スルホニルジフルオリド

Excerpt from ERG Guide 123 [Gases - Toxic]:

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water.

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer immediately for medical attention .

ON FROSTBITE: rinse with plenty of water. Refer immediately for medical attention. Keep rinsing during transport for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch or walk through spilled material.

Excerpt from NIOSH Pocket Guide for Sulfuryl fluoride:

General First Aid:

(General first aid procedures)

· Wear positive pressure self-contained breathing apparatus (SCBA).

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

If material involved in fire: extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

Store in dry, cool, well ventilated area under lock and key. Post as a pesticide storage area. If the storage area is in an occupied building, the storage area must have either 1) a forced air ventilation system that meets required local ordinances for the storage of hazardous materials and operates continuously; or 2) be equipped with a permanently mounted and properly maintained and functioning sulfuryl fluoride monitoring device designed to alert occupants of the building if sulfuryl fluoride in the air of the storage area is greater than 1 ppm. Store cylinders upright, secured to a rack or wall to prevent tipping. Do not contaminate water, food, or feed by storage. Cylinders should not be subjected to rough handling or mechanical shock such as dropping, bumping, dragging, or sliding. Do not transport any cylinders in closed vehicles where they occupy the same common airspace as personnel. Transport securely only in an upright position. Do not remove valve protection bonnet and safety cap until immediately before use. Replace safety cap and valve protection bonnet when cylinder is not in use. /Vikane/

MAY BE STORED IN COMPRESSED FORM IN STEEL CYLINDERS OR IN GASOMETER OVER SULFURIC ACID.

Store cylinders upright, away from heat in a secured, well ventilated area away from dwellings and work areas. Do not contaminate or store near food, feed, or drugs. When not in use, all full and partially used or empty cylinders must have the valve closed and the valve cover hood securely in place.

Leak Procedures: Evacuate immediate area of leak. Use a NIOSH ... approved positive pressure self-contained breathing apparatus (SCBA, not SCUBA) or combination air-supplied/SCSA respirator ... for entry into affected areas to correct problem. Move leaking or damaged cylinder outdoors or to an isolated location, observing strict safety precautions. Work upwind if possible. Do not permit entry into leakage area by unprotected persons until concentration of fumigant in the breathing zone is determined to be 1 part per miliion (ppm) or less, as determined by a detection device with sufficient sensitivity ... /Vikane/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Cylinder and Product Disposal: Promptly return all empty cylinders to your distributor of Vikane. Follow proper cylinder handling directions above. Pesticide wastes are acutely hazardous, Improper disposal of excess pesticide is a violation of Federal law. If these wastes cannot be disposed of by use according to label instructions, consult your State Pesticide or Environmental Control Agency, or the Hazardous Waste Representative at the nearest EPA Regional Office for guidance. /Vikane/

The following disposal method has been suggested ... allow gas to flow into a mixed solution of caustic soda and slaked lime.

Evacuate danger area! Consult an expert! Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Isolate the area until the gas has dispersed. Shut off cylinder if possible. Remove vapour with fine water spray. Do NOT let this chemical enter the environment.

Therapeutic treatment with calcium gluconate was evaluated ... Rats were exposed to 4000 or 10,000 ppm sulfuryl fluoride for 45 or 16 min (sufficient to result in 100% lethality within 3 hr), respectively, or were treated ip with calcium gluconate prior to and after exposure to sulfuryl fluoride. Animals which were still alive 3 days after exposure ... were considered to have survived. In separate groups of rats, serum fluoride levels were determined in rats exposed to sulfuryl fluoride alone or pretreated with calcium gluconate. Four of five rats pretreated with calcium gluconate prior to exposure to 4000 ppm sulfuryl fluoride survived 3 days after dosing. The other rat died 90 min after exposure. Treatment with calcium gluconate after exposure to sulfuryl fluoride was not effective. While survival was incr in rats pretreated with calcium gluconate, the surviving animals were extremely debilitated with no apparent protection from convulsions. Animals pretreated with calcium gluconate did not survive exposure to 10,000 ppm sulfuryl fluoride. Admin of calcium gluconate resulted in approx 10% incr in serum calcium levels and did not appear to affect serum fluoride or magnesium levels.

Since the cause of death in rats pre- or postexposure treated with calcium gluconate appeared to be due to convulsions, rats were pretreated with 1 of 3 anticonvulsants (phenobarbital, diazepam, or diphenylhydantoin) prior to exposure to 4000 ppm sulfuryl fluoride or were treated postexposure with phenobarbital and diazepam ... Phenobarbital was the most effective anticonvulsant followed by diazepam with 5 of 5 and 4 of 5 pretreated with phenobarbital and diazepam surviving exposure to 4000 ppm for 50 min. Diphenylhydantoin accentuated the adverse effects of sulfuryl fluoride. At higher concn of sulfuryl fluoride, 10,000 ppm, phenobarbital was also ineffective.

The substance can be absorbed into the body by inhalation.

inhalation, skin and/or eye contact (liquid)

/Experimental/ The principal route of fluoride excretion is via the urine. Some excretion takes place through sweat and feces, and fluoride also appears in saliva. Fluoride crosses the placenta; it rarely seems to be excreted in milk to any significant extent. /Fluorides/

/PLANTS/ Orchid plants and a grapefruit tree suffered considerable damage when vikane (SO2F2) was used to fumigate a termite-ridden house 15-30 ft away. Orchids developed black rot and leaf tip rot after 1 wk, and the tree lost its leaves and fruit after 4 days.

/PLANTS/ ... Phytotoxic but with little effect on the germination of weed & crop seeds.

Sore throat. Cough. Shortness of breath. Nausea. Vomiting. Weakness. Heart palpitations. Convulsions. Unconsciousness.

ON CONTACT WITH LIQUID: FROSTBITE.

Redness. ON CONTACT WITH LIQUID: FROSTBITE.

conjunctivitis, rhinitis, pharyngitis, paresthesia; liquid: frostbite: In Animals: narcosis, tremor, convulsions; pulmonary edema; kidney injury

/SIGNS AND SYMPTOMS/ ... Vikane is a gas which has no warning properties such as odor or eye irritation. (However, chloropicrin is used as a warning agent and is a known lachrymator). Early symptoms of exposure to Vikane are respiratory irritation and central nervous system depression. Excitation may follow. Slowed movement, reduced awareness, and slow or garbled speech may be noted. Prolonged exposure can produce lung irritation, pulmonary edema, nausea, and abdominal pain. Repeated exposure to high concentrations can result in significant lung and kidney damage. Single exposures at high concentrations have resulted in death. ... /Vikane/

/SIGNS AND SYMPTOMS/ Poisonings and fatalities have been reported in humans following inhalation exposure to sulfuryl fluoride. The severity of these effects has depended on the concentration of sulfuryl fluoride and the duration of exposure. Short-term inhalation exposure to high concentrations has caused respiratory irritation, pulmonary edema, nausea, abdominal pain, central nervous system depression, and numbness in the extremities. ... Prolonged chronic inhalation exposures to concentrations of sulfuryl fluoride gas significantly above the threshold limit value (TLV) of 5 ppm have caused fluorosis in humans because sulfuryl fluoride is converted to fluoride anion in the body. Fluorosis is characterized by binding of fluoride anion to teeth (causing mottling of the teeth) and to bone. Sulfuryl fluoride and fluoride anion are the residues of concern associated with sulfuryl fluoride. /Fluoride anion/[EPA 40 CFR Part 180

/SIGNS AND SYMPTOMS/ When released from pressurized steel cylinders, sulfuryl fluoride causes freezing of skin and eye tissues on contact.[EPA 40 CFR Part 180

/SIGNS AND SYMPTOMS/ Accidental human exposure caused nausea, vomiting, cramps, itching.

For more Human Toxicity Excerpts (Complete) data for SULFURYL FLUORIDE (16 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ Male rats that inhaled 4000 ppm sulfuryl fluoride survived about 2.5 hours; tonic convulsions were observed just prior to death. With exposure to concentrations up to 40,000 ppm, the time to death decreased in a concentration-dependent manner. Pulmonary edema, cyanosis, respiratory arrest, and convulsions preceded death at the higher concentrations. Because circulating fluoride was elevated in the animals that died, the authors considered that the toxicity of sulfuryl fluoride was due, at least in part, to fluoride.

/LABORATORY ANIMALS: Acute Exposure/ Mice are more sensitive than rats to the acute effects of inhaled sulfuryl fluoride, whereas rabbits were considered somewhat less sensitive; tonic convulsions were recorded after exposure and aveolar hemorrhage/pulmonary congestion was seen in those that inhaled greater than or equal to 6000 ppm.

/LABORATORY ANIMALS: Acute Exposure/ Liq sulfuryl fluoride directly contacting skin can result in frostbite ... Animals exposed to lethal doses of sulfuryl fluoride had tremors and convulsions. The convulsions were characterized by stiffening of the animal to a very rigid position and the toppling over backward. Excessive salivation, loss of bladder control, and chromodacryorrhea were observed also.

/LABORATORY ANIMALS: Acute Exposure/ B6C3F1 mice were exposed to 400, 600, or 1000 ppm for 4 hr ... All animals died within 90 min after termination of the exposure to 1000 ppm and within 6 days following exposure to 600 ppm. Body tremors were observed in several female mice shortly after exposure to 600 ppm and animals surviving after the exposure period were lethargic prior to death. There were no clinically visible effects noted in mice exposed to 400 ppm ...[Krieger, R. (ed.). Handbook of Pesticide Toxicology. Volume 2, 2nd ed. 2001. Academic Press, San Diego, California., p. 1882]

For more Non-Human Toxicity Excerpts (Complete) data for SULFURYL FLUORIDE (52 total), please visit the HSDB record page.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Sulfuryl fluoride is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0176; Pesticide type: antimicrobial; Registration Standard Date: 06/30/85; Case Status: RED Approved 09/93; OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Sulfuryl fluoride; Data Call-in (DCI) Date(s): 07/20/90, 11/10/92, 09/30/93; AI Status: OPP has completed a Reregistration Eligibility Decision (RED) document for the case/AI.

Used as a structural fumigant to kill termites; [ACGIH]

Farming (Pesticides) [Category: Industry]

For sulfuryl fluoride (USEPA/OPP Pesticide Code: 078003) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Insecticide, fumigant

Sulfuryl fluoride is an insecticide used to fumigate closed structures and their contents such as domestic dwellings, garages, barns, storage buildings, commercial warehouses, ships in port, and railroad cars. It controls numerous insect pests including termites, powder post beetles, old house borers, bedbugs, carpet beetles, clothes moths and cockroaches, as well as rats and mice. The end-use product is marketed as a liquid gas in pressurized steel containers.

In January 2004, USEPA registered sulfuryl fluoride (ProFume) as an alternative to methyl bromide for use in structures and mills of cereal grains, dried fruit and tree nuts. In May of 2005, the State of California also registered sulfuryl fluoride for these uses. In July 2005, USEPA expanded the sulfuryl fluoride label by increasing sites to include food processing facilities and more commodities. New York was the last state to register this product in December 2005.

MADE BY THERMAL DECOMP OF BARIUM DI(FLUOROSULFATE) ... .

Prepared by heating barium difluorosulfite; alternate preparation from silver fluoride and sulfur dioxide.

Sulfuryl fluoride may be made by: burning fluorine in sulfur dioxide; heating barium fluorosulfonate.

MASTER FUME Active Ingredient 99.8% Sulfuryl fluoride

DOW AGROSCIENCES/PROFUME GAS FUMIGANT Active Ingredient 99.8% sulfuryl fluoride

VIKANE Active Ingredient 99.8% sulfuryl fluoride

ZYTHOR Active Ingredient 99.3% Sulfuryl fluoride

For more Formulations/Preparations (Complete) data for SULFURYL FLUORIDE (8 total), please visit the HSDB record page.

Sulfuryl fluoride: ACTIVE

Sulfuryl fluoride is dispensed as a pressurized gas from a steel cylinder through a hose into the interior of an enclosed, sealed structure. People must be evacuated from the structure before it is treated; chlorpicrin, which produces a strong odor and eye irritation, is used as a warning agent and is released within the structure 5 to 10 minutes before sulfuryl fluoride is applied to ensure that the site is vacated. After treatment, the structure remains closed for a period of time (refer to the product label for specific times regarding target pest and environmental conditions) after which the applicator reenters and begins to aerate the area. People not wearing a respirator may not reenter the treated structure until air levels of sulfuryl fluoride have declined to 5 part per million (ppm) or less. Because sulfuryl fluoride is a Restricted Use Pesticide, it may only be applied by or under the direct supervision of a trained, certified applicator.

Sulfuryl fluoride has been registered for fumigation of structures for termites under the brand name Vikane for many years. Sulfuryl fluoride is considered to be a methyl bromide replacement for some of these post-harvest fumigation uses. Under the Profume product label, grain processing facilities and stored cereal grains, dried fruits and tree nuts will be fumigated at a maximum use rate of 1,500 ounces/ hours/1,000 ft3 (1,500 milligrams/hours/ liter (mg/hr/L) or 200 mg-hr/L under vacuum conditions. Commodities treated with Profume must be aerated for at least 24 hours before entering commerce.[EPA 40 CFR Part 180

The information available suggests that sulfuryl fluoride structural fumigation costs are comparable to methyl bromide at for the temperatures evaluated (85, 80, and 75 degrees Fahrenheit) when targeting post-embryonic pest life stages. Therefore, use of sulfuryl fluoride appears to be economically feasible in these instances and temperatures. ...Due to increased costs of fumigation, the adoption of sulfuryl fluoride may not be feasible for certain facilities having low profit margins. Sulfuryl fluoride may be a feasible alternative to methyl bromide for post-harvest commodity fumigation in some cases, but in other cases may not be due to efficacy, regulatory, and cost considerations.

UNDER CONDITIONS OF USAGE AS A GRAIN FUMIGANT, SULFURYL FLUORIDE REACTED WITH PROTEIN AND RELEASED INORGANIC FLUORIDE. SOME SULFATE WAS ALSO FOUND.

For more General Manufacturing Information (Complete) data for SULFURYL FLUORIDE (6 total), please visit the HSDB record page.