N-[(ジエトキシチオホスフィノイルチオ)アセチル]-N-メチルカルバミド酸エチル

Refer immediately for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.

Rinse with plenty of water (remove contact lenses if easily possible).

Rinse mouth. Refer immediately for medical attention.

Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, liquid, NOS/

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, solid, NOS/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

In some situations where personnel may become accidently contaminated ... it is necessary to provide shower bath in addition to the usual washing facilities. Special arrangements for cleaning clothing & overalls may be necessary ... . /Pesticides/

Special aircraft should preferably be used for spraying or dusting toxic organophosphorus pesticides. ... Aerial spraying or dusting gives rise to clouds which spread over larger surfaces than clouds produced by ground application. Aerial spraying should therefore be carried out on windless days only. Residential areas, water supply sources, etc must be avoided. ... When aircraft approaches, signalmen /guiding the aircraft/ should leave the windward side. ... The local population should be informed about the site & time of aerial pesticide treatment. Access of unauthorized persons & especially children to the area to be treated must be ... forbidden. Warning signs should be placed at the limits of the area. Ground spraying must be carried out with compressed-air spraying equipment towed by tractors with closed cabs. /Organophosphorus pesticides/

Small packages of pesticides are preferable for individual application in order to limit the quantities to be weighed & metered. A special vessel with long stirring rod for dilution & suspension of the poison must be available in order to reduce manual handling to a minimum. The strict observance of hygiene rules--no smoking & no food intake during work. Thorough washing with soap after work, changing protective clothing before going home--is of utmost importance. /Organophosphorus pesticides/

Containers ... should be cleaned with a suspension of bleaching powder in water or with other alkaline soln after soaking for 24 hr and then be rinsed with hot water. /Organophosphorus pesticides/

For more Preventive Measures (Complete) data for MECARBAM (8 total), please visit the HSDB record page.

AT RECOMMENDED RATES OF USE IT PERSISTS IN SOIL FOR 4-6 WEEKS.

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 420(SRC), determined from an estimated log Kow(2,SRC) and a recommended regression-derived equation(3), suggests that mecarbam will have moderate mobility in soil(SRC). Mecarbam added to a loam soil in a closed system had a half-life of 77 days(4); when added to field sites, an average half-life of 13 days was reported during June-July(4). Degradation was considerably slower from August through October(4). Both biodegradation and hydrolysis are expected to contribute to mecarbam's degradation in soil(SRC). Mecarbam may hydrolyze slowly in moist soil; a half-life of 5.9 hours was measured for mecarbam at 70 °C in an ethanol-pH 6.0 buffer solution (20:80)(5). At 20 °C this rate should be several hundred times slower(5). Volatilization of mecarbam should not be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 9.0X10-10 atm-cu m/mole(6,SRC), but may be important from dry soil surfaces(SRC) based on an estimated vapor pressure of 1.3 mm Hg(7,SRC).

AQUATIC FATE: If released to water, mecarbam may hydrolyze slowly; a half-life of 5.9 hours was measured for this compound at 70 °C in an ethanol-pH 6.0 buffer solution (20:80)(1). At 20 °C this rate should be several hundred times slower(1). Based on field studies in soil, biodegradation may also be an important fate process. In field studies, this compound had a half-life of 13 days in soil(2). Based on a recommended classification scheme(3), an estimated Koc value of 420(SRC), determined from an estimated log Kow(4,SRC) and a recommended regression-derived equation(5), indicates that mecarbam should not adsorb to suspended solids and sediment(SRC) in the water. Mecarbam will not volatilize from water surfaces based on an estimated Henry's Law constant of 9.0X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(6). According to a classification scheme(7), an estimated BCF value of 32(5,SRC), from an estimated log Kow(4,SRC), suggests that bioconcentration in aquatic organisms is moderate, not high(SRC) .

ATMOSPHERIC FATE: According to a suggested classification scheme(1), an estimated vapor pressure of 1.3 mm Hg at 25 °C(2,SRC) indicates that mecarbam will exist mainly in the vapor phase in the ambient atmosphere. Vapor-phase mecarbam is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 3 hours(3,SRC).

COMPARISON OF DISAPPEARANCE OF 8 ORGANOPHOSPHORUS INSECTICIDES FROM SOIL IN LAB & IN OUTDOOR EXPERIMENTS USING GAS CHROMATOGRAPHY: MECARBAM T/2 LAB= 77 DAYS; T/2 OUTDOOR= 13 DAYS. MECARBAM WAS OF INTERMEDIATE PERSISTENCE AMONG THOSE TESTED.

Farm products from the Region of Murcia were tested for the presence of 20 organophosphorus pesticides; the calculated daily ingestion of mecarbam in 1985-1986 was calculated as 2290 ng/person, mainly from citrus fruits(1). Mecarbam was detected at unreported concentrations and sources during a study of 27,065 samples of foods collected in the USA during 1988-1989(2). During the 1989(3) and 1990(4) FDA pesticide residue monitoring program, mecarbam was detected at unreported concentrations.

Dizziness. Nausea. Muscle twitching. Sweating. Pupillary constriction. Muscle cramps. Excessive salivation. Vomiting. Diarrhoea. Laboured breathing. Convulsions. Cough. Blurred vision. Unconsciousness.

See Inhalation.

See Inhalation.

The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to bees. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

Workers handling & applying pesticides must undergo an annual medical examination at the beginning of each agricultural season. Contraindications for work with OPP /organophosphorus pesticides/ are organic diseases of the central nervous system, mental disorders & epilepsy, pronounced endocrine & vegetative disorders, pulmonary tuberculosis, bronchial asthma, chronic respiratory diseases, cardiovascular diseases & circulatory disorders, gastrointestinal diseases (peptic ulcer), gastroenterocolitis, diseases of liver & kidneys, eye diseases (chronic conjunctivitis & keratitis). The blood cholinesterase activity must be determined before work starts. In the event of prolonged work periods, this activity should be determined at intervals of 3-4 days. Persons exhibiting a fall in cholinesterase activity of 25% or more must be transferred to other work where they are not exposed to OPP until this activity is completely restored. Persons with initial signs of indisposition should cease work with pesticides. /Organophosphorus pesticides/

The Koc of mecarbam is estimated as approximately 420(SRC), using an estimated log Kow of 2.29(1,SRC) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that mecarbam has moderate mobility in soil(SRC).

CHOLINESTERASE INHIBITION...

Delayed neurotoxic effects resulting from demyelination in the spinal cord and peripheral motor nerves has been described following exposure to tri-o-cresyl phosphate, leptophos and mecarbam.

All the organophosphorus insecticides have a cumulative effect by progressive inhibition of cholinesterase ... /Organophosphorus insecticides/

The symptoms of chronic poisoning due to organophosphorus pesticides include headache, weakness, feeling of heaviness in head, decline of memory, quick onset of fatigue, disturbed sleep, loss of appetite, & loss of orientation. Psychic disorders, nystagmus, trembling of the hands & other nervous system disorders can be observed in certain cases. Sometimes neuritis, paresis & paralysis develop. /Organophosphorus pesticides/

For more Human Toxicity Excerpts (Complete) data for MECARBAM (8 total), please visit the HSDB record page.

Mecarbam added to a loam soil in a closed system had a half-life of 77 days(1); when added to field sites, an average half-life of 13 days was reported during June-July(1). The rate of degradation slowed considerably during August-September and was very low for October-November(1). Mecarbam residues remaining after 10 months averaged 4%(1). Degradation of this compound may have been due to both biodegradation and hydrolysis(SRC). Mecarbam added to a composite soil had a Ks value of 0.0495, where the Ks value is a constant which measures the rate of dissipation of mecarbam(2).

Used as insecticide and acaricide for rice, tea, fruits, and vegetables; [HSDB]

Farming (Pesticides) [Category: Industry]

INSECTICIDE & ACARICIDE

INCLUDE: 'MURFOTOX' EMULSIFIABLE CONCN (500, 680 & 900 G AI/L); WP (250 G/KG); DUST (15 & 40 G/KG); 'MURFOTOX OIL' (50 G/L) IN PETROLEUM OIL; 'PESTAN' EC (400 G/L).

Technical grade has purity greater than or equal to 85%

The WHO Recommended Classification of Pesticides by Hazard identifies Mecarbam (technical grade) as Class IB: highly hazardous; Main Use: insecticide.

INCOMPATIBILITIES: COMPATIBLE WITH ALL BUT HIGHLY ALKALINE PESTICIDES.

MIN NUMBER OF WK BETWEEN PESTICIDE APPLICATION & TEA HARVEST IN JAPAN IS OFFICIALLY FIXED, BASED ON RESULTS OF ORGANOLEPTIC TESTS ON TREATED & PROCESSED TEA LEAVES. INTERVAL IS 2 WK FOR MECARBAM.

TOXICITY & ANTICHOLINESTERASE ACTIVITY OF 25 ORGANOPHOSPHATE INSECTICIDES WERE COMPARED IN RICE STEM BORERS. STUDY INCL MECARBAM.

For more General Manufacturing Information (Complete) data for MECARBAM (8 total), please visit the HSDB record page.