N-エチル-N-[4-[[4-[エチル[[3-スルホフェニル]メチル]アミノ]フェニル](2-スルホナトフェニル)メチレン]-2,5-シクロヘキサジエン-1-イリデン]-3-スルホベンゼンメタンアミニウムジアンモニウム

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

ALL PUPS WERE ARTIFICIALLY REARED FROM 4 DAYS OF AGE. LIQ DIET CONTAINING FOOD DYES (D) OR NO COLORINGS (N) WAS INFUSED INTO 6-HYDROXYDOPAMINE (6-OHDA) & SHAM-TREATED PUPS. PUPS RECEIVING FOOD DYES WERE SIGNIFICANTLY MORE ACTIVE THAN COMPARABLE PUPS NOT RECEIVING FOOD DYES AT ALL AGES TESTED, AN EFFECT OBSERVED IN 6-OHDA (T) & SHAM-TREATED PUPS (V). PUPS TREATED WITH FOOD DYES EXHIBITED AN IMPAIRED AVOIDANCE PERFORMANCE IN SHUTTLE BOX AT 28 DAYS OF AGE. VD & TN PUPS DISPLAYED MORE THAN A 100% IMPAIRMENT IN AVOIDANCE PERFORMANCE COMPARED WITH VN PUPS. FOOD DYES &/OR THEIR METABOLITES MAY EXERT DELETERIOUS EFFECTS ON THE BEHAVIOR OF DEVELOPING RAT PUPS.

FOOD COLORS INCLUDING BRILLIANT BLUE CAUSED SEVERE GROWTH RETARDATION IN RATS WHEN ADDED TO A BASAL PURIFIED, LOW-FIBER DIET (25% CASEIN-SUCROSE) AT 5% LEVEL.

CARCINOMA OF THE KIDNEY WAS SEEN IN 1 OF 20 SPRAGUE-DAWLEY RATS ADMIN A SINGLE ORAL DOSE OF COLOR INDEX ACID BLUE 9. 1 OF 89 CONTROLS ALSO HAD A CARCINOMA.

... Not damaging in rabbit eye test.

For more Non-Human Toxicity Excerpts (Complete) data for C.I. ACID BLUE 9 (6 total), please visit the HSDB record page.

All batches of this color additive when used as a drug shall meet the specifications, uses and restrictions, and labeling regulations contained in 21 CFR Part 74 and be certified in accordance with regulations in 21 CFR Part 80.

All batches of this color additive when used as a cosmetic shall meet the specifications, uses and restrictions, and labeling regulations contained in 21 CFR Part 74 and be certified in accordance with regulations in 21 CFR Part 80.

A batch of this straight color may be certified, in accordance with 21 CFR Part 82, for use in drugs and cosmetics, if such batch conforms to the requirements of 21 CFR 82.5 and to the specifications in 21 CFR Part 82.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Acid Blue 9 is found on List D. Case No: 4010; Pesticide type: herbicide; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Acid Blue 9; Data Call-in (DCI) Date(s): 09/30/93; AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.