quail) diet >5000 ppm for 8 days

LC50; Species: Anas platyrhynchos (Mallard Duck) diet 1650 ppm for 8 days

LD50; Species: Colinus virginianus (Northern Bobwhite Quail) age 21 wk; oral via capsule 560 mg/kg

LD50; Species: Anas platyrhynchos (Mallard Duck) oral via capsule 1640 mg/kg

For more Ecotoxicity Values (Complete) data for Etridiazole (15 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 349 in sand loam and 323 in silt loam(2), indicate that etridiazole is expected to have moderate mobility in soil(SRC). Volatilization of etridiazole from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole(SRC), based upon its vapor pressure, 0.011 mm Hg(2), and water solubility, 117 mg/L(2). Etridiazole is somewhat susceptible to soil photolysis(3). Etridiazole is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). The half-life of etridiazole in a silt loam at 25 °C was 9.5 days under aerobic conditions and 3 days under anaerobic conditions(2), suggesting that biodegradation will be an important fate process in soil(SRC). A reported degradation product, 3-dichloromethyl-5-ethoxy-1,2,4-thiadiazole, was observed in soil photolysis and aerobic soil metabolism studies(3). Two terrestrial field dissipation studies of etridiazole were reported with half-lives of 16 and 33 days(3). The variability in half-lives (4-33 days) seen in terrestrial field dissipation studies conducted in Texas, North Carolina and Califonia is consistent for compounds that volatilize(3).

AQUATIC FATE: Based on a classification scheme(1), Koc values of 349 in sand loam and 323 in silt loam(2), indicate that etridiazole is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 0.011 mm Hg(2), and water solubility, 117 mg/L(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.0 and 20 days, respectively(SRC). According to a classification scheme(4), BCFs of 94 to 328 measured in fish(5,6), suggest bioconcentration in aquatic organisms is high(SRC). Half-lives of 3 to 9.5 days in soils(2) suggest that biodegradation may be an important fate process in water. The hydrolysis half-life of etridiazole was measured as 103 days at pH 6 and 25 °C, and 12 days at pH 6 and 45 °C(2). Etridiazole is also stable to aqueous photolysis and may persist for considerable periods of time in aquatic areas with long residence times and low microbiological activity(6).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), etridiazole, which has a vapor pressure of 0.011 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase etridiazole is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.3 days(SRC), calculated from its rate constant of 6.9X10-12 cu cm/molecule-sec at 25 °C(SRC), that was derived using a structure estimation method(3). Etridiazole does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

/BIRDS and MAMMALS/ In acute oral toxicity to mallard ducks, the signs of intoxication were: sitting, polydipsia, ataxia, slowness, hyporeactivity, stumbling, asthenia, and myasthenia. Signs appeared as soon as 25 min and the single mortality occurred between 3 and 7 days after treatment. Remission took up to 16 days.

/BIRDS and MAMMALS/ In a chronic toxicity study in mallards, significant reproductive effects including reduced numbers of eggs laid, viable embryos, normal hatchlings and 14-day survivors were observed. A chronic toxicity study in bobwhite quail yielded similar results. It is uncertain whether these reproductive effects are indicative of an endocrine-mediated mode of action.

/AQUATIC SPECIES/ Etridiazole was classified as highly toxic to non-target aquatic plants. Toxicity to green algae was approximately 100 times higher than other aquatic plants tested. Acute risk concerns exist at the typical application rates for turf... .

SOURCE DOMINATED: The atmospheric concentration of etridiazole determined during controlled sprayings was 0.002 ug/L with a normalized deposition rate on the air sampler of 0.1402 mg/kg sprayed(1). The atmospheric concentration of etridiazole determined during greenhouse sprayings was 0.085 ug/L with a normalized deposition rate on the air sampler of 0.1402 mg/kg sprayed(2,3).

The Agency has previously identified and required the submission of the generic (i.e., active ingredient-specific) data required to support reregistration of products containing etridiazole as an active ingredient. The Agency has completed its review of these generic data, and has determined that the data are sufficient to support reregistration of all products containing etridiazole. Appendix B identifies the generic data requirements that the Agency reviewed as part of its determination of reregistration eligibility of etridiazole. These data were sufficient to allow the Agency to determine that etridiazole can be used without resulting in unreasonable adverse effects to humans and the environment. The Agency, therefore, finds that all products containing etridiazole as the active ingredient are eligible for reregistration, provided specified changes are made to the label. ... The Agency believes that these label changes address the current risk estimates and reflect the use of all acceptable data available at this time together with uncertainty factors and where data gaps exist.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Etridiazole is found on List A, which contains most pesticides that are used on foods and, hence, have a high potential for human exposure. List A consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0009; Pesticide type: fungicide; Registration Standard Date: 09/01/80; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): etridiazole; Data Call-in (DCI) Date(s): 06/24/92, 02/18/93, 10/13/95; AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.